Abstract Number: PB2294
Meeting: ISTH 2020 Congress
Theme: Venous Thromboembolism and Cardioembolism » VTE Diagnosis
Background: Previous studies reported that NLR is a simple yet useful biomarker for various clinical conditions. However, the role of NLR in predicting venous thromboembolism (VTE) remains controversial.
Aims: To investigate the association between NLR and VTE including deep vein thrombosis (DVT), pulmonary embolism (PE) and related mortality.
Methods: Major medical databases were systematically searched for observational study which assessed the association of NLR and VTE published until January 2020. The databases were searched with predefined protocol without language restriction based on PRISMA guideline and the selected studies were evaluated using GRADE apporoach. The analysis was performed in RevMan 5.3 (fixed-effects and random-effects model based on heterogeneity test) to provide pooled measures for Risk Ratio (RR), 95% Confidence Interval (95%CI), and weighted mean difference (WMD).
Results: Twenty-four studies were enrolled including 32,047 subjects. Higher NLR was indicated as independent predictors for VTE compared to lower NLR (RR=1.3, p< 0.00001), comprising DVT and PE (RR=1.57, p< 0.00001, and RR=1.08, p=0.005, respectively). There was also an association between higher NLR and risk of mortality after PE episode with RR=1.52 (p< 0.0001), including in-hospital-, short- (30-day), and long-term (>3-years) mortality (RR=1.5 [p=0.02], RR=1.41, p=0.006, and RR=1.65, p=0.000, respectively). VTE-group had a higher mean of NLR compared to control with WMD=1.64 (p< 0.00001), involving PE-group (WMD=2.71,p=0.0006) and DVT-group (WMD=1.08, p=0.004). Among PE patients, PE-related mortality-group had also higher mean of NLR in comparison to survivor-group with WMD=5.35 (p< 0.00001), comprising in-hospital (WMD=2.79, p< 0.0001) and 30-day mortality (WMD=5.88, p< 0.00001).
Conclusions: Higher NLR value was associated with the occurrence of VTE, including DVT, PE, and PE-related mortality. Therefore, the use of the potential value of NLR should be highlighted due to its affordability and accessibility particularly in limited-resource settings.
To cite this abstract in AMA style:
Adda'i MF, Setyani AB, Haposan JH, Haruni AKT. The Prognostic Role of Neutrophil to Lymphocyte Ratio (NLR) in Venous Thromboembolism and Related Mortality [abstract]. Res Pract Thromb Haemost. 2020; 4 (Suppl 1). https://abstracts.isth.org/abstract/the-prognostic-role-of-neutrophil-to-lymphocyte-ratio-nlr-in-venous-thromboembolism-and-related-mortality/. Accessed March 22, 2024.« Back to ISTH 2020 Congress
ISTH Congress Abstracts - https://abstracts.isth.org/abstract/the-prognostic-role-of-neutrophil-to-lymphocyte-ratio-nlr-in-venous-thromboembolism-and-related-mortality/