Background: Nowadays, increasing prevalence of obesity is health concern. Obesity is associated with cardiovascular disease, atherosclerosis, chronic proinflammatory and prothrombotic state. Platelet count, Mean Platelet Volume (MPV) and Platelet Distribution Width (PDW) give information about platelet function and activity. MPV used to measure the platelet size and the PDW measures the variability in platelet size. Increased MPV and PDW indicator of platelet activation.

Aims: To evaluate platelet count, MPV and PDW in obese patients compared with non-obese control.

Methods: The study included 63 obesity patients (28 women and 35 men) and 63 healthy volunteer (28 women and 35 men). Platelet indices including platelet count, MPV and PDW were assayed using complete blood count (CBC).

Results: The mean body mass index (BMI) of the patients was 41.68 kg/m2. The mean Platelet count of the male obese patients was 259.9 ± 56.23 x 10³/ul and in female obese patients was 261 ± 55.22 x 10³/ul. The mean MPV level of the male obese patients was 10.74 ± 0.96 fl and in female obese patients was 10.30 ± 3.10 fl. The mean PDW of the male obese patients was 13.19 ± 2.23 fl and in female obese patients was12.66 ± 4.29 fl. The maen of Platelet count in male non obese was 259.1 ± 54.71 x 10³/ul and in female non obese was 282.8 ± 55.36 x 10³/ul. The mean of MPV level in male non obese was 10.35 ± 0.96 fl and in female non obese was 10.87 ± 3.10 fl. The mean of PDW in male obese was 12.06. ± 1.79 fl and in female non obese was13.53 ± 2.14 fl.

Conclusions: No significant difference was observed between obese patients and non-obese control group. In addition platelet count, MPV and PDW were within normal range and not significantly high or low.

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ISTH Congress Abstracts - https://abstracts.isth.org/abstract/the-platelet-indices-in-patients-with-obesity-in-najran-area-saudi-arabia/