Abstract Number: PB1026
Meeting: ISTH 2022 Congress
Background: ¬Current prehospital haemostatic resuscitation is largely based on platelet-poor blood components, e.g. red cells and plasma (RCP). Clinical trials have demonstrated improved outcomes compared to crystalloid resuscitation but the effect of these components and whole blood (WB) on trauma-induced coagulopathy (TIC) have not been fully characterised.
Aims: Compare the ability of WB versus RCP to correct ex vivo platelet-related haemostatic parameters in patients with TIC.
Methods: Samples were collected from trauma patients who activated the major haemorrhage protocol prehospital and were enrolled into a prospective cohort study (ISRCTN12962642) at a UK major trauma center in 2021/2022. Each sample was aliquoted and spiked ex vivo with a volume of RCP or WB equivalent to four units. ROTEM EXTEM and FIBTEM were performed on non-spiked and spiked samples. Platelet count was measured using flow cytometry, while aggregation and agglutination with multiple electrode aggregometry. The original components and healthy-donor samples were assayed as controls (REC 07/Q702/24). RCP and WB were stored at 4°C up to two weeks.
Results: Samples from 19 adult trauma patients and 5 healthy donors were analysed. Patients’ median age was 31 years, 89% were male, TIC was present in 68% (EXTEM A5
Conclusion(s): When compared to RCP ex vivo, WB preserves or improves most platelet-related haemostatic parameters.
To cite this abstract in AMA style:Rossetto A, Vulliamy P, Green L, Davenport R. Whole blood better supports platelet measures of haemostasis compared to red cells and plasma: an ex vivo spiking study [abstract]. https://abstracts.isth.org/abstract/whole-blood-better-supports-platelet-measures-of-haemostasis-compared-to-red-cells-and-plasma-an-ex-vivo-spiking-study/. Accessed October 1, 2023.
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