ISTH 2020 Congress Archives - ISTH Congress Abstracts

Abstract Number: PB1186

A Bypass Surgery with Congenital Factor 5 and Factor 8 Deficiency

V. Okan, H.H. Şahin, D.M. Akkurd
Abstract Number: PB0905

A Canadian, Multi-Center, Retrospective, Non-Interventional Study of Clinical Outcomes from Early Use of N9-GP Compared with Previous Treatment in Patients with Hemophilia B in a Real-World Setting

D. Matino¹, A. Iorio¹, A. Keepanasseril¹, F. Germini², A.C. Birkegård³, A. Caillaud⁴, M. Carcao⁵, J. Hews-Girard⁶, E. Iserman⁷, P. James⁸, A. Lee⁹, C. Phua¹⁰, H. Sun¹¹, J. Teitel¹², M.-C. Poon¹³
Abstract Number: PB0008

A Case Report of a Patient with Hereditary Angioedema and Samter´s Syndrome Treated with Anticoagulant of Direct Action Anti Xa (Rivaroxaban), Secondary to Angioplasty due to Ischemic Heart Disease

B.S. Zuñiga Ascencio^1,2, F. Vidal Martinez³, M. Castillejos López⁴, B.A. Lira Mendoza⁵, M.E. Jaime Capetillo⁵, E. Juárez Silva⁵, R. Guevara Gutiérrez⁵
Abstract Number: PB2454

A Case Report of Deep Vein Thrombosis after Kidney Transplantation

I. Puspitawati¹, I. Kuswadi², Y. Wardhani², T. Widodo³
Abstract Number: PB0711

A Case Report of Spontaneous and Recurrent Arterial and Venous Thrombotic Events in a Child with FGA c.1372C>T Mutation

H. Yixuan, W. Runhui, Z. Rui, Y. Jiafeng
Abstract Number: PB1432

A Challenging Case of Delayed-onset Refractory Heparin-induced Thrombocytopenia Complicated with Arterial Thrombosis

S. Van de Vondel
Abstract Number: PB1305

A Child with Ischemia of the Glans Penis after Circumcision

L.D. Rahmartani¹, G.R. Situmorang², T.T. Sari¹, I. Wahyudi²
Abstract Number: PB1609

A Close Relationship between Adipocytes and Megakaryocytes

C. Valet, A. Batut, A. Vauclard, A. Dortignac, M. Bellio, B. Payrastre, P. Valet, S. Severin
Abstract Number: PB2283

A Combination of Age Adjusted Cut-Off and Preanalytical Conditions Monitoring for Increased DDIM Assay Specificity

J. Prochazkova, L. Slavik, J. Ulehlova, J. Kaminkova, P. Chalupnikova, V. Krcova, A. Hlusi
Abstract Number: PB0856

A Comparative Analysis of the Immune Response to Homologous Coagulation Factors V and VIII

M.L. Sauer¹, A.R. Wilhelm¹, R.J. Davidson¹, L.A. George^1,2, R.M. Camire^2,3
Abstract Number: PB0201

A Comparison of Mass and Potency Equated Bovine and Porcine Heparins

S. Krishnappan, F. Siddiqui, A. Farooqui, O. Iqbal, A. Kouta, D. Hoppensteadt, W. Jeske, J. Walenga, J. Fareed
Abstract Number: PB0670

A Correlation of Thrombin Generation Assay and Clot Waveform Analysis in Patients on Warfarin

M.A. Cheong, C.W. Tan, W.H. Wong, M.C. Kong, E. See, S.H. Yeang, S.K. Koh, Y.T. Shim, L.H. Lee, H.J. Ng
Abstract Number: PB0248

A Critical Role of Carboxyl-Terminal Alpha-Helix in the Secretion of Coagulation Factor XI

Y. Hayakawa¹, S. Tamura¹, N. Suzuki², K. Odaira¹, M. Tokoro¹, F. Kawashima¹, F. Hayakawa¹, A. Takagi¹, A. Suzuki³, S. Okamoto⁴, T. Kanematsu³, T. Matsushita^2,3, T. Kojima^1,5
Abstract Number: PB2335

A Decade of Experience in Peripherally Inserted Central Catheter (PICC) Related Thrombosis in Hematological Malignancies of a Single Spanish Center

E. Sobejano¹, M. Fonseca¹, M. Baile¹, M. Vaquero², B. Rey¹, V. Higuero¹, M. Sastre¹, O. del Rey¹, B. Perez¹, M. de la Iglesia¹, H. Sanchez¹, R. Garcia¹, I. Rodriguez¹, D. Sanchez¹, J.R. Gonzalez Porras¹, J.M. Bastida¹
Abstract Number: PB1075

A Descriptive Study of Physical Activity and Fitness Level Profiles of Nigerians with Haemophila

H. Okoye¹, T. Nwagha¹, N. Chigbo², E. Anekwu³
Abstract Number: PB1196

A Digestive Hemorrhage Like No Other

Y. Cherif, S. Hamrouni, M. Mrouki, S. Derbel, F. Ben Dahmen, M. Abdallah
Abstract Number: PB0189

A Double Heterozygous Factor VII (FVII) Deficiency: Exon 9 Missense Mutation (Arg364Gln – FVII Padua) and a Novel Exon 3 Missense Mutation (Ala87Gly)

