Abstract Number: PO149
Meeting: ISTH 2021 Congress
Background: Hemophilia C or Rosenthal syndrome caused by the factor of XI (FXI) deficiency and known as plasma thromboplastin antecedent deficiency belongs to a mild form of hemophilia. Hemophilia C is considered a rare disease requiring further investigations.
Aims: To describe a clinical case of acquired hemophilia C in a patient in Armenia who previously underwent two surgeries without bleeding complications and coagulopathy.
Methods: A retrospective review of the patient’s medical history was performed.
Results: A 66-year-old male presented with frequent urination complaints with decreased urine output, dysuria, and sometimes a feeling of incomplete bladder emptying. The prostate incision for sclerosis, TUR biopsy of the prostate and bladder were performed. Bleeding from the urethra observable on the first day after surgery was stopped with conservative measures. On the sixth day after the surgery, the patient had more severe and intense bleeding from the urethra. The problem was solved by suprapubic cystostomy. The blood tests showed high-normal activated plasma thromboplastin time-88.9s (normal range: 26-40s), prothrombin time-13.5s (normal range: 11.9 – 15.4s), and internationalized normal ratio-1.2. Factors VIII, IX, and XIII levels were within the normal range-98%, 102%, and 82%, respectively. Whereas the FXI level reduced to 3.9% (normal range: 60-150%), thereby helping to diagnose intermediate FXI deficiency. Transitory antibodies against FXI were developed. Though the patient didn’t receive anti-hemophilia therapy and had FXI deficiency, he had no bleeding disorders during last five years.
Conclusions: The deficiency of FXI can develop at any age, and the cause of it can only be revealed on the basis of reliable data on the detection of genetic mutations. The temporary appearance of antibodies and their current absence did not allow confirming the immune nature of hemophilia.
To cite this abstract in AMA style:Melnichenko I, Arakelyan T, Sargsyan N, Sargsyan L, Danielyan S, Tamamyan G, Khachatryan H. The Detection of Hemophilia C in a 66-year-Old Patient with Postoperative Urinary Bleeding [abstract]. Res Pract Thromb Haemost. 2021; 5 (Suppl 2). https://abstracts.isth.org/abstract/the-detection-of-hemophilia-c-in-a-66-year-old-patient-with-postoperative-urinary-bleeding/. Accessed December 11, 2023.
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