Abstract Number: PB0389
Meeting: ISTH 2021 Congress
Background: Thrombocytopenia and thrombocytosis are two common abnormalities found in results of complete blood count (CBC). Unlike red blood cell (RBC) indices and reticulocyte count (RC), the interpretation of platelet indices and immature platelet fraction (IPF) is less understandable in various number of platelet count (PLT) and the benefit of using those parameters in clinical setting particularly in pediatric population is inconclusive.
Aims: To find the way to interpret and the utility of platelet parameters in pediatric outpatient setting
Methods: A retrospective study was conducted to review the results of CBC and platelet indices including platelet distribution width (PDW), mean platelet volume (MPV) and immature platelet fraction (IPF) in Pediatric Clinic, Chiang Mai University Hospital between July and December 2020. The CBC, platelet indices and IPF were performed by Sysmex XN-350TM.
Results: Among 237 CBC tests, there were 163 results with normal PLT, 45 with thrombocytosis (PLT > 450,000/mm3) and 29 with thrombocytopenia (PLT < 150,000/mm3). The PDW and MPV were shown only in 162 results (68%). The median (min-max) PDW and MPV in reports of normal PLT [10.1 (7.3-25.6)% and 9.9 (7.6-13.6) fL, respectively] and thrombocytosis [10.3 (8.1-16.6)% and 9.8 (8.1-12.9) fL, respectively] were lower than in those of thrombocytopenia [13.6 (8.8-22.1)% and 12 (8.5-13.8) fL, respectively], (P=0.001 and <0.001, respectively). Moreover, the median (min-max) IPF in reports of normal PLT [2 (0-9.6)%] and thrombocytosis [1.8 (0.2-8.1)] was lower than one of thrombocytopenia [7.4 (1.3-39.6)%], (P<0.001). In thrombocytopenia group, the median PDW and IPF were higher in ones with increased consumption (19.1 and 12.8%, respectively) rather than ones with underproduction (11.3 and 2.6%, respectively) (P=0.018 and 0.009, respectively).
Conclusions: Though increased platelet indices and IPF are the findings in pediatric patients who have thrombocytopenia especially in ones who have thrombocytopenia due to increased consumption, the platelet indices are shown only two-third of CBC reports.
To cite this abstract in AMA style:Natesirinilkul R, Manowong S, Saihikam P. Utility of Platelet Parameters in Pediatric Outpatient Setting: Experience from a Single Institution [abstract]. Res Pract Thromb Haemost. 2021; 5 (Suppl 2). https://abstracts.isth.org/abstract/utility-of-platelet-parameters-in-pediatric-outpatient-setting-experience-from-a-single-institution/. Accessed December 3, 2021.
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