Abstract Number: LPB0144
Meeting: ISTH 2021 Congress
Background: Thrombocytopenia is an important finding encountered during pregnancy, which is second only to anemia. It is diagnosed in approximately 5-6% of pregnancies. Increased platelet turn-over or dilutional effect of increased blood volume during pregnancy may be responsible for thrombocytopenia.
Aims: The study aimed to evaluate the causes of thrombocytopenia in pregnancy and its management along with the outcome.
Methods: The study aimed to evaluate the causes of thrombocytopenia in pregnancy and its management along with the outcome.
Results: A total of 130 pregnant women with thrombocytopenia were enrolled, with the mean age being 27.3±4.64 years. Mean platelet counts at baseline were 48.0±24. Main clinical manifestations at baseline included: anemia 65.9%, bruises 23.25%, and edema 9.3%. Causes of thrombocytopenia were: gestational thrombocytopenia (GT) 65 (50%), acute fatty liver 4 (3.1%), pre-eclampsia in 10 (7.7%) and eclampsia 6 (4.6%). Causes not specific to pregnancy include 24 (18.4%) cases of ITP, hepatitis C and nutritional deficiency was reported in 8 (6.1%) patients each. 17 (70.8%) ITP patients received treatment with steroids with complete response in 64.4% of patients as presented in Table 1. Maternal outcomes in patients of thrombocytopenia as displayed in Table 2. Overall, 35 (27%) women with bleeding symptoms and platelet counts <50×109/L received platelet transfusions.
|Prednisolone + IVIG||2(11.7%)||1(5.8%)||1(5.8%)|
SPECIFIC TO PREGNANCY
NOT SPECIFIC TO PREGNANCY
Conclusions: The study shows that pre-eclampsia and eclampsia are serious conditions with high risk for complications, while GT is a benign and the most common cause of thrombocytopenia which requires no active treatment.The other causes are in between and require individualized management.
To cite this abstract in AMA style:Borhany M, Abid M, Zafar S, Shamsi T. Thrombocytopenia in Pregnancy: Identification and Management at a Reference Centre in Pakistan [abstract]. Res Pract Thromb Haemost. 2021; 5 (Suppl 2). https://abstracts.isth.org/abstract/thrombocytopenia-in-pregnancy-identification-and-management-at-a-reference-centre-in-pakistan/. Accessed August 16, 2022.
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