Abstract Number: PB0048
Meeting: ISTH 2020 Congress
Background: The coexistence of any kind of arrhythmia and high level of the blood pressure may increase the risk of the thrombotic complication. Thus, thrombus formation is accompanied by the changes of the levels of biomarkers of vascular affection, cell adhesion molecules, von Willebrand factor (vWF) etc.
Aims: To define the character of interrelationship between the episodes of supraventricular arrhythmias (SVT) and paroxysmal atrial fibrillation (PAF) and the changes of level and activity of von Willebrand factor (vWF) and soluble platelet endothelium cell adhesion molecule-1 (SPECAM-1) in high riskarterial hypertensive (AH) patients.
Methods: We have examined 594 patients with the 5 years period of bservation. Episodes of SVT and PAF were fixed in protocol. During the arrhythmical episodes, the initial levels of SPECAM-1 and vWF were measured.
Results: We have set the reliable increase of the probability of PAF (9,93% [7,98 – 12,19]) than the SVT (3,87% [2,47 – 575]) development, OR=2,74 [1,64 – 4,72] in patients with clinical course of arterial hypertension. There was not found the reliable changes in the levels of SPECAM-1 in the subgroups of SVT, PAF and AH without arrhythmia. However, multivariate ANOVA showed statistically significant differences in initial levels of vWF depending on the presence of arrhythmia. This parameter was significally higher in the group of AH and PAF than in the group of AH and SVT. In these both groups the initial level of vWF was significally higher than in the group with AH only
(p < 0,01).
Conclusions: Study provides evidence that episode both SVT and PAF on the basis of AH are followed by the growth of coagulation activity which may affect the changes of functional state of endothelium and forward to the severity of vessel wall damage which contributes in acute cardiovascular complications.
To cite this abstract in AMA style:Shorikov E, Shorikova D, Shorikov P. The Level of SPECAM-1 and von Willebrand Factor during the Supraventricular Arrhytmia Episodes in Patients with Arterial Hypertension [abstract]. Res Pract Thromb Haemost. 2020; 4 (Suppl 1). https://abstracts.isth.org/abstract/the-level-of-specam-1-and-von-willebrand-factor-during-the-supraventricular-arrhytmia-episodes-in-patients-with-arterial-hypertension/. Accessed September 29, 2023.
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