Abstract Number: PB0680
Meeting: ISTH 2020 Congress
Background: Developmental hemostasis is known as the evolution with age of the hemostatic system starting in fetal life and throughout childhood. The process involves a dynamic change in the levels of procoagulation and anticoagulation proteins. Developmental hemostasis creates a challenge for clinicians in the diagnosis and treatment of coagulation disorder in the pediatric population. Therefore, specific age-related reference ranges are necessary for an accurate diagnosis and management. However, reference ranges are analyzer and reagent dependent; and it is estimated that only a small number of laboratories worldwide use adequately established age-, reagent- and analyzer-specific reference ranges. Inappropriate clinical use of reference ranges leads to both over diagnosis and missed diagnosis of the child.
Aims: We aimed to create a platform for practitioners to compare their patients´ results with appropriate age-, reagent- and analyer-specific reference ranges. In addition, a platform for clinicians to contribute data towards a worldwide harmonized reference ranges for hemostatic parameters was established.
Methods: Data on developmental hemostasis from the literature was extracted and pooled into age-, reagent- and analyer-specific reference ranges. A mobile application was created as a platform to present the data conveniently. In addition, a user-friendly form was embedded for clinicians to contribute data towards a worldwide harmonized reference ranges for hemostatic parameters.
Results: Two clinically relevant proteins, alpha-2-macroglobulin and protein C were analyzed. Data from xx identified articles in the literature was collected and presented in the developing mobile application. Inadequate sample size of each age group and differences in analyzer use were noticed. Link to the app prototype: http://bit.ly/prototype_clotrefs
Conclusions: The CLOTSref mobile application is a promising platform for practicioners in pediatric hematology to provide the best possible standard of care based on appropriate reference ranges. In addition, it allows clinicians to contribute data towards a worldwide harmonized reference ranges for hemostatic parameters.
To cite this abstract in AMA style:Tieu PT, Chung J, Nguyen TQH, Matino D, Moffat K, Chan A. Updated CLOTSref: A Mobile Application for Standardized Reference Ranges in Developmental Hemostasis [abstract]. Res Pract Thromb Haemost. 2020; 4 (Suppl 1). https://abstracts.isth.org/abstract/updated-clotsref-a-mobile-application-for-standardized-reference-ranges-in-developmental-hemostasis/. Accessed March 4, 2024.
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ISTH Congress Abstracts - https://abstracts.isth.org/abstract/updated-clotsref-a-mobile-application-for-standardized-reference-ranges-in-developmental-hemostasis/