Abstract Number: PB1145
Meeting: ISTH 2021 Congress
Theme: Venous Thromboembolism » Genetic Risk Factors of Thrombosis
Background: Intracranial thrombosis (ICT) is rare in children. Early diagnosis is important for the outcome.
Aims: The aim of this study was to evaluate the etiology, clinical findings and imaging, and prognosis in children with ICT.
Methods: We, retrospectively analyzed the ICT diagnosed within the last 10 years excluding neonates and children with malignancy.
Results: A total of 54 patients (M / F: 27/27) were included. The median age was 62.2 (2-193)months. The mean follow-up period was 53 (0-186) months. The majority of cases had arterial thrombosis (59%) whereas venous thrombosis was detected in 41% of children. The most frequently involved artery and veins were arteria cerebri media (33%) and transverse sinus (28%). Family history was found positive in 15% of the patients. Mutation analysis and Protein C, S levels were available 87% and 70% of cases, respectively. Homozygous MTHFR (32%), FVL (19%) homozygous PAI (4%) and prothrombin mutations (4%) were detected. Protein S and C deficiencies were found in 13% (n: 5/38) and 3% (n=1/38) of cases, respectively. The most common acquired risk factors were infection (28%), surgery (9%) and trauma (7%). No acquired risk factors were identified in 22 (41%) children. Seizures (28%), vomiting (22%), fever (19%) and headache (19%) were the most common symptoms. Hemiplegia/hemiparesis (35%), papillary edema (11%), and facial paralysis (5.5%) were frequent. LMWH and ASA were used for treatment. Prophylaxis was applied to 70% of children. None of the children died of thrombosis. Although 59% of the children recovered, chronic sequelae occurred in 43%. The thrombosis recurred only in one child.
Conclusions: It is important to reach an accurate and rapid diagnosis of ICT. Majority of the patients had a genetic risk factor (94%; n=44/54). Therefore, we strongly suggest that all children with ICT should be searched for thrombophilic mutations. Children should be closely followed for chronic sequelaes.
To cite this abstract in AMA style:
Meral Güneş A, Güler S, Tüfekçi Ö, Sezgin Evim M, Baytan B, Yılmaz Ş, Ören H. The Evaluation of the Children with Intracranial Thrombosis [abstract]. Res Pract Thromb Haemost. 2021; 5 (Suppl 2). https://abstracts.isth.org/abstract/the-evaluation-of-the-children-with-intracranial-thrombosis/. Accessed March 22, 2024.« Back to ISTH 2021 Congress
ISTH Congress Abstracts - https://abstracts.isth.org/abstract/the-evaluation-of-the-children-with-intracranial-thrombosis/