Abstract Number: PB1292
Meeting: ISTH 2021 Congress
Background: Antithrombin III (AT III) provides at least 75-80% of the anticoagulant activity of plasma. AT III deficiency is the serious risk factor of the progression of venous and, much less frequently, arterial thrombosis. Combined oral contraceptives (COC) is one of the most effective and commonly used methods of preventing unwanted pregnancies in the world.
Aims: To study the influence of thrombophilic history and thrombotic complications heredity on the AT III level in COC recipients.
Methods: A cross-clinical laboratory study was carried out among 100 women at the average age of 29.0 (23.3-35.0) years. Depending on the COC reception mode, women were divided into two groups (n = 50 in each group). The progressive activity of AT III was discovered and a questionnaire was conducted to determine the presence of a thrombophilic history and thrombotic complications heredity. The method of linear regression was used to identify independent factors, having impact on the level of AT III.
Results: Both analyzes, onefactor and multifactor, showed a statistically significant effect of aggravated anamnesis and thrombotic complications heredity (p = 0.022 and p = 0.027, respectively) on the decrease in AT III activity. The results indicate the importance of collecting a thrombophilic history before prescribing COCs.
According to the results of this study taking COC does not have a significant effect on the level of AT III.
Conclusions: This conclusion can be explained, firstly, by the fact that almost all women participating in the study were prescribed COCs by a gynecologist, and secondly, all participants in our study used COCs with a maximum dose of EE of 30 μg.
To cite this abstract in AMA style:Vorobyeva N, Gamyrkina D. The Influence of Thrombophilic Anamnesis and Thrombotic Complications Heredity [abstract]. Res Pract Thromb Haemost. 2021; 5 (Suppl 2). https://abstracts.isth.org/abstract/the-influence-of-thrombophilic-anamnesis-and-thrombotic-complications-heredity/. Accessed November 29, 2021.
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