Background: Venous thromboembolic disease is a multifactorial disease. The incidence varies across continents, lower in Asia, compared to Europe. Reunion Island was an uninhabited island, which became French in 1638, with different waves of population arrivals, of various origins (Malagasy, African and Indian) with a lot of interbreeding.

Aims: To analyse the differents factors of thrombophilia in Reunion Island, and compare to Europe and Asian.

Methods: We performed a retrospective study, from 2005 to 2018, in an Angiology department in Saint-Paul, including all patients who have a personal history of venous thrombosis (VT) or who are part of a family survey, with a complete thrombophilia screening, and, we have a retrospective study of thrombophilia for differents pathologies, in hospital in Saint-Denis in 2018-2019.

Results: 48 patients were included, 42 following a VT( calf, proximal, pulmonary embolism, 1 cerebral, 2 superficial) and 6 in a family survey. 31 patients have Reunion origin and 17 Metropolitan origin. For thrombophilic factors, we find 1 mutation of Factor II G20210A heterozygous (FII), 15 inhibitor deficiency, and 13 mutations of V Leiden heterozygote (FVL) in Reunion patients and 3 mutations (FII), 4 of inhibitor deficiency, and 6 (FVL) in metropolitan patients, for the first. In the second, we have 239 research of FII and 6 were positive ( 2 not after VT) and 934 research of inhibitors deficiency and 134 were positive.

Conclusions: If we compare the incidences of the different thrombophilia of Reunion Islanders with other populations, we find a similar frequency of inhibitors deficiency as in the Asian population and similar frequency of FVL like caucasian. On the other hand, we find few FII, only heterozygous. Maybe, this mutation is not in relation with thrombosis like in Asian country, and the mutation of Arg596 could be present, like many others that have been identified in Asian.

[Comparison of percentage and prevalence of thrombophilia in Reunion Island and in different ethnicity]

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