Background: Warfarin toxicity is an increasing concern globally. Accidental and intentional poisonings is a significant source of morbidity, mortality, and health care expenditure around the world. Unfortunately, limited literature on toxicological data in Pakistan available. Information about acute poisoning is essential for the prevention and management.
Aims: Evaluation of Acute Poisoning cases in the emergency department (ED) of a tertiary care hospital in Karachi, Pakistan.
Methods: Retrospectively medical records were reviewed of patients presenting with acute poisoning in ED between 2011 to 2016. Total 892 cases of various acute poisoning due to drugs and chemicals in people of all ages were reviewed. Data regarding age, sex, name of poisonous substances, and outcome were reviewed. Poisons involved were classified into 3 categories: pharmaceuticals agents, pesticides (organophosphorus agents) and also non medicinal substances (food poisoning).
Results: Based on data review, total 892 patients presented with acute poisoning in which 512(57.39%) patients were female and adults were 614 (68.83%). A majority of the poisoning cases were due to miscellaneous drug overdose. Total drug overdose patients were 405 in which adults were 363(89.62%). Warfarin toxicity cases presented in total 217 patients in which geriatrics were 131(60.36%). Organophosphorus poisoning cases were 26 in which adult were 25(96.15%). 53 cases presented with Food poisoning in which 34 (64.15%) were peads.
Conclusions: These up-to-date data provide us important information which serve as a baseline to make a guidelines to improve activities such as professional trainings, preventive measures, community education and new research across Pakistan. Warfarin finding is very significant and it gives us clue to work on this important toxicity which is a neglected area of concern in developing country.
Keyword: Warfarin, a Real threat, Acute poisoning, Emergency department (ED), Tertiary care hospital, Patient outcome.
To cite this abstract in AMA style:Perveen F, Mairaj M. Warfarin – A Real Threat in Evaluation of Acute Poisoning in the Emergency Department (ED) of a Tertiary Care Hospital – A Base Line Study to Make a Strategy for Better Patient Outcome [abstract]. Res Pract Thromb Haemost. 2020; 4 (Suppl 1). https://abstracts.isth.org/abstract/warfarin-a-real-threat-in-evaluation-of-acute-poisoning-in-the-emergency-department-ed-of-a-tertiary-care-hospital-a-base-line-study-to-make-a-strategy-for-better-patient-outcome/. Accessed January 27, 2022.
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ISTH Congress Abstracts - https://abstracts.isth.org/abstract/warfarin-a-real-threat-in-evaluation-of-acute-poisoning-in-the-emergency-department-ed-of-a-tertiary-care-hospital-a-base-line-study-to-make-a-strategy-for-better-patient-outcome/