Abstract Number: PB0602
Meeting: ISTH 2022 Congress
Background: Haemophilia is a genetic bleeding disorder caused by the deficiency of clotting factor-VIII or factor-IX. The challenge to have access to factor VIII and IX concentrate could have been compounded by the COVID-19 pandemic and affected the health and lifestyle of haemophilia patients in an already low resourced lower-middle-income country like Ghana.
Aims: This study was aimed at determining the effect of COVID-19 on prolonged Activated Partial Thromboplastin Time (aPTT) among haemophilia ‘A’ patients in the middle belt of Ghana.
Methods: We retrospectively evaluated, for 12 months before the COVID -19 pandemic and followed up on 45 haemophilia patients during the pandemic for this study. Questionnaires were administered to the study participants. Blood samples were collected before the COVID-19 pandemic. Further samples were collected in the pandemic period into citrate tubes and tested for aPTT. SPSS v21 was used for the analysis of the data and P-value < 0.05 was considered statistically significant.
Results: We found that aPTT test result of study participants increased significantly from the pre-pandemic to the pandemic period (68.04±15.97s to 160.80±87.90s, p < 0.001) Also, there was a statistically significant increase between aPTT results of participants that could not visit the clinic during the pandemic to participants who visited (194.6±86.5s to 128.4±77.9s, p = 0.009). Finally, the comparison of aPTT of participants who were impacted by COVID-19 restrictions to that of those who did not suffer restrictions was statistically different (168.3±87.6s to 124.3±81.2s, p = 0.042), with those who suffered restrictions having prolonged aPTT results.
Conclusion(s): We observed a very high increase in the aPTT of in the pandemic period compared to the pre-pandemic period. Patients who suffered government restrictions and could not travel to assess health centres and patients who could not visit the hospital during the pandemic had a prolonged aPTT making them susceptible to prolonged bleeding episodes.
To cite this abstract in AMA style:OFOSU D, Obirikorang C, Ngala R, Asamoah A, Tuekpe Mawuli R, Owusu E, Quarshie S, Owusu Banahene A, Titus M, Asare Amponsah G. THE IMPACT OF COVID-19 PANDEMIC ON THE HEALTH AND LIFESTYLE HEMOPHILIA PATIENTS IN A LOW RESOURCED COUNTRY AND ITS EFFECT ON THEIR ACTIVATED PARTIAL THROMBOPLASTIN TIME (aPTT) RESULTS [abstract]. https://abstracts.isth.org/abstract/the-impact-of-covid-19-pandemic-on-the-health-and-lifestyle-hemophilia-patients-in-a-low-resourced-country-and-its-effect-on-their-activated-partial-thromboplastin-time-aptt-results/. Accessed October 2, 2023.
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