Background: There are limited data about lung vessel thrombosis in patients with community-acquired pneumonia (CAP). Moreover, there are no enough data about prognostic factors of this event.

Aims: To evaluate the diagnostic value of serum levels of protein C (PC) and Padui score as predictors of lung vessel thrombosis in patients with CAP.

Methods: This was a prospective observational study in 75 adults (80% men) with moderate (n=41) to severe (n=34) CAP. determination of biomarkers PC were performed at admission before starting of antibacterial treatment. Calculation scores by Padui scale. Statistic included ROC-analysis.

Results: We allocated 12 patients with lung vessel thrombosis (in 7 patients – on chest CT and in 5 patients – on autopsy).

[The result of ROC-analysis]

Conclusions: Serum level of PC is independent and the more specific (89.3%) and sensitive (66.7%) biomarker for estimation of lung thrombosis in hospitalized patients with CAP. As for Padui scale specific is 83.3% and sensitive – 57.1%. Therefore, serum PC and Padui scale could be used for prediction of lung vessel thrombosis in patients with community-acquired pneumonia.

[ROC analysis]

« Back to ISTH 2020 Congress

ISTH Congress Abstracts - https://abstracts.isth.org/abstract/the-diagnostic-and-prognostic-role-of-protein-c-and-padui-scale-for-prediction-of-lung-vessel-thrombosis-in-patients-with-community-acquired-pneumonia/