Abstract Number: PB0275
Meeting: ISTH 2021 Congress
Theme: COVID and Coagulation » COVID and Coagulation, Clinical
Background: Despite the diagnostic role of D-dimer in the identification of pulmonary thrombembolism (PE), many questions still remain regarding its potential role in the clinical prognosis of these conditions. In recent times, PE has taken on new importance, as a common clinical exacerbation following disease state of COVID-19.
Aims: Paper aims to assess the predictive value of D-dimer when combined with other parameters (prothrombin time, platelet count, ultrasound parameters and risk factors) in the long term prognosis of patients with PE. Additionally, a group of patients with COVID-19 were tested for D-dimer to establish a prognostic role for the biomarker.
Methods: Here we present, stable, clear data from a national registry taken from multiple centers. 29 participants (1st group on age 58,7 + 9) were recruited on hospitalization for moderate to severe COVID-19 and followed up during hospitalization. 84 patients with PE (2nd group, on age 60.3 + 12.5), were selected and followed up for 6 months.
Results: Significant differences in D-dimer levels at admission were noted in COVID-19 patients who would require artificial ventilation (1250 + 210 ng/ml) compared to those who did not (650 + 175ng/ml respectively; p < 0.05). However multivariate analysis did not show independent value of D-dimer in a relation to clinical course of these pts. Number of comorbidities was presented as a risk factor for poorer COVID-19 outcomes.
In PE pts regression analysis revealed that D-dimer level (mean value 2654.5+420,3ng/ml) is a predictor for length of hospitalization (β 0,25, p 0,05), together with right ventricular diameter as a factor for duration of anticoagulation.
Conclusions: Our results confirmed the predictive value of D-dimer when added on top of echocardiographic parameters in relation to the prognosis of patients with pulmonary embolism. This biomarker might be superior to other thrombotic biomarkers in COVID-19 pts in a relation to their clinical course.
To cite this abstract in AMA style:
Bosevski M, Krstevski G, Dodic E, Kapsarov K, Petkovic N, National Registry on Venous Thrombembolism . The Role of D-dimer in Prognosis of Patients with Pulmonary Thrombembolism: Some Aspects for COVID-19 [abstract]. Res Pract Thromb Haemost. 2021; 5 (Suppl 2). https://abstracts.isth.org/abstract/the-role-of-d-dimer-in-prognosis-of-patients-with-pulmonary-thrombembolism-some-aspects-for-covid-19/. Accessed March 22, 2024.« Back to ISTH 2021 Congress
ISTH Congress Abstracts - https://abstracts.isth.org/abstract/the-role-of-d-dimer-in-prognosis-of-patients-with-pulmonary-thrombembolism-some-aspects-for-covid-19/