Abstract Number: PB2341
Meeting: ISTH 2020 Congress
Theme: Venous Thromboembolism and Cardioembolism » VTE Epidemiology
Background: There are numerous researches dealing with correlation between the seasons and climatic factors and pathogenesis of thromboembolic disease (VTE).
Aims: To investigate the influence of the season in the occurrence of VTE.
Methods: Retrospective, monocentric comparative study, having collected patients admitted for VTE between 2000 and 2018 . We divided patients in 4 groups: group 1 included patients in whom VTE was diagnosed in autumn, group 2 in summer, group 3 in winter and group 4 in spring. We compared frequencies of VTE in four groups and their epidemiological, clinical, etiological and evolutive characteristics.
Results: The total population consisted of 1553 subjects (826 men, 727 women). The mean age of our population was 55.03 years old.
Overall, the number of VTE diagnoses was higher in winter compared to other seasons with the largest difference between winter and spring (17.1% higher).
There were no significant differences between 4 groups in gender ratio. No significant seasonal differences were observed in elderly patients (more than 65 years old). Risk factors are summarized in table 1. Non provoked VTE were significantly more frequent in spring and autumn (p=0.004). Frequencies of unsual location of VTE were significantly higher in group 4 than other groups (p=0.001).
Among patients with pulmonary embolism, no significant difference between groups. Thus, constitutional thrombophilia was the only etiology with a significant higher frequency in autumn (p=0.003). Recurrence were more frequent in group 1 and 4 (12.8% and 17%) versus 9.4 and 8.8% in groups 2 and 3 (p=0.019). Post phlebitis syndrome was significantly less frequent in spring (p=0.002). Seasonal variation was significantly contributive in VTE incidence.
Conclusions: In our series, VTE were more frequent in winter with significant differences between seasons.Further prospective researches could aim on testing the correlation between both climatic and thrombotics factors and the pathogenesis of VTE.
| Risk factors | Group 1 | Group 2 | Group 3 | Group 4 | p |
| Bed rest | 15.7% | 23.8% | 21.5% | 22.4% | NS |
| Varicose veins | 15.7% | 15.6% | 14.7% | 10.2% | NS |
| obesity | 19.9% | 24.7% | 24.5% | 18.1% | 0.055 |
| tobacco | 36.2% | 38.1% | 29.5% | 36.2% | 0.001 |
| post-partum | 13.5% | 14.7% | 9.2% | 3.8% | 0.038 |
| Surgery | 9.6% | 11.3% | 12% | 11.4% | NS |
| Neoplasia | 13.8% | 15.8% | 13.3% | 10.2% | NS |
| Constitutional thrombophilia | 9.3% | 6.3% | 4% | 5.3% | 0.003 |
| Antiphospholipid syndrome | 2.6% | 0.7% | 1.6% | 2.4% | NS |
[Table 1: comparaison of frequencies of thrombotic factors between groups]
To cite this abstract in AMA style:
Skouri W, Said F, Naceur I, Baccouche H, Lamloum M, Ben Ghorbel I, Khanfir M, Houman MH, Ben Romdhane N. The Season Role in the Occurrence of Thromboembolic Disease [abstract]. Res Pract Thromb Haemost. 2020; 4 (Suppl 1). https://abstracts.isth.org/abstract/the-season-role-in-the-occurrence-of-thromboembolic-disease/. Accessed September 27, 2023.« Back to ISTH 2020 Congress
ISTH Congress Abstracts - https://abstracts.isth.org/abstract/the-season-role-in-the-occurrence-of-thromboembolic-disease/