Abstract Number: PB0066
Meeting: ISTH 2022 Congress
The SARS-CoV-2 infection has been associated with a potentially severe inflammatory reaction, endothelial damage, and coagulation cascade activation that cause thrombosis.
There is limited information on the thrombosis and anticoagulant therapy in children with COVID-19 and no design pediatric-specific recommendations for thromboprophylaxis in COVID-19 are available.
Aims: This study aims to evaluate the outcome of thromboprophylaxis in children less than 18-year-old with COVID-19 infection.
Methods: A retrospective study was conducted on 184 pediatric patients with confirmed COVID-19 infection in southern Iran. A designed questionnaire was made to collect all demographic, clinical, and laboratory data. According to World Health Organization, the patients were classified as asymptomatic/mild, moderate, severe, and critically ill.
Results: The mean age of the patients was 7.04 ± 5.9 (1 week to < 18 years), 96 boys and 88 girls. Overall, 33 patients received anticoagulant therapy. The median of D-dimer was insignificantly higher in patients taking anticoagulant therapy compared to another group. (P=0.133). All variables were comparable between the two groups. The mortality rate was non-significantly higher in patients who were not treated with anticoagulants (14%) compared to the thromboprophylaxis group (9%) (P=0.567). In the critical group, two patients were complicated with disseminated intravascular coagulation (2.56%), one patient (1.28%) with deep vein thrombosis despite taking thromboprophylaxis, and one (1.28%) with pulmonary thromboembolism while the patient did not take anticoagulant during hospital admission Table 1).
Conclusion(s): Our data showed a lower rate of thrombosis (1.4% in moderate to severe/critically ill patients) than adult patients with COVID-19 infection. Moreover, higher mortality rate was observed in patients without anticoagulant therapy, though statistically not significant. It may underline the role of anticoagulants in moderate to severe/critically ill children with COVID-19 infection. Expert opinion and personal experience are necessary, while we have a significant knowledge gap in understanding COVID-19-associated coagulopathy and thrombotic risk in children.
To cite this abstract in AMA style:Karimi M, Sanaei Dashti A, Haghpanah S, Mansoori Y, Zarei T, Amanati A, Bordbar M. Thromboprophylaxis outcome in childhood SARS-CoV-2 infection: A single-center experience [abstract]. https://abstracts.isth.org/abstract/thromboprophylaxis-outcome-in-childhood-sars-cov-2-infection-a-single-center-experience/. Accessed September 21, 2023.
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