Abstract Number: PB1078
Meeting: ISTH 2020 Congress
Theme: Hemophilia and Rare Bleeding Disorders » Hemophilia - Clinical
Background: Hemophilic arthropathy is a prevalent disease in patients with Hemophilia A and B that causes negative consequences on joint function, ability to perform daily activities, chronic pain and impairment on quality of life. Treatment of advanced cases consists of total arthroplasty with joint replacement, even in young patients, to restore their daily activities.
Aims: The aim of this study is to evaluate clinical results and impact onquality of life in hemophilic patients having advanced knee arthropaty and compare pre and post surgery data.
Methods: Seven patients were invited to participate, all Hemophilic A(6) and B(1), with indication of total knee arthroplasty (mean 37y, median 35y, range:30-47y). After patients signed the informed consent, a general questionnaire was applied, Haem-A-Qol, FISH and HJHS scores, previous the surgery. Six months later, it was applied again for re-evaluation. Bleeding rateswere also analyzed, pre and post surgery factor concentrate consumption.
Results: Five of seven patients were analyzed, because two of them didn´t reach 6 months after surgery. The median rate of AJBR was 4.8 (range 0 to 11) and 1.21 (range 0 to 4); HJHS was 23 (range 18 to 31) and 13 (range 11 to 17); FISH score was 19.4(range 18 to 21) and 23.8 (range 21 to 29) , Haem-A -QOL was 33.32%(range 15,7 to 41,12) and 29% (range 9.2 to 34.16) pre and post surgery.
Conclusions: Despite the moderate increase in HAEM-A QOL, due to other arthropathies that these patients have, when domain 1 and 2 related to physical health and the burden of hemophilia were analized, we found significant results. Regarding HJSH and FISH scores, all patients presented improvement, with positive impact in their daily activities.
[Evaluation of AJBR, HAEM-A -QOL, FISH and HJHS before surgery]
[Evaluation of AJBR, HAEM-A -QOL, FISH and HJHS after surgery]
To cite this abstract in AMA style:
Nunes Loureiro Prezotti A, Souza Mario Duarte J, Soraya Marcondes S, Vendramini Orletti MDPS, Maria do Carmo Rocha D, Rocha Neto A, Calatrone Altoe B, Souza Arnoni L, Prucoli B, Louredo G, Silva Pacheco CR, Lacerda Montezi L. Total Knee Arthroplasty in Patients with Hemophilia A and B: Impact on Quality of Life [abstract]. Res Pract Thromb Haemost. 2020; 4 (Suppl 1). https://abstracts.isth.org/abstract/total-knee-arthroplasty-in-patients-with-hemophilia-a-and-b-impact-on-quality-of-life/. Accessed October 1, 2023.« Back to ISTH 2020 Congress
ISTH Congress Abstracts - https://abstracts.isth.org/abstract/total-knee-arthroplasty-in-patients-with-hemophilia-a-and-b-impact-on-quality-of-life/