C. Gallardo¹, C.L.L. Sum¹, L.J.L. Wong¹, K.H. Ong¹, L.L. Goh²
Abstract Number: PB0889

A French Multicentre Prospective, Non-Interventional Study (B-SURE) Evaluating Real-World Usage and Effectiveness of Recombinant Factor IX Fc Fusion Protein (rFIXFc) in People with Haemophilia B: Baseline Data

H. Chambost¹, B. Wibaut², A. Borel Derlon³, S. Claeyssens⁴, S. Castet⁵, R. d'Oiron^6,7, C. Negrier⁸, H. Andersson⁹, S. Bergenstråle⁹, C. Gandossi¹⁰, C. Martinez¹⁰
Abstract Number: PB0859

A Generic Recombinant Factor VIIa Is Comparable to the Branded Novoseven in In-vitro and Pharmacokinetic Studies in Primates

M. Iacobelli¹, N. Sadeghi¹, A. Kouta¹, R. Duff², O. Iqbal¹, D. Hoppensteadt¹, W. Jeske¹, J. Walenga¹, J. Fareed¹
Abstract Number: PB0732

A Genetic Modifier of Venous Thrombosis in Zebrafish Reveals a Functional Role for Fibrinogen AαE in Early Hemostasis

R.J. Fish¹, C. Freire¹, R. Vilar², C. Di Sanza¹, S.J. Grzegorski³, C.E. Richter⁴, J.A. Shavit³, M. Neerman-Arbez¹
Abstract Number: PB0393

A Hereditary Bleeding Disorder Caused by a Novel Homozygous Mutation of Thrombomodulin Gene

M. Osada¹, K. Maruyama², K. Kokame², R. Denda¹, K. Yamazaki¹, H. Kunieda¹, M. Hirao¹, S. Madoiwa³, N. Okumura⁴, M. Murata⁵, Y. Ikeda⁶, Y. Tsukada¹, T. Kikuchi¹
Abstract Number: PB1731

A Humanised CLEC-2 Mouse Model to Study Anti-Human CLEC-2 Biologics in vivo

H. Brown¹, S. Navarro¹, Y. Di², S. Thomas², S. Watson², B. Nieswandt¹, D. Stegner¹
Abstract Number: PB1365

A Long Term Survival Chronic DIC with ITP Treated with Low Dose Steroid

Y. Seki, O. Nagano
Abstract Number: PB/CO05

A Low Dose Heparin Protocol Is Associated with Improved Duration of Arterial Line Patency in Critically Ill COVID-19 Patients

L. Maurer¹, C. Luckhurst¹, A. Hamidi², K. Newman², M. Barra², M. El Hechi³, A. Mokhtari³, K. Breen³, L. Lux⁴, L. Prout⁴, J. Lee^3,5, E. Bittner⁶, D. Chang^1,7, H. Kaafarani³, R. Roberts², R. Rosovsky⁸
Abstract Number: PB0414

A Membrane-Adjacent Region in Tissue Factor Provides Substrate Selectivity

F. Birkle¹, J.H. Morrissey^1,2
Abstract Number: PB1229

A Multi Centre Non-randomised Clinical Trial to Establish the Efficacy of Peer Reviewed Physiotherapy Treatment Protocols among PWH in India

P. Narayan
Abstract Number: PB0295

A Multicenter Experience with Idarucizumab “In Real World” as Reversal Anticoagulation of Dabigatran

I. Amarilla Lanzas¹, N. Fernández Mosteirín², J.M. Calvo Viñas², L.I. Sancho Val³, I. Cuesta Gallardo⁴, O. Gavín Sebastián³
Abstract Number: PB1034

A Multicenter Open-label Single Arm Trial to Evaluate Safety and Efficacy and Pharmacokinetics of Recombinant Human Coagulation Factor VIII (SCT800) in Previously Treated Patients with Severe Hemophilia A under Prophylaxis Therapy

W. Liu¹, X. Zhao², F. Xue¹, J. Sun³, X. Zeng⁴, F. Yang⁵, Z. Yu⁶, M. Xu⁷, W. Li⁸, W. Gu⁹, Y. Feng¹⁰, C. Zheng¹¹, H. Bi¹², R. Yang¹
Abstract Number: PB0802

A Multicenter Prospective Validation Study on Disseminated Intravascular Coagulation in Trauma-Induced Coagulopathy

S. Gando¹, A. Shiraishi², T. Wada³, K. Yamakawa⁴, T. Mayumi⁵, Y. Otomo⁶, JAAM Forecast
Abstract Number: PB0799

A New Classification of Sepsis-Associated Disseminated Intravascular Coagulation (DIC) Based on Comprehensive Evaluation of Coagulation and Fibrinolysis

T. Onishi¹, K. Nogami¹, T. Ishihara¹, S. Inoue², M. Kawaguchi², K. Nishