Abstract Number: PO110
Meeting: ISTH 2021 Congress
Theme: Arterial Thromboembolism » Atherosclerosis
Background: Three mechanisms are responsible for the development of restenosis: elastic recoil, intimal hyperplasia and late vascular constriction, all grouped under the catch phrase “negative remodeling”. Neointimal hyperplasia is usually defined in an artery as thickening of the intimal layer after an injury such as different angioplasty methods, mechanical atherectomy or surgical repair. The balloon angioplasty methods that are currently in use, cause to inflammation and subsequent restenosis.
Aims: The aim of this study was to evaluate the effect of combined electrohydraulic shock wave therapy and 125I- mediated gamma-intravascular brachytherapy on inflammation and restenosis reduction after balloon angioplasty of the animal occluded common carotid artery model, wherein diagnostic ultrasound is adjuncted with angioplasty and combination therapy system, with a goal of increased safety.
Methods: Briefly, Golden Syrian Hamsters were submitted to common carotid artery advanced atherosclerotic occlusion by primary perivascular Co2 thermal laser injury followed by a 2% cholesterol- rich diet for six weeks. Histopathology results showed the formation of a thick- cap fibroatheromatic plaque, resulted to occlusion in all of the hamsters’ arteries. Then treatment group (n= 10) underwent B- mode ultrasound- guided balloon angioplasty followed by combined shock wave (V= 12Kv, F= 0.5 Hz, Impulses= 120) therapy and gamma-intravascular brachytherapy (125I-, 18 Gy) and simultaneously ultrasound imaging.
Results: Results from histopathology showed a significant reduction in the mean value for macrophages and smooth muscle hyperplasia cells density after balloon angioplasty in the treated group compared with the other groups (p<0.05).
Conclusions: Anti- inflammatory effect of shock waves accompanied by apoptotic effect of gamma brachytherapy, can cause to reduce the inflammation and smooth muscle hyperplasia cells in the intimal layer. These findings provide the basis for developing of combined low level electrohydraulic focused shock wave therapy and 125I- mediated gamma-intravascular brachytherapy for a successful clinical application in the treatment of restenosis after balloon angioplasty.
To cite this abstract in AMA style:
Mehrad H, Ahmadi Noubari H. Ultrasound-guided Balloon Angioplasty of Occluded Artery Accompanied by Combined Electrohydraulic Low Level Shock Wave Therapy and 125I- Mediated Gamma-intravascular Brachytherapy [abstract]. Res Pract Thromb Haemost. 2021; 5 (Suppl 2). https://abstracts.isth.org/abstract/ultrasound-guided-balloon-angioplasty-of-occluded-artery-accompanied-by-combined-electrohydraulic-low-level-shock-wave-therapy-and-125i-mediated-gamma-intravascular-brachytherapy/. Accessed March 22, 2024.« Back to ISTH 2021 Congress
ISTH Congress Abstracts - https://abstracts.isth.org/abstract/ultrasound-guided-balloon-angioplasty-of-occluded-artery-accompanied-by-combined-electrohydraulic-low-level-shock-wave-therapy-and-125i-mediated-gamma-intravascular-brachytherapy/