Abstract Number: PB0780
Meeting: ISTH 2021 Congress
Background: Anti-platelet membrane glycoprotein antibody is the main cause of platelet destruction, and IVIG combined with glucocorticoids is the standard regimen.
Aims: To study the distribution of anti-GP subtypes in children with primary immune thrombocytopenia, and to evaluate the the relationship between anti-GP subtypes and the therapeutic effect.
Methods: A retrospective analysis of 320 children with ITP from September 2013 to April 2019 was determined. They were divided into newly diagnosed ITP group (127 cases), persistent ITP group (101 cases) and chronic ITP group (92 cases). Monoclonal antibody-specific platelet antigen fixation (MAIPA) was used to detect anti-GP IIb/IIIa and anti-GP Ia/IIa in each group, and the relationship between the distribution of anti-GP subtypes and the therapeutic effect was analyzed.
Results: The positive rates of platelet membrane glycoprotein antibody in the newly diagnosed ITP group, persistent ITP group, and chronic ITP group were 40.9%, 22.8%, and 26.1%, respectively, the difference was statistically significant (P=0.006).The positive rate of anti-GP IIb/IIIa, and anti both GP IIb/IIIa and GP Ia/ IIIa were 19.7% and 10.2% in the newly diagnosed ITP group, which showed no statistical significance compared with the persistent group (14.9%, 3%) and chronic group (10.9%, 5.4%) (P values were 0.201 and 0.078, respectively).The effective rate of IVIG combined with glucocorticoids in anti-GP IIb/IIIa positive children (94.6%) and antibody negative patients (96.3%) showed no statistically significant difference (P=0.458).The effective rate of IVIG combined with glucocorticoids in anti-GP IIb/IIIa and GP Ia/ IIIa both positive patients (78.6%) was lower than negative patients (97.3%), and the difference was statistically significant (P=0.003).
Conclusions: The positive rate of anti-GP IIb/IIIa, and anti-GP IIb/IIIa and GP Ia/ IIIa were higher in newly diagnosed pediatric ITP, but wit no statistical significance. Patients with anti-GP IIb/IIIa and GP Ia/IIa both negative responded well to the standard regimen of IVIG combined with glucocorticoids.
To cite this abstract in AMA style:Li R, Yang R. The Distribution of Anti-platelet Membrane Glycoprotein Antibodies Subtypes in Children with Primary Immune Thrombocytopenia and its Relationship with Therapeutic Effect [abstract]. Res Pract Thromb Haemost. 2021; 5 (Suppl 2). https://abstracts.isth.org/abstract/the-distribution-of-anti-platelet-membrane-glycoprotein-antibodies-subtypes-in-children-with-primary-immune-thrombocytopenia-and-its-relationship-with-therapeutic-effect/. Accessed August 16, 2022.
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