Abstract Number: PB2297
Meeting: ISTH 2020 Congress
Background: Vascular involvement is frequent in Behcet disease (BD). Vascular manifestations are more frequently venous than arterial.
Aims: We aimed in this work to describe clinical characteristics, predictive factors and management of venous involvement during BD in the Tunisian context
Methods: We retrospectively studied 281 records of BD patients followed between January 2004 and December 2017 in the Internal Medicine Department and who fulfilled the International Study Group for BD (ISGBD) criteria. We described first clinical features of BD with venous involvement then predictive factors were studied in univariate then multivariate analysis.
Results: Among 281 patients, 61 have had venous involvement. They were 82% males and 18% females with a mean age of 32 years (12 to 55 years). Superficial venous thrombosis were diagnosed in 18 patients (29.5%) associated or not to deep venous thrombosis in 46 cases (75.4%) as follow: upper arm (16.4%), inferior limb (37.7%), inferior vena cava (13.1%), superior vena cava (1.6%) and mesenteric vein (1.6%). Venous involvement was associated to arterial manifestations in 9 patients (14.8%). Treatment consisted in high doses of steroids in 42.6%, cyclophosphamide in 21.3% and anticoagulation in 79.3%. Predictive factors independently associated with venous involvement in BD are male gender (OR=0.3, 95% CI= 0.14-0.67, p=0.004), erythema nodosum(OR= 4.2, 95% CI= 1.7- 10.6, p=0.002), ophthalmic involvement (OR= 0.46, 95% CI= 0.24- 0.9, p=0.024) and orchi epididymitis (OR= 4.8, 95% CI= 1.42 -16.38, p= 0.012).
Conclusions: Venous involvement in BD is frequent in the Tunisian context consisting in deep and superficial veins. Male gender, patients with erythema nodosum, ophthalmic manifestations or orchi epididymitis are more prone to develop venous complications needing therefore a close monitoring. In addition to anticoagulant, treatment should associate steroids and immunosuppressors.
To cite this abstract in AMA style:Kechida M, Fraj A, Daada S, Klii R, Hammami S, Khochtali I, Sassi M. Venous Involvement in Behcet Disease: Clinical Spectrum and Predictive Factors [abstract]. Res Pract Thromb Haemost. 2020; 4 (Suppl 1). https://abstracts.isth.org/abstract/venous-involvement-in-behcet-disease-clinical-spectrum-and-predictive-factors/. Accessed May 16, 2022.
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