Abstract Number: PB2476
Meeting: ISTH 2020 Congress
Theme: Venous Thromboembolism and Cardioembolism » VTE Treatment
Background: In the process of aging, the body undergoes involutive changes that determine the peculiarities of analgesic methods in gerontological patients.
Aims: Goal. To study the effect of postoperative analgesia in gerontological patients with polytrauma on the state of the hemostatic system.
Methods: Materials and methods. A total of 94 patients over 70 years old with polytrauma after surgical correction were examined. Patients were divided into three groups: in the 1st group (n = 31), postoperative analgesia was performed with morphine, in the 2nd (n = 31) – nalbuphine, in the 3rd (n = 32) – with a combination of infulgan (COX inhibitor – 2) and rheumoxicam (COX-3 inhibitor). The hemostatic system parameters were studied: antithrombin-III (AT-III) and soluble fibrin-monomer complex (RFMC).
Results: On the 1st day after surgery in groups 1 and 2 there was a tendency to hypercoagulation: an increase in the level of RFMC and a decrease in the activity of AT III. In the 3rd group, the RFMC and AT III indicators did not change on the 1st day and amounted to 42.6 mg / L and 69.7% and began to differ from the 1st group. Until 3 days, these indicators did not change in group 1 and 2: the RFMC level decreased by 1.2% and 3.5% compared to the previous stage, while AT III increased by 3.8% and 3.2 % compared with the previous stage 1 and 2, and in group 3, the concentration of RFMC continued to decrease by 11.1%, the activity of AT III – increased by 11.4% compared with the previous stage.
Conclusions: Conclusions. The use of a combination of COX-2 and COX-3 inhibitors for postoperative analgesia in gerontological patients with polytrauma has a positive effect on the hemostatic system: the concentration of RFMC is significantly reduced and the concentration of AT-III is significantly increased.
To cite this abstract in AMA style:
Volkova Y, Mikhnevich K, Dolzhenko M. The Effect of Postoperative Analgesia on the Hemostatic System in Gerontological Patients with Multiple Trauma [abstract]. Res Pract Thromb Haemost. 2020; 4 (Suppl 1). https://abstracts.isth.org/abstract/the-effect-of-postoperative-analgesia-on-the-hemostatic-system-in-gerontological-patients-with-multiple-trauma/. Accessed April 18, 2024.« Back to ISTH 2020 Congress
ISTH Congress Abstracts - https://abstracts.isth.org/abstract/the-effect-of-postoperative-analgesia-on-the-hemostatic-system-in-gerontological-patients-with-multiple-trauma/