Abstract Number: PB0171
Meeting: ISTH 2021 Congress
Background: Venous Thromboembolism has been observed as a frequent complication in patients with severe COVID-19 infection requiring hospital admission.
Aims: To evaluate the epidemiology of venous thromboembolisms in hospitalized intensive care (ICU) and non-ICU patients.
Methods: PubMed was searched up to 13th of Nov 2020 and updated in December 12th, 2020. We included studies that evaluated the epidemiology of VTE, including PE and/or DVT, in patients with COVID-19. See Figure 1.
Results: A total of 91 studies reporting on 35,017 patients with COVID were included. The overall frequency of VTE in all patients, ICU and non-ICU was 12.8% (95% CI 11.103 to 14.605), 24.1% (95% CI 20.070 to 28.280), and 7.7% (95% CI 5.956 to 9.700), respectively. PE occurred in 8.5% (95% CI 6.911 to 10.208), and proximal DVT occurred in 8.2% (95% CI 6.675 to 9.874) of all hospitalized patients. The relative risk for VTE associated with ICU admission was 2.99 (95% CI 2.301 to 3.887, P value <0.001). DVT and PE estimates in studies that adopted some form of systematic screening were higher compared to studies with symptom-triggered screening. Analysis restricted to studies in the 5th quintile of sample size reported significantly lower VTE estimates.
|patient category||number of patients||patient with VTE(%)||95% Confidence Interval|
|All Patients||35017||12.827||11.117 to 14.641|
|ICU Patient||8719||24.055||20.070 to 28.280|
|Non-ICU||12941||7.724||5.956 to 9.700|
Conclusions: This study confirmed a high risk of VTE in hospitalized COVID-19 patients specially those admitted to the ICU. Nevertheless, sensitivity analysis suggests that previously reported frequencies of VTE in COVID-19 might have been overestimated.
To cite this abstract in AMA style:Mansory E, Srigunapalan S, Lazolangner A. Venous Thromboembolism in Hospitalized Critical and Non-critical COVID-19 Patients: A Systematic Review and Meta-analysis [abstract]. Res Pract Thromb Haemost. 2021; 5 (Suppl 2). https://abstracts.isth.org/abstract/venous-thromboembolism-in-hospitalized-critical-and-non-critical-covid-19-patients-a-systematic-review-and-meta-analysis/. Accessed June 25, 2022.
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