Abstract Number: PB0575
Meeting: ISTH 2021 Congress
Theme: Hemophilia and Rare Bleeding Disorders » Hemophilia - Clinical
Background: Haemophilia patients tend to develop kinesiophobia to avoid movement pain that may lead to physical inactivity, decreased quality of life, and poor mental health. Recent studies suggested that physical exercise can give pain improvement in adult haemophilic arthropathy patients although the results were still inconsistent.
Aims: This study aims to measure the efficacies of physical exercise for reducing pain in adult haemophilic arthropathy patients.
Methods: We did comprehensive online searching databases of Pubmed, ScienceDirect, and The Cochrane Library, to include all relevant studies from January 2000 until January 2021. This study was conducted according to the PRISMA guideline. We included all randomized controlled trials (RCTs) that compared the efficacies between physical exercise and control groups then accessed the changes of pain scale in adult haemophilic arthropathy patients. Physical exercises included in this study are programmed sport therapy (PST), mechanical therapy (MT), and educational therapy (ET). We used the Cochrane Risk-of-bias (RoB 2) tool for accessing bias risks. We conducted analysis to provide standard mean difference (SMD) with 95% confidence interval (CI) using fixed-effect heterogeneity test.
Results: We included 6 RCTs met our eligibility criteria. The MT group shows significant pain reduction compared with the control group (SMD = 1.22, 95%CI 0.67 to 1.76, p<0.0001, I2=0%). Both PST (SMD = 0.35, 95%CI -0.10 to 0.79, p=0.13, I2=0%) and ET groups (SMD = 0.22, 95%CI -0.24 to 0.68, p=0.34, I2=0%) also give pain improvement although not statistically significant. Thus, the overall analysis suggests that physical exercises provide significant pain reduction in adult haemophilic arthropathy patients compared with the control group (SMD = 0.53, 95%CI 0.25 to 0.80, p=0.0002, I2=28%).
Conclusions: Physical exercises have potential benefits for reducing pain in adult haemophilic arthropathy patients. However, further studies are needed to establish the efficacy.
To cite this abstract in AMA style:
Putra BP, Putra FN. The Potential Benefits of Physical Exercises for Reducing Pain in Adult Haemophilic Arthropathy Patients: A Meta-analysis of Randomized Controlled Trials [abstract]. Res Pract Thromb Haemost. 2021; 5 (Suppl 2). https://abstracts.isth.org/abstract/the-potential-benefits-of-physical-exercises-for-reducing-pain-in-adult-haemophilic-arthropathy-patients-a-meta-analysis-of-randomized-controlled-trials/. Accessed March 22, 2024.« Back to ISTH 2021 Congress
ISTH Congress Abstracts - https://abstracts.isth.org/abstract/the-potential-benefits-of-physical-exercises-for-reducing-pain-in-adult-haemophilic-arthropathy-patients-a-meta-analysis-of-randomized-controlled-trials/