Background: Thromboembolic venous disease (TVD) is a multifactorial pathology. Thrombophilia, which is a state of hypercoagulability linked to constitutional and/or acquired haemostasis abnormalities, is one of the main etiological factors of TVD.
Aims: The aim of our work is to study the thrombophilia profile in a series of patients hospitalised for TVD.
Methods: A monocentric retrospective study over a period of 5 years (2013-2017). All the records of patients hospitalised for VTE and for whom an etiological assessment of thrombophilia was carried out were pooled.
Results: There were 146 patients: 69men (47.3%) and 77women (52.7%) with a sex ratio (M/F) of 0.89. The average age of our patients was 42.5years. 62patients (42.46%) had a thrombophilic anomaly: 46cases (31.5%) of isolated constitutional thrombophilia, 13cases (8.9%) of isolated acquired thrombophilia, 3cases (2.05%) of mixed thrombophilia.
During constitutional thrombophilia, antithrombin III deficiency was found in 1case (0.68%), Protein S deficiency in 5cases (3.4%) and Protein C deficiency in 2cases (1.36%). Resistance to activated protein C was observed in 45/146 patients (30.82%). Acquired thrombophilia was diagnosed in 16patients (11%). The associated etiologies were SLE (1case), Behçet’s disease (1case) and cancer and/or its treatment (1case).
Out of a total of 124cases of deep vein thrombosis of the lower limbs, hereditary thrombophilia was noted in 42cases (33.8%), acquired thrombophilia in 12cases(9.6%) and mixed thrombophilia in 3cases(2.4%). PRCa was the most common constitutional abnormality observed during lower limb DVT, noted in 36patients(27%). During the unusual venous thromboses represented by 21cases, hereditary thrombophilia was noted in 9cases(42.8%), acquired thrombophilia in 3cases(14.2%) and mixed thrombophilia in 1case(4.7%). The most frequent hereditary abnormality was CPRa. It was isolated in 8patients.
Conclusions: Thrombophilia is one of the major causes of VTE. The indication of the thrombophilia assessment must be known by the clinician given its clinical involvement and its therapeutic consequences in a patient suffering from VTE.
To cite this abstract in AMA style:Chabchoub I, Ben Salah R, Megdiche F, Kallel C, Bahloul Z. Thrombophilia and Thromboembolic Venous Disease in Southern Tunisia [abstract]. Res Pract Thromb Haemost. 2021; 5 (Suppl 2). https://abstracts.isth.org/abstract/thrombophilia-and-thromboembolic-venous-disease-in-southern-tunisia/. Accessed November 29, 2023.
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