Background: Evidence suggested that severe COVID-19, a condition associated with a high mortality rate, is aggravated by significant coagulopathy which manifests in the form of microthrombosis and venous thromboembolism(VTE). Therefore,easy and accurate markers are required to assess coagulopathic changes in Covid-19 patients as the basis for providing prophylactic anticoagulant therapy to prevent thrombosis.

Aims: Our study aimed to assess the potential predictor of Thromboelastography(TEG) to estimate the outcome of COVID-19 patients

Methods: A cross-sectional study approved by local the ethical committee, was conducted in Dr.Saiful Anwar Hospital. The potential interest data, retrieved from medical records, were extracted, ie:TEG, thrombocytes levels, the severity of COVID-19 patients, and themortality rate of COVID-19 patients. The diagnosis of COVID-19 was confirmed by reverse-transcription polymerase chain reaction(RT-PCR). The comparison between TEG and the risk of mortality among patients with COVID-19 was analyzed using multiple logistic regression. We applied Graphad Prism version 9 (Graphad, Sandiego,CA) to analyze the data

Results: A total of 63 patients, employed from medical records, were included in this study, in which the survival rate was 65% and 22 patients died. Our study population between groups was age and sex-matched(Tab1). Our current findings revealed that hypercoagulation TEG was associated with 12,67-fold increase risk of mortality compared to those normocoagulation or hypocoagulation TEG(Fig1). Moreover, we also found that, among all TEG parameters, Lys30 was the only parameter having the greatest pivotal impact to govern the mortality of COVID-19 patients. We found that higher levels of Lys30 (MD95%CI: 26.90[13.34-40.47]) was associated with increase risk of mortality among patients with COVID-19(Fig1). On the other hand, our study also confirmed that the levels of CI and MA were observed higher in mortality group than in survival group

Conclusion(s): Our current study indicated that hypercoagulation TEG, excess fibrinolysis (Lys30), CI and MA increased the risk of mortality among patients with COVID-19

Table 1. Baseline Characteristics Subject

Table 1. Baseline Characteristics Subject

Figure 1. Summary of the Proportion between Status of Coagulability -A,B,C- and The Association between TEG parameters and the risk of Mortality among patients with Covid-19

Figure 1. Summary of the Proportion between Status of Coagulability -A,B,C- and The Association between TEG parameters and the risk of Mortality among patients with Covid-19

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ISTH Congress Abstracts - https://abstracts.isth.org/abstract/thromboelastography-teg-as-an-outcome-predictor-marker-of-covid-19-patients-in-malang-indonesia/