Abstract Number: PB2555
Meeting: ISTH 2020 Congress
Background: Pharmacological thromboprophylaxis is commonly recommended for the prevention of postpartum venous thromboembolism.1 The proportion of women who experience minor bleeding and other adverse events has not been well-characterized.
Aims: Describe women´s experience of minor bleeding and other adverse events in the postpartum period and compare self-reported events among those who did and did not receive postpartum pharmacological thromboprophylaxis.
Methods: A prospective cohort study was undertaken at the Rotunda Hospital, Dublin. Using convenience sampling, a paper-based questionnaire was distributed to postpartum women. Women were asked about minor bleeding and other adverse effects which occurred since childbirth. All women were followed up by telephone to ascertain minor bleeding and adverse events during the first 6 weeks after discharge. Data were analysed using descriptive statistics and multivariable logistic regression.
Results: In total, 479 women completed the questionnaire during their postpartum admission (Table 1). Over 40% reported a minor bleeding or adverse event since childbirth (n=202, 42.2%). The most frequently reported events were bruising, gingival bleeding and skin rash (Table 2). Of the 320 women who completed the follow-up questionnaire, one in three reported a minor bleeding event or adverse event in the six weeks since discharge from hospital (n=107, 33.4%).
Women who received postpartum thromboprophylaxis had increased odds of minor bleeding events and adverse events during their postpartum admission, compared with those who did not receive pharmacological thromboprophylaxis (OR 2.2, 95%CI:1.5-3.2, P< 0.01 and OR 3.1, 95%CI:1.8-5.4, P < 0.01, respectively). However, when adjusted for underlying population-level differences, only self-reported minor bleeding remained significant (aOR 1.8, 95%CI 1.0-3.2, P 0.04). Similarly, no difference in the odds of self-reported minor bleeding or adverse events was observed in the first six weeks after discharge among those who received postpartum thromboprophylaxis (Table 2).
Conclusions: Women commonly report minor bleeding and other adverse effects in the postpartum period.
To cite this abstract in AMA style:Donnelly M, O'Shaughnessy F, McElligott G, Murphy S, O'higgins A, Ryan G, Tierney A, Mulvagh A, Bennett K, Ni Ainle F, Donnelly J, Brian C. Women’s Experience of Bleeding and Adverse Events Associated with Postpartum Pharmacological Thromboprophylaxis: A Prospective Cohort Study [abstract]. Res Pract Thromb Haemost. 2020; 4 (Suppl 1). https://abstracts.isth.org/abstract/womens-experience-of-bleeding-and-adverse-events-associated-with-postpartum-pharmacological-thromboprophylaxis-a-prospective-cohort-study/. Accessed December 6, 2021.
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