Background: Deep vein thrombosis of unusual location refers to deep vein thrombosis of location other than the lower limbs. They are infrequent and, unlike thrombosis of the lower limbs, they most often occur in an underlying anomaly.
Aims: The aim of our work is to determine the etiological profile of deep vein thromboses of unusual location.
Methods: A retrospective study of 146 files of patients with thromboembolic venous disease over a 5-year period (2013-2017).
Results: Twenty-one cases (14.3%)had unusual sites venous thrombosis: 9men and 12women with an average age of 37.1years. DVT of the abdominal veins was dominant observed in 8patients with 1case of portal thrombosis, 1case of splenic venous thrombosis, 4cases of mesenteric venous thrombosis, 1case of the renal vein, and 4cases of the ovarian vein. DVT of the inferior vena cava was observed in 6patients, that of the cerebral veins in 2cases and that of the upper limbs in 1case. Risk factors for abdominal venous thrombosis were dominated by intra-abdominal surgery (4cases), cirrhosis with portal hypertension (2cases), inflammatory bole disease (2cases) and a history of thrombosis (4cases). The other venous thrombosis of unusual site had occurred following bed rest (7 cases), surgery (6cases), post partum (5 cases) and in the context of Behçet’s disease in 1case.An etiological assessment, carried out in all cases had shown that constitutional thrombophilia was observed in 10patients (47.6%), dominated by resistance to activated protein C (APCR). (APCR) was isolated in 8cases, associated with protein S deficiency in 1case and antiphospholipid syndrome in 1 case. Unusual venous thromboses associated with RPCA were located in the abdominal veins in 4cases, the inferior vena cava in 3 cases and the ovarian veins in 3 cases. Acquired thrombophilia (antiphospholipid syndrome) was observed in 4patients (19%).
Conclusions: Thrombophlebitis with unusual localisation is a serious condition that requires exploration and adequate symptomatic and etiological management.
To cite this abstract in AMA style:
Chabchoub I, Ben Salah R, Megdiche F, Kallel C, Bahloul Z. The Role of Thrombophilia in Deep Vein Thrombosis of Unusual Sites [abstract]. Res Pract Thromb Haemost. 2021; 5 (Suppl 2). https://abstracts.isth.org/abstract/the-role-of-thrombophilia-in-deep-vein-thrombosis-of-unusual-sites/. Accessed March 22, 2024.« Back to ISTH 2021 Congress
ISTH Congress Abstracts - https://abstracts.isth.org/abstract/the-role-of-thrombophilia-in-deep-vein-thrombosis-of-unusual-sites/