Abstract Number: PB0474
Meeting: ISTH 2020 Congress
Theme: Diagnostics and OMICs » Biomarkers of Thrombosis and Hemostasis
Background: Red cell distribution width (RDW) is a novel prognostic marker that may reflect an underlying inflammatory state. Recent meta-analyses demonstrated this measurement could be strong predictor in various conditions. Nevertheless, there is no meta-analysis evaluating the role of RDW in prediction of the occurrence of venous thromboembolism (VTE), and related mortality.
Aims: To investigate the association of RDW and VTE including deep vein thrombosis (DVT) and pulmonary embolism (PE) and related mortality.
Methods: Major medical databases were systematically searched for observational study which assessed the association of RDW and VTE published until January 2020. The databases were searched with predefined protocol without language restriction based on PRISMA guideline. The analysis was performed in RevMan 5.3 to provide pooled measures for Risk Ratio (RR) and weighted mean difference (WMD).
Results: Twenty-two studies were enrolled including 6,718 cases and 58,651 controls. Higher RDW was indicated as independent predictors for VTE compared to lower RDW (RR=1.82, p< 0.00001), comprising DVT and PE (RR=1.52, p< 0.00001, and RR=2.05, p=0.002, respectively). There was also an association between higher RDW and risk of mortality after PE episode with RR=1.31 (p=0.001), involving short- (30-day) and long-term (>1 year) mortality (RR=1.79, p=0.04, and RR=1.15, p=0.03, respectively). Compared to lower RDW, higher RDW was also revealed a significant association with unprovoked VTE (RR=2.18, p=0.02). VTE-group had a higher mean of RDW compared to control with WMD=1.13% (p< 0.00001), consisting of PE-group (WMD=0.99%, p< 0.00001) and DVT-group (WMD=1.07%, p< 0.00001). Among PE patients, PE-related mortality group had also higher mean of RDW in comparison to survivor group with WMD=2.04% (p< 0.00001).
Conclusions: Higher RDW value was associated with the occurrence of VTE, including DVT, PE, unprovoked VTE, and PE-related mortality. Therefore, the use of the potential role of RDW should be underlined since it is low-cost and availability, even in the low-resource setting.
To cite this abstract in AMA style:
Adda'i MF, Setyani AB, Haposan JH, Haruni AKT, Soesanto AM. The Prognostic Role of Red Cell Distribution Width in Venous Thromboembolism and Related Mortality [abstract]. Res Pract Thromb Haemost. 2020; 4 (Suppl 1). https://abstracts.isth.org/abstract/the-prognostic-role-of-red-cell-distribution-width-in-venous-thromboembolism-and-related-mortality/. Accessed October 1, 2023.« Back to ISTH 2020 Congress
ISTH Congress Abstracts - https://abstracts.isth.org/abstract/the-prognostic-role-of-red-cell-distribution-width-in-venous-thromboembolism-and-related-mortality/