Abstract Number: PB0380
Meeting: ISTH 2020 Congress
Theme: Coagulation and Natural Anticoagulants » Protein C Pathway
Background: Protein C is a major coagulation inhibitor. Its active form binds and deactivates coagulation factors, thereby regulating the formation of a blood clot, slowing it down. In the bloodstream, it is inactive, activated on the surface of platelets and endothelial cells under the influence of thrombomodulin and thrombin.
Aims: Evaluation of the role of protein C in various links of hemostasis in the pathogenesis of thrombophilia in chronic leukemia and in hypocoagulation states.
Methods: The study included 120 patients. Of these, 30 patients with multiple myeloma (MM) and 30 with aplastic anemia (AA), 30 patients with chronic myelogenous leukemia (CML) and 30 with idiopathic thrombocytopenic purpura (ITP). The control group consisted of 20 healthy donors of comparable age without pathology of the hemostatic system.
Results: Diagnosis of disorders in the hemostatic system is extremely important, as it will allow you to prescribe antithrombotic therapy on time or to carry out the correction of an ongoing anticoagulation treatment. Thus, the most informative method of laboratory screening diagnosis of a prethrombotic condition has been established: a generally evaluating test of the protein C system.
Table 1
Protein C indices in patients with hemostasis pathology.
| Protein C (70-140%) | P | |
| multiple myeloma (n=30) | 68±6,6 | ≤ 0,5 |
| CML (n=30) | 66±8,3 | ≤ 0,5 |
| АА(n=30) | 160±8,1 | ≤ 0,05 |
| ITP (n=30) | 157±1,1 | ≤ 0,05 |
| control group (n=20) | 108±4,6 |
[Protein C indices in patients with hemostasis pathology]
The table below shows that the pro-inflammatory proteins we are studying clearly indicate the presence of multidirectional disorders. Marked changes in the hemostatic system in the study of chronic leukemia were characterized by hypercoagulation, thrombinemia, vascular-platelet disorders, which were exacerbated by a decrease in the activity of protein C.
Conclusions: In the studied groups with chronic leukemia, there is a decrease in the activity of protein C, but in the groups with hypocoagulation this indicator was equal to normal, which means that the bleeding syndrome in these patients is not associated with the activity in the blood of Protein C, but is associated with other disorders in the coagulation unit hemostasis.
To cite this abstract in AMA style:
Makhmudova A, Berger I, Ashurova L, Juraeva N. The Effect of Protein C on Various Links of Hemostasis [abstract]. Res Pract Thromb Haemost. 2020; 4 (Suppl 1). https://abstracts.isth.org/abstract/the-effect-of-protein-c-on-various-links-of-hemostasis/. Accessed September 21, 2023.« Back to ISTH 2020 Congress
ISTH Congress Abstracts - https://abstracts.isth.org/abstract/the-effect-of-protein-c-on-various-links-of-hemostasis/