Abstract Number: PB1296
Meeting: ISTH 2021 Congress
Background: Guidelines for pregnancy and post-partum thromboprophylaxis are largely expert-based, and differ widely from country to country. We performed a retrospective analysis of a local database with respect to RCOG guidelines to assess the utility in preventing pregnancy-related VTE.
Aims: The aim of the study was to assess the utility in preventing pregnancy-related VTE (PA-VTE).
Methods: A local database was used to identify women who had suffered a PA-VTE, and the notes reviewed to assess their RCOG score. 290 previously pregnant women were identified, and of these 225 had no previous history of VTE. The notes were obtained and a review of risk factors as listed in RCOG were available for 216 cases.
|RCOG Risk Factor Score||No of women with no VTE||No of women with VTE|
|0||17 (61%)||11 (39%)|
|1||45 (66%)||23 (34%)|
|2||46 (79%)||21 (21%)|
|3||39 (32%)||83 (68%)|
|Specific Risk Factor|
|BMI >30||80 (77%)||24 (23%)|
|Age over 35||47 (76%)||15 (24%)|
Results: Those with 4 or more risk factors were analysed in a separate submission; table 1 shows the results of number of risk factors and number of women who did or did not have a PA-VTE. For 3 risk factors, those women who suffered a clot did so prior to 28 weeks. A further stratification focused on the RCOG risk factors “BMI >30”, which showed 23% of cases experienced a PA-VTE, and the RCOG risk factor “Age over 35”, which showed 24% of cases of women aged 35 experienced a PA-VTE.
Conclusions: There was no clear predictive value of the RCOG guidance from this small study, in particular with the factors of maternal age and BMI not demonstrating a clear positive correlation of adverse outcomes in VTE, either antenatally or postnatally.
To cite this abstract in AMA style:Jackson E, Treharne E, Alexander A, Myers B. Utility of Royal College of Obstetricians and Gynaecologists (RCOG) Guidelines in Preventing Pregnancy Related Venous Thrombo-embolism (PA-VTE) [abstract]. Res Pract Thromb Haemost. 2021; 5 (Suppl 2). https://abstracts.isth.org/abstract/utility-of-royal-college-of-obstetricians-and-gynaecologists-rcog-guidelines-in-preventing-pregnancy-related-venous-thrombo-embolism-pa-vte/. Accessed December 3, 2021.
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