Abstract Number: VPB0531
Meeting: ISTH 2022 Congress
Background: Under the action of excessive stressors of different nature, hemostasis can respond by forming a state of thrombotic readiness.
Aims: The paper aims to assess the effect of a single intensive physical exercise of varying duration on the hemostasis system, microvasculature, and endothelium of rats.
Methods: The hemostasis system and microvasculature were investigated in 60 mature male Wistar white rats after a 4-hour and 8-hour physical exercise on a rat treadmill.
Results: It was found that a 4-hour exercise resulted in an increase in the aggregation function of platelets with a subsequent increase in their number and hypercoagulation against the decrease in plasma anticoagulant activity. An 8-hour exercise increased the negative changes identified before. Thus, there was an increase in soluble fibrin monomer complexes, a decrease in fibrinogen and platelets in the blood, a decrease in plasma anticoagulant and fibrinolytic activity, the development of endothelial dysfunction and congestive phenomena in the microcirculation area.
Conclusion(s): The increase in the duration of stress exposure training from 4 to 8 hours leads to an increase in the severity of signs of the thrombotic state of readiness.
To cite this abstract in AMA style:Blazhko A. Thrombotic state of readiness with increase of physical activity [abstract]. https://abstracts.isth.org/abstract/thrombotic-state-of-readiness-with-increase-of-physical-activity/. Accessed February 25, 2024.
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