Abstract Number: VPB1219
Meeting: ISTH 2022 Congress
Theme: Platelet Disorders, von Willebrand Disease and Thrombotic Microangiopathies » Acquired Thrombocytopenias
Background:
Background: Immune thrombocytopenia (ITP) is an autoimmune mediated hemorrhagic disease characterized by thrombocytopenia. Platelet specific antibodies play a key role in platelet destruction.
Aims: This study was aimed to determine whether platelet specific antibodies (including anti-GPIIb/IIIa, anti-GPIb/IX and anti-GPIa/IIa antibodies) are related to the severity of newly diagnosed pediatric ITP.
Methods: This study retrospectively analyzed 154 newly diagnosed ITP patients from October 2016 to September 2021 in Beijing Children’s Hospital. Children who used only glucocorticoids during hospitalization were defined as Severity 1. Children who used glucocorticoids combined with intravenous immunoglobulin (IVIG) and/or single rhTPO were defined as Severity 2. Platelet specific antibodies were detected by PAKAUTO.
Results: When the antibody levels were divided into positive and negative, children with positive anti-GPIIb/IIIa antibody are more severe than children with negative anti-GPIIb/IIIa antibody in newly diagnosed ITP (2=3.969, P=0.046). When the antibody titer ratio was used to reflect the antibody levels, there was no significant difference between platelet specific antibodies and the severity of newly diagnosed pediatric ITP.
Conclusion(s): Anti-GPIIb/IIIa antibody is a sign of higher severity in newly diagnosed pediatric ITP. anti-GPIb/IX and anti-GPIa/IIa antibodies were not found to be related to the severity of ITP.
To cite this abstract in AMA style:
dong S. The relationship between platelet specific antibodies and the severity of newly diagnosed pediatric ITP [abstract]. https://abstracts.isth.org/abstract/the-relationship-between-platelet-specific-antibodies-and-the-severity-of-newly-diagnosed-pediatric-itp/. Accessed September 24, 2023.« Back to ISTH 2022 Congress
ISTH Congress Abstracts - https://abstracts.isth.org/abstract/the-relationship-between-platelet-specific-antibodies-and-the-severity-of-newly-diagnosed-pediatric-itp/