Abstract Number: PB0528
Meeting: ISTH 2020 Congress
Background: Ph-negative myeloproliferative neoplasms (MPN) such as polycythemia vera (PV), essential thrombocythemia (ET) and primary myelofibrosis (PMF) are characterized by thrombotic complications. Currently there is not general diagnostic laboratory method for the development of thrombosis. Disorders in the system of fibrinolysis are one of the factors that contribute to the progress of thrombosis. The time of XIIa-dependent fibrinolysis can extend with these patients and represent a change of the balance between blood coagulation and fibrinolysis.
Aims: Aim of this study to estimate time of XIIa-dependent fibrinolysis in patients with Ph-negative myeloproliferative neoplasms.
Methods: The study involved 73 patients with MPN (28 with PV, 17 with ET and 28 with PMF) and 38 healthy controls. XIIa-dependent fibrinolysis (minutes) was tested by “renam” (Russia). STATISTICA 12.0 was used. The results are given as median (Me) with 95% confidence intervals (CI). Mann-Whitney test was used to compare the studied groups. P< 0.05 was considered statistically significant.
Results: The data are shown in the table (*-p< 0.05 compare to controls,**-p< 0.05 differences between PV and PMF, ***-p< 0.05 differences between ET and PMF).
XIIa-dependent fibrinolysis is significantly higher in the whole group of patients with MPN and PMF. The most expressed changes in fibrinolysis (prolongation of time XIIa-dependent fibrinolysis) are identified in patients with PMF, while this parameter in patients with PV and ET is not differ from the control but it has a tendency to both decrease and increase. This fact can be considered as a sign of disbalance of coagulation in patients with Ph-negative myeloproliferative neoplasms and require further study.
Conclusions: In patients with PMF are detected significant prolongation of time of XIIa-dependent fibrinolysis. These changes indicate inhibition of fibrinolysis. Fibrinolytic system disfunction can lead to imbalance in hemostatic system with prothrombotic states development in MPN.
|Parameter||MPN (n=73)||PV (n=28)||ET (n=17)||PMF (n=28)||Controls (n=40)|
|XIIa-dependent fibrinolysis, min||6.25* 3.75-20.00||6.17** 3.25-10.22||6.08*** 3.95-12.25||10.67* 5.33-29.83||5.29 4.16-7.33|
[XIIa-dependent fibrinolysis in patients with MPN (Ме; 95% CI)]
To cite this abstract in AMA style:Silina N, Korsakova N, Golovina O, Matvienko O, Efremova E, Fominykh M, Shuvaev V, Voloshin S, Papayan L. XIIa-Dependent Fibrinolysis in Patients with Ph-Negative Myeloproliferative Neoplasms (MPN) [abstract]. Res Pract Thromb Haemost. 2020; 4 (Suppl 1). https://abstracts.isth.org/abstract/xiia-dependent-fibrinolysis-in-patients-with-ph-negative-myeloproliferative-neoplasms-mpn/. Accessed September 22, 2023.
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