ISTH Congress Abstracts

Official abstracts site for the ISTH Congress

MENU 
  • Home
  • Congress Archive
    • ISTH 2022 Congress
    • ISTH 2021 Congress
    • ISTH 2020 Congress
  • Resources
  • Search

Value of Super Microvascular Imaging and Contrast-enhanced Ultrasound in Evaluating the Neovascularization of Synovial Hypertrophy in Hemophilia Joints

Y. Li1, Y. Zhang1, C. Xu1, J. Sun2, Y. Gao1, H. Liu1, M. Fei1

1Nanfang Hospital, Southern Medical University, Department of Medicine Ultrasonics, Guangzhou, China, 2Nanfang Hospital, Southern Medical University, Department of Hematology, Guangzhou, China

Abstract Number: PB1033

Meeting: ISTH 2020 Congress

Theme: Hemophilia and Rare Bleeding Disorders » Hemophilia - Clinical

Background: Joint bleeding occurred in hemophilia patient can stimulate synovial hyperplasia and neoangiogenesis. Our earlier study suggest the evaluation of neovascularization would help predict the possibility of recurrent joint bleeding. Therefore, exploring the general rule for neovascularization in the synovium after joint bleeding may contribute to the therapy for preventing recurrent joint bleeding.

Aims: To find a sensitive tool to evaluate the neovascularization and general rule of neovascularization in the synovium after joint bleeding.

Methods: 29 severe hemophilia A patients with 41 joints underwent gray-scale ultrasound, Color Doppler Flow Imaging (CDFI), SMI and CEUS examinations. Clinical data were collected from routine practice. Semi-quantitative analysis was based on the displaying proportion of blood flow signal in the synovium .Quantitative parameters were used to analyze the progression of neovascularization in synovium at different time points (1W, 2W, 3W, 3W-3 months,> 3 months) after joint bleeding, and the correlation between quantitative parameters and the frequency of joint bleeding in the past six months were also studied.

Results: Compared with semi-quantitative scores of SMI and CDFI, CEUS showed increased scores in 33 and 38 joints selectively. SMI vascular index, CEUS peak intensity (PT), and area under the curve (AUC) all peaked in the third week after joint bleeding. Frequency of joint bleeding in the past six months was positively correlated with SMI vascular index, and PT, (r = 0.408-0.597), P < 0.05, while negatively correlated with TP, (r = -0.421), P < 0.05.

Conclusions: SMI and CEUS seems to be more sensitive than CDFI in evaluating neovascularization of synovial hyperplasia. Besides, the peak value of synovial neovascularization in the third week after joint bleeding correlates positively with the frequency of joint bleeding during the past six months. Therefore, accurate evaluation of the neovascularization and hyperplasia rule in the synovium may be beneficial in guiding targeted and individualized treatment.

To cite this abstract in AMA style:

Li Y, Zhang Y, Xu C, Sun J, Gao Y, Liu H, Fei M. Value of Super Microvascular Imaging and Contrast-enhanced Ultrasound in Evaluating the Neovascularization of Synovial Hypertrophy in Hemophilia Joints [abstract]. Res Pract Thromb Haemost. 2020; 4 (Suppl 1). https://abstracts.isth.org/abstract/value-of-super-microvascular-imaging-and-contrast-enhanced-ultrasound-in-evaluating-the-neovascularization-of-synovial-hypertrophy-in-hemophilia-joints/. Accessed December 10, 2023.

« Back to ISTH 2020 Congress

ISTH Congress Abstracts - https://abstracts.isth.org/abstract/value-of-super-microvascular-imaging-and-contrast-enhanced-ultrasound-in-evaluating-the-neovascularization-of-synovial-hypertrophy-in-hemophilia-joints/

Simple Search

Supported By:

Takeda logo

ISTH 2022 Congress site

Visit the official web site for the ISTH 2022 Virtual Congress ยป

  • Help & Support
  • About Us
  • Cookies & Privacy
  • Wiley Job Network
  • Terms & Conditions
  • Advertisers & Agents
Copyright © 2023 John Wiley & Sons, Inc. All Rights Reserved.
Wiley