Abstract Number: PB0109
Meeting: ISTH 2020 Congress
Background: The crucial role in the development of atherotrombosis in arterial hypertension (AH) played thrombocyte activation. Different studies have shown controversial results in blood platelet functionality profiles due to the influence of diabetes mellitus of type 2 (DM 2) on the background of AH.
Aims: To set the types and relationship of the thrombocyte activation inducted by epinephrine in the clinical course of AH with DM 2.
Methods: We have learned 252 patients, aged 34 to 67 years: among them 124 people were with AH of high risk and 128 people were with AH with very high risk (+ DM type 2). The 3 indexes of epinephrine-induced platelet aggregation (the level, time and rate of aggregation) and the plasma levels of triglycerides (TG), total cholesterol (TC), LDL-cholesterol (LDL-C), HDL-cholesterol (HDL-C), glucose and insulin were measured.
Results: We have set significant increase of the level and rate of aggregation (p< 0,05) in the group of AH with the high risk. There was significant difference between the time of aggregation in all groups (p>0,05). We have set a reliable positive correlation between the level of aggregation and TC (R=0,22; р=0,01) and rate of aggregation and TC (R=0,26; р=0,002). We have found the weak relation between the increase of LDL-C and the level of aggregation (R=0,21; р=0,028) and TG and the level of aggregation (R=0,22; р=0,05). But there weren’t significant interrelations between the aggregation and the levels of glucose and insulin. The independent (in-group) correlation coefficients for glucose and insulin were also unreliable (p>0,05).
Conclusions: The AH with DM type 2 followed by the activation of thrombocytes, which didn’t directly deal with glucose and insulin level, but depended on changes of lipidic profile.
To cite this abstract in AMA style:Shorikov E, Shorikova D, Shorikov P, Khukhlina O. The Epinephrine-induced Platelet Aggregation Changes in Arterial Hypertension of Very High Risk [abstract]. Res Pract Thromb Haemost. 2020; 4 (Suppl 1). https://abstracts.isth.org/abstract/the-epinephrine-induced-platelet-aggregation-changes-in-arterial-hypertension-of-very-high-risk/. Accessed October 2, 2023.
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