Abstract Number: OC 25.3
Meeting: ISTH 2022 Congress
Background: Knowledge of sex differences in venous thromboembolism (VTE) among cancer patients is limited.
Aims: To determine age- and sex-specific incidence of first-time VTE in patients with a diagnosis of cancer, and to study differences in prevalence of different cancers between men and women with a first time-VTE.
Methods: Nationwide Swedish registry-based case-control study including all patients with first-time venous thromboembolism (VTE) 1987-2018 and controls free of VTE, matched for age, sex, and county of residence. Incidence was determined by dividing number of patients with VTE and cancer, by the Swedish population in the same age group for each year. Odds ratios (OR) for a diagnosis of cancer (within 7 years of VTE diagnosis) was compared to matched controls, using conditional logistic regression, adjusting for multiple comorbidities.
Results: A total of 63,477 first time VTE patients had a prior or concomitant diagnosis of cancer. On a population level, incidence of VTE in patients with cancer was 22.0 per 100 000 for men and 23.0 per 100 000 for women. The incidence was higher in men compared to women after 64 years of age, Figure 1. When compared with matched controls, women with VTE had slightly higher odds ratio for malignancy than men, multivariable adjusted OR:2.85 (99% CI 2.78-2.91) vs 2.56 (2.50-2.62). Cancers with the highest OR were pancreatic cancer, liver, gallbladder and bile duct cancer and lung cancer, with no significant sex difference see Table 1.
Conclusion(s): Incidence rate of VTE in patients with a diagnosis of cancer was higher in men compared to women on a population level. The odds ratio of a diagnosis of cancer was slightly higher in women compared to men in patients with VTE compared to matched controls without VTE.
To cite this abstract in AMA style:Glise Sandblad K, Sörbo J, Karlsson P, Rosengren A, Hansson P. Venous thromboembolism and cancer. Incidence and sex difference. [abstract]. https://abstracts.isth.org/abstract/venous-thromboembolism-and-cancer-incidence-and-sex-difference/. Accessed September 22, 2023.
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