Abstract Number: PB1008
Meeting: ISTH 2022 Congress
Theme: Coagulation and Natural Anticoagulants » Critical Care and Perioperative
Background: Robot-assisted radical prostatectomy (RARP) represents the first-choice surgical procedure for the treatment of localized prostate cancer. The effects of blood parameters and blood groups on the bleeding risk had never been investigated.
Aims: To investigate whether blood parameters and/or blood groups may influence the bleeding risk in patients undergoing RARP.
Methods: We conducted a prospective cohort study enrolling consecutive patients undergoing RARP in our hospital, from January 2017 to December 2020. Patients were evaluated with full blood count and blood groups characterization before and after surgery. Demographic and clinical data were collected with particular attention to other known risk-factors for RARP-associated bleeding (prostate volume, BMI, smoking status, nerve sparing technique).
Bleeding was assessed both as direct quantification of blood loss during surgery and the difference in hemoglobin values pre- and post-surgery.
Linear regression analyses were performed, corrected for confounders and known risk factors for RARP-associated bleeding, and risk estimates were evaluated following Woolf’s method.
Results: In the study period 191 consecutive patients were enrolled; mean age was 67.8 years. Mean blood loss was 366.2 mL [Table 1].
When analyzing the basal hematocrit with linear regression, a strong negative correlation was seen with the difference in hemoglobin pre- and post-surgery (p < 0.001). The relationship remained strong after correction for age, smoke, BMI, prostate volume and nerve sparing (p < 0.001). Pre-surgery hemoglobin levels were less associated with an increased bleeding risk (p=0.07), while PT, aPTT and platelet count did not influence surgical losses. Individuals carrying the blood group O were not at increased risk for higher blood loss (OR = 0.76; 95%CI 0.4-1.4; p=0.4).
Conclusion(s): A lower basal hematocrit is associated with an increased bleeding during RARP.
Lower basal platelet count and O blood group were not associated with greater bleeding.
To cite this abstract in AMA style:
Arcudi S, Artoni A, De Lorenzis E, Silvani C, Spanu F, Villa S, Capecchi M, Montanari E, Peyvandi F. The impact of hematocrit on postoperative bleeding risk in patients undergoing robotic radical prostatectomy [abstract]. https://abstracts.isth.org/abstract/the-impact-of-hematocrit-on-postoperative-bleeding-risk-in-patients-undergoing-robotic-radical-prostatectomy/. Accessed March 21, 2024.« Back to ISTH 2022 Congress
ISTH Congress Abstracts - https://abstracts.isth.org/abstract/the-impact-of-hematocrit-on-postoperative-bleeding-risk-in-patients-undergoing-robotic-radical-prostatectomy/