Abstract Number: PB0888
Meeting: ISTH 2020 Congress
Theme: Hemophilia and Rare Bleeding Disorders » Hemophilia - Clinical
Background: Hyaluronate is an important component of articular hyaline cartilage; participating in its nutrition and recovery, it helps to ease joint mobility and eliminate pain. The binding of hyaluronic acid to a specific component of cartilage tissue – chondroitin sulfate – helps to retain water in the cartilage, which increases its elasticity and improves its shock-absorbing properties.
Aims: The purpose of the study was to study the effects of hyaluronic drugs in hemophilic osteoarthritis.
Methods: In 35 patients with hemophilia, to improve joint function and to compensate for the deficiency of intraarticular fluid, intra-articular administration of preparations containing hyaluronic acid was used. Of 35 patients, 10 patients had X-ray osteortrosis of the III-IV stage, 20 patients of the III stage and 5 patients of the II-III stage. The age of patients ranged from 17 to 55 years. Severe dysfunction of the joints was observed in patients with stage III-IV osteoarthrosis.
Results: Hyaluronic acid preparations have elasticity and viscosity, the therapeutic effect is associated with the replenishment of viscosity. Preparations containing hyaluronic acid were administered intraarticularly 2.5 ml 1 time per week No. 3. It is noted that the introduction of the drug does not cause adverse effects, inflammation and relapse of hemarthrosis. Joint functions have improved in 80% of patients.
Conclusions: Thus, these drugs improve the physiological and rheological status of the tissues of the affected joint and protect the articular cartilage from mechanical damage. The introduction of hyaluronic acid into the joint cavity eliminates (reduces) these negative consequences, replenishing the amount of synovial fluid, increasing its viscosity. Friction of the articular surfaces decreases, the shock-absorbing function improves, movements in the affected joint become less painful, their amplitude increases.
To cite this abstract in AMA style:
Makhmudova A, Berger I, Ashurova L, Akhrarova N, Madasheva O. Treatment of Hemophilic Arthropathy with Hyaluron [abstract]. Res Pract Thromb Haemost. 2020; 4 (Suppl 1). https://abstracts.isth.org/abstract/treatment-of-hemophilic-arthropathy-with-hyaluron/. Accessed September 29, 2023.« Back to ISTH 2020 Congress
ISTH Congress Abstracts - https://abstracts.isth.org/abstract/treatment-of-hemophilic-arthropathy-with-hyaluron/