Abstract Number: PB1126
Meeting: ISTH 2021 Congress
Background: Cancer patients tend to have hypercoagulable state with increased venous thromboembolism (VTE) incidence that raises morbidity and mortality. Previous limited number of studies suggest any inconclusive association among von Willebrand factor (vWF), a disintegrin-like and metalloproteinase with thrombospondin type 1 motif, member 13 (ADAMTS-13), D-dimer, and soluble P-selectin (sP-selectin) with the VTE incidence among cancer patients.
Aims: This study aims to measure the association among vWF, ADAMTS-13, D-dimer, and sP-selectin with VTE incidence in cancer patients.
Methods: We did both comprehensive searching and hand-searching in online databases of Pubmed, EMBASE, ScienceDirect, and The Cochrane Library, to include all relevant literature from 2000 until 2021 then followed the PRISMA guideline. We included all observational studies that access the association among vWF, ADAMTS-13, D-dimer, and sP-selectin with VTE incidence in all cancer patients. Bias risk was accessed by using The Newcastle-Ottawa Scale. Analysis was performed to provide pooled risk ratio (RR) with 95% confidence interval (CI) using random-effect heterogeneity test.
Results: We included 1 case-control and 2 cohort studies fulfilled our inclusion criteria. Increased vWF is significantly associated with VTE incidence among cancer patients (pooled RR = 2.00, 95% CI 1.28-3.13, p=0.002, I2=28%). The ADAMTS-13 (pooled RR = 1.13, 95% CI 0.88-1.44, p=0.35, I2=68%), D-dimer (pooled RR = 1.20, 95% CI 0.78-1.85, p=0.40, I2=71%), and sP-selectin (pooled RR = 1.13, 95% CI 0.64-2.00, p=0.67, I2=21%) are associated with higher VTE risk among cancer patients although not statistically significant.
Conclusions: The von Willebrand factor, ADAMTS-13, D-dimer, and sP-selectin can be potential predictors of VTE incidence among cancer patients. However, further studies are needed to establish the associations.
To cite this abstract in AMA style:Putra BP, Putra FN. The Association among von Willebrand Factor, ADAMTS-13, D-dimer, and Soluble P-selectin with Venous Thromboembolism Incidence in Cancer Patients: Systematic Review and Meta-analysis [abstract]. Res Pract Thromb Haemost. 2021; 5 (Suppl 2). https://abstracts.isth.org/abstract/the-association-among-von-willebrand-factor-adamts-13-d-dimer-and-soluble-p-selectin-with-venous-thromboembolism-incidence-in-cancer-patients-systematic-review-and-meta-analysis/. Accessed November 29, 2023.
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