Background: The International Society of Thrombosis and Haemostasis (ISTH) disseminated intravascular coagulation (DIC) score is widely used to predict survival in critically ill – typically septic – patients.

Aims: To investigate whether the ISTH DIC score can be used to predict the 30-day mortality in non-septic patients in an intensive care unit (ICU).

Methods: In this single-center, prospective, observational study we included all patients ≥18 years of age who were admitted to a medical ICU with a focus on cardiovascular diseases between August 2012 and 2013. The DIC score was calculated at admission (DIC-0h) and 72 hours thereafter
(DIC-72h) and classified as overt when ≥ 5.

Results: A total of 233 patients were included in this study (61% male; median age 65.9 years). Overt DIC-0h and overt DIC-72h were associated with a significantly higher 30-day mortality rate at admission (53.8% vs. 22.2% and 50.0% vs. 18.1%; respectively; p < 0.001). A sensitivity analysis including only non-septic patients demonstrated that overt DIC on admission was an independent predictor of mortality (HR: 2.54; 95%: 1.24-5.19; p=0.010).

Conclusions: This study suggests that the DIC score may be applied to non-septic ICU populations, and indicates that it is a useful tool for survival prediction, regardless of underlying disease.

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ISTH Congress Abstracts - https://abstracts.isth.org/abstract/the-isth-dic-score-predicts-outcome-in-non-septic-patients-admitted-to-a-cardiovascular-intensive-care-unit/