Abstract Number: PB1010
Meeting: ISTH 2020 Congress
Theme: Hemophilia and Rare Bleeding Disorders » Hemophilia - Clinical
Background: Nowadays, prophylaxis is the gold-standard of treatment of patients with haemophilia, minimizing the consequences of joint bleeds and improving quality of life. Pharmacokinetics (a branch of pharmacology that studies distribution of a drug in the body) allows individualizing and optimizing the treatment of individual patients, so it is guaranteed a good hemostatic coverage and hemophiliacs should be encouraged to practice sports.
Aims: In a monocentric observational cross-over study, we studied the pharmacokinetics of FVIII / IX during physical activity. The aim of the study is to evaluate the changes in the pharmacokinetic curves during physical activity and compare the individual pharmacokinetic data with a population pharmacokinetic algorithm.
Methods: For each patient we evaluated the pharmacokinetic curves during mild activity (< 10000 steps / day) and moderate / intense (>10000 steps / day). Physical activity it has been monitored by a step counter. We evaluated the influence of physical activity on the standard pharmacokinetic curves and compared with individual pharmacokinetics (according to AICE guidelines) with a population pharmacokinetic algorithm (e.g. WAPPS).
Results: A total of 20 patients affected by hemophilia were enrolled. 15 patients (75%) were affected by hemophilia A while 5 patients (25%) where affected by hemophilia B. The pharmacokinetic curves performed during mild physical activity appeared significantly better in all times evaluated than those performed during moderate / intense activity.
Conclusions: The study of pharmacokinetic curves correlated to the physical activity allows to personalize the treatment and modulate therapy by increasing it in those who perform more physical activity and reducing it in those who perform less. The individualized therapy guarantees greater safety during sport but also savings when there is less movement.
Signed informed consent has been acquired from the patient’s parents.
The study was approved by a recognized medical ethics committee.
To cite this abstract in AMA style:
Pastore C, Lassandro G, Amoruso A, Palmieri VV, Palladino V, Giordano P. The Impact of Physical Activity on the Pharmacokinetics of Factor VIII / IX in a Cohort of Pediatric Patients with Hemophilia A / B in Pharmacological Prophylaxis [abstract]. Res Pract Thromb Haemost. 2020; 4 (Suppl 1). https://abstracts.isth.org/abstract/the-impact-of-physical-activity-on-the-pharmacokinetics-of-factor-viii-ix-in-a-cohort-of-pediatric-patients-with-hemophilia-a-b-in-pharmacological-prophylaxis/. Accessed March 21, 2024.« Back to ISTH 2020 Congress
ISTH Congress Abstracts - https://abstracts.isth.org/abstract/the-impact-of-physical-activity-on-the-pharmacokinetics-of-factor-viii-ix-in-a-cohort-of-pediatric-patients-with-hemophilia-a-b-in-pharmacological-prophylaxis/