Abstract Number: PB1212
Meeting: ISTH 2021 Congress
Theme: Venous Thromboembolism » VTE Epidemiology
Background: Cerebral venous sinus thrombosis (CVST) is a rare manifestation of venous thromboembolism (VTE). The estimated CVST incidence in adults is 2-5 per million cases. Among potential risk factors for CVST are congenital and acquired thrombophilia.
Aims: Evaluation of the prevalence of congenital thrombophilia, antiphospholipid syndrome (APS) and other risk factors for CVST in a large cohort of patients.
Methods: Our study comprised 255 patients with definitive diagnosis of CVST: 188 women and 67 men, mean age 39 (14-83) years. Medical interview included family history of VTE, age and presence of environmental thrombosis risk factors (pregnancy, delivery, oral contraceptives and hormone replacement therapy (OCPs/HRT), infection, neoplasm) at CVST diagnosis. Laboratory tests comprised thrombophilic defects: deficiency of antithrombin, protein C and protein S as well as factor V Leiden and prothrombin gene mutation G20210A and antiphospholipid antibodies.
Results: Forty-two (16.5%) patients had congenital thrombophilia and fourteen (5.5%) were diagnosed with APS. In 11 (4.3%) patients myeloproliferative neoplasms (MPN) was investigated due to complete blood count aberrations and in 9 of them (3.5% of all patients) JAK-2 V617F positive MPN was confirmed (Essential Thrombocytemia (ET) in 5, Policythemia Vera (PV) in 1, ET/Primary Myelofibrosis (PMF) in 1, PMF in 1 and MF post PV in 1). One patient had triple-negative ET and one – Myelodysplastic Syndrome/MPN. Two patients (0.8%) had congenital thrombophilia coexistent with MPN. At the time of CVST diagnosis 86/188 (45.7%) women were taking OCPs/HRT, while in twenty-nine (15.4%) females CVST occurred during pregnancy or at delivery. Thirty one patients (12.1%) reported a positive family history of VTE.
Conclusions: In the study patients the main risk factors for CVST were oral contraceptives and hormone replacement therapy as well as congenital thrombophilia, pregnancy and delivery.
To cite this abstract in AMA style:
Gwozdowska A, Odnoczko E, Baran B, Windyga J, Gwozdowska A, Odnoczko E, Baran B, 1 , Windyga 2. Trombophilia and Other Risk Factors of Cerebral Venous Sinus Thrombosis in 255 Patients [abstract]. Res Pract Thromb Haemost. 2021; 5 (Suppl 2). https://abstracts.isth.org/abstract/trombophilia-and-other-risk-factors-of-cerebral-venous-sinus-thrombosis-in-255-patients/. Accessed March 22, 2024.« Back to ISTH 2021 Congress
ISTH Congress Abstracts - https://abstracts.isth.org/abstract/trombophilia-and-other-risk-factors-of-cerebral-venous-sinus-thrombosis-in-255-patients/