ISTH Congress Abstracts

Official abstracts site for the ISTH Congress

MENU 

The Effect of Aspirin in Tumor Growth of Obese Mice Involving Inhibition of Metabolism

1Taichung Veterans General Hospital, Rare Disease and Hemophilia, Taichung, Taiwan, Republic of China, 2Taichung Veterans General Hospital, Department of Medical Research, Taichung, Taiwan, Republic of China, 3National Chung Hsing University, Veterinary Medicine, Taichung, Taiwan, Republic of China, 4Taichung Veterans General Hospital, Taichung, Taiwan, Republic of China, 5National Yang Ming University, Taipei, Taiwan, Republic of China

Abstract Number: PB1389

Meeting: ISTH 2020 Congress

Theme: Platelet Disorders and von Willebrand Disease » Antiplatelet Therapy

Background: Aspirin is a widely used antiplatelet drug. Beyond its cardiovascular and cerebrovascular effects, epidemiological, clinical, and experimental evidence has shown that aspirin plays certain roles with regards to anticancer.

Aims: This study was conducted to identify any metabolic alterations in obese mice and to also investigate the anticancer effects of aspirin on obesity-driven cancer malignancy, by taking advantage of the syngeneic tumor model.

Methods: Using a syngeneic tumor model involving Lewis Lung Carcinoma (LLC) cells and C57BL/6 mice fed with a high fat diet, obesity was found to be associated with dysregulated glucose and glutamine metabolism, inflammation, along with platelet activation and the promotion of tumor growth.

Results: Tumor-bearing lowered glucose levels while moderately increasing inflammation, platelet activation, and glutamine levels. The antiplatelet drug aspirin, mitigated tumor growth in obese mice, paralleled by a decrease in systemic glucose, insulin, inflammation, platelet activation, glutamine and tumor expression of cell proliferation, aerobic glycolysis, glutaminolysis, platelets, and leukocyte molecules.

Conclusions: The anticancer effects of the antiplatelet drug aspirin are multifactorial. Glucose and glutamine metabolism are proposed targets for the anticancer effects of aspirin.

To cite this abstract in AMA style:

Wang J-, Chen C-, Chen W-, Li J-, Lin S-, Wang Y-. The Effect of Aspirin in Tumor Growth of Obese Mice Involving Inhibition of Metabolism [abstract]. Res Pract Thromb Haemost. 2020; 4 (Suppl 1). https://abstracts.isth.org/abstract/the-effect-of-aspirin-in-tumor-growth-of-obese-mice-involving-inhibition-of-metabolism/. Accessed January 21, 2022.

« Back to ISTH 2020 Congress

ISTH Congress Abstracts - https://abstracts.isth.org/abstract/the-effect-of-aspirin-in-tumor-growth-of-obese-mice-involving-inhibition-of-metabolism/