Background: Speaking of biological risk factors for venous thromboembolism in the elderly women who are at high risk of thrombosis, still are few data available. Thrombophilia is considered one of the risk factors for venous thrombosis.

Aims: The aim of the present study, was to assessed the prevalence of PAI1, MTHFR C667T mutation, MTHFR A1298C mutation, factor V Leiden R506Q mutation and G20210A prothrombin gene variant, in women patients over 65 years who were referred to us for thrombophilia testing and who present venous thromboembolic disease.

Methods: Sixty four women patients were included in the group.

Results: For PAI 1 we found 20 patients as normal, 20 were found heterozygous carriers and 12 homozygous carriers. Regarding factor V Leiden R506Q mutation we found 52 patient as normal, and 12 heterozygous carriers and for MTHFR C667T mutation there were 24 normal, heterozygous carriers 33 and 7 patients homozygous carriers. MTHFR A1298C mutation was normal for 35 patients, heterozygous carriers for 27 and 2 homozygous carriers. G20210A prothrombin gene variant was normal for 63 patient and only 1 was heterozygous carrier.

Conclusions: The identification of a thrombophilia can lead to overestimating the risk of thrombosis. thrombophilia testing is rarely useful following venous thromboembolism, possible to identify the risk of recurrence in some patients in whom the thromboembolic event was unexplained.

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ISTH Congress Abstracts - https://abstracts.isth.org/abstract/thrombophilic-abnormalities-screening-in-elderly-women-patients-with-venous-thrombosis/