Abstract Number: PB0240
Meeting: ISTH 2021 Congress
Theme: COVID and Coagulation » COVID and Coagulation, Clinical
Background: Coagulation disturbances in COVID-19 pneumonia patients is already a well-known fact, but what marker can really reflect the disease progression is still unknown.
Aims: The aim was to estimate the diagnostic and prognostic role of different coagulation markers in hospitalized patients with confirmed COVID-19 pneumonia.
Methods: The main group was 53 patients (age – 59 (52; 65), men – 22 (41,5 %)) with COVID-19 pneumonia, divided into 3 subgroups: subgroup 1 – 36 patients with moderate COVID-19 pneumonia, subgroup 2 – 12 patients with severe COVID-19 pneumonia, subgroup 3 – 5 patients with critical COVID-19 pneumonia. General clinical analysis, blood coagulation test, determination of D-dimer and fibrinogen was performed at admission before starting of antibacterial and anticoagulant treatment.
Results:
| Parameter | subgroups | references | р | ||
| 1 (n=36) |
2 (n=12) |
3 (n=5) |
|||
| INR | 1,06 (0,95; 1,2) |
1,05 (1,0; 1,1) |
1,1 (1,01; 1,2) |
0,8–1,2 | р1-2=0,910 р1-3=0,480 р2-3=0,386 |
| prothrombin, % | 94,1 (80,9; 104,6) |
94,5 (76,2; 103,1) |
81,4 (72,0; 90,0) |
80–120 | р1-2=0,900 р1-3=0,197 р2-3=0,102 |
| prothrombine time, s | 13,5 (12,2; 14,5) |
13,6 (12,1; 14,1) |
15,2 (93,0; |
11–15 | р1-2=0,830 р1-3=0,183 р2-3=0,342 |
| Fibrinogen, g/l | 3,7 (3,0; 4,7) |
4,2 (3,7; 4,9) |
7,0 (6,5; 7,5) |
2–4 | р1-2=0,044 р1-3=0,033 р2-3=0,015 |
| D-dimer, ng/ml | 679,9 (118,1; 170,0) |
1103,1 (188,9; 1803,5) |
5720 (4800; 7500) |
0–285 | р1-2=0,149 р1-3=0,000 р2-3=0,009 |
Levels of coagulation parameters in hospitalized patients with COVID-19 pneumonia
Individual analysis showed that 28 patients from group 2 and 3 had progression of COVID-19 pneumonia in dynamic, which was manifested with increased respiratory failure and connected with lung vessel thrombosis.
The ROC-analysis showed that only the level of D-dimer at admission can really reflects the severity of COVID-19 pneumonia and predicts the prognosis of the disease.
ROC-curve of D-dimer
Conclusions: 1) common coagulation parameters neither reflect severity no predict thrombosis in hospitalized patients with COVID-19;
2) Increasing of D-dimer on level 200 ng/ml at admission not only reflects the severe or critical course of in hospitalized patients with COVID-19, but also associated with lung vessel thrombosis and predicts the progression of disease.
To cite this abstract in AMA style:
Krykhtina M, Bielosludtseva K, Pertseva T, Konopkina L. The Comparison of Different Coagulation Markers in Thrombosis Prediction in COVID-19 Pneumonia [abstract]. Res Pract Thromb Haemost. 2021; 5 (Suppl 2). https://abstracts.isth.org/abstract/the-comparison-of-different-coagulation-markers-in-thrombosis-prediction-in-covid-19-pneumonia/. Accessed December 6, 2023.« Back to ISTH 2021 Congress
ISTH Congress Abstracts - https://abstracts.isth.org/abstract/the-comparison-of-different-coagulation-markers-in-thrombosis-prediction-in-covid-19-pneumonia/