Abstract Number: PB1294
Meeting: ISTH 2020 Congress
Background: VTE associated with CA-SAB in previously healthy children is increasingly recognized. Inherited and acquired prothrombotic risk factors in this setting have been scarcely investigated.
Aims: To identify risk factors associated with VTE in a cohort of children with CA-SAB at a single pediatric tertiary care center and to assess its prevalence. To describe clinical characteristics, laboratory findings and outcomes of the cohort with VTE.
Methods: From January-2013 to December-2019 consecutive previously healthy children< 18 years admitted with CA-SAB were registered by epidemiological surveillance study in our hospital and patients with confirmed VTE were prospectively recruited. From January-2018 to December-2019, patients with CA-SAB without VTE were also included for laboratory testing(LT). Clinical and laboratory risk factors from both cohorts were statistically analyzed.(STATA 12.0). Level of significance: 0.05.
Results: During a seven-year period, 334 children with CA-SAB were admitted, VTE was confirmed in 39 of them. VTE prevalence was 11.5% (CI 95% 8.2.-15.3). Figure1 describes clinical characteristics and outcomes of VTE patients.
LT was consented in 28/89 recruited patients of the cohort with CA-SAB without VTE. No statistical differences in clinical variables were observed between the 28patients available for LT and the remaining 61patients. Figure2 summarizes univariate analysis of risk factors in patients with and without VTE.
Conclusions: This is the largest prospective pediatric cohort assessing VTE in the setting of CA-SAB. VTE prevalence was similar to published data.
In this study, older children, severe infection, pulmonary infection and a longer hospital stay were associated with significant higher risk of developing VTE. No association with either acquired or hereditary thrombophilia was found.
A very low frequency of catheter-related thrombosis was observed and there was neither thrombosis recurrence nor VTE-related death. In this setting, most of the VTE were adjacent to infected foci; these findings suggest physiopathological mechanisms of thrombosis which are yet to be elucidated.
To cite this abstract in AMA style:Cervio C, Hepner M, Annetta E, Pieroni G, Bianco MB, Frontroth JP, Smigliani A, Perez MG, Ruvinsky S, Sciuccati G. Venous Thromboembolism (VTE) in Children with Community-acquired Staphylococcus Aureus Bacteremia (CA-SAB) in Children: Risk Factors and Prevalence Study from a Single Pediatric Tertiary Care Center in Argentina [abstract]. Res Pract Thromb Haemost. 2020; 4 (Suppl 1). https://abstracts.isth.org/abstract/venous-thromboembolism-vte-in-children-with-community-acquired-staphylococcus-aureus-bacteremia-ca-sab-in-children-risk-factors-and-prevalence-study-from-a-single-pediatric-tertiary-care-center-i/. Accessed December 5, 2021.
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