Background: Thrombotic complications are a serious event in patients with diffuse large B cell lymphoma (DLBCL). The incidence and risk factors for developing arterial thromboembolism (ATE) events is still unclear and therefore needs to be studied further.

Aims: To identify the incidence and risk factors of venous thromboembolism (VTE) and arterial thromboembolism (ATE) events in DLBCL patients.

Methods: This observational study was conducted as a retrospective and prospective cohort study from January 2010 to December 2021 in Trang Hospital.

Results: 189 patients newly diagnosed with DLBCL were included in this study. The average age was 62.07±15.99years and the average body mass index (BMI) was 22.61±4.63kg/m2. Baseline characteristics were 53.4% males, 24.3% BMI ≥25kg/m2, 41.8% performance status >1, 51.9% stage >2, 63.5% lactate dehydrogenase >247U/L, 26.5% hemoglobin < 10g/dL, 14.3% white blood cell ≥11,000/µL, 9.5% platelet count ≥450,000/µL and 15.3% mass size ≥7.5cm. The most common underlying illnesses in DLBCL patients were hypertension (12.8%), hyperlipidemia (11.1%), diabetes mellitus (10.6%) and other underlying illnesses were atrial fibrillation (1.1%), sequelae of CVA (4.8%), Old myocardial infarction (1.1%) and no previous VTE. The incidence of VTE was 1.6% deep vein thrombosis (DVT) and 1.1% pulmonary embolism (PE). The incidence of ATE was 1.1% myocardial infarction and 0.5% ischemic stroke. Only mass size ≥7.5cm. was significantly associated with PE in DLBCL patients (P-value 0.0258). Risk factor of ATE events in DLBCL patients found only BMI ≥25kg/m2 was nearly significantly associated with ischemic stroke (P-value 0.058).

Conclusion(s): The incidence of PE in DLBCL patients was similar compared to Western country studies but low incidence of ATE events. DLBCL patients with bulky disease seem to increase the risk for developing PE. A large prospective cohort study with longer duration follow-up is required for further confirmation.

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ISTH Congress Abstracts - https://abstracts.isth.org/abstract/the-incidence-and-risk-factors-of-thrombotic-complications-in-patients-with-diffuse-large-b-cell-lymphoma-at-trang-hospital/