Abstract Number: PB0798
Meeting: ISTH 2020 Congress
Background: The International Society of Thrombosis and Haemostasis (ISTH) disseminated intravascular coagulation (DIC) score is widely used to predict survival in critically ill – typically septic – patients.
Aims: To investigate whether the ISTH DIC score can be used to predict the 30-day mortality in non-septic patients in an intensive care unit (ICU).
Methods: In this single-center, prospective, observational study we included all patients ≥18 years of age who were admitted to a medical ICU with a focus on cardiovascular diseases between August 2012 and 2013. The DIC score was calculated at admission (DIC-0h) and 72 hours thereafter
(DIC-72h) and classified as overt when ≥ 5.
Results: A total of 233 patients were included in this study (61% male; median age 65.9 years). Overt DIC-0h and overt DIC-72h were associated with a significantly higher 30-day mortality rate at admission (53.8% vs. 22.2% and 50.0% vs. 18.1%; respectively; p < 0.001). A sensitivity analysis including only non-septic patients demonstrated that overt DIC on admission was an independent predictor of mortality (HR: 2.54; 95%: 1.24-5.19; p=0.010).
Conclusions: This study suggests that the DIC score may be applied to non-septic ICU populations, and indicates that it is a useful tool for survival prediction, regardless of underlying disease.
To cite this abstract in AMA style:Grafeneder J, Krychtiuk KA, Buchtele N, Gelbenegger G, Lenz M, Wojta J, Schörgenhofer C, Heinz G, Huber K, Hengstenberg C, Jilma B, Speidl W. The ISTH DIC Score Predicts Outcome in Non-Septic Patients Admitted to a Cardiovascular Intensive Care Unit [abstract]. Res Pract Thromb Haemost. 2020; 4 (Suppl 1). https://abstracts.isth.org/abstract/the-isth-dic-score-predicts-outcome-in-non-septic-patients-admitted-to-a-cardiovascular-intensive-care-unit/. Accessed March 3, 2021.
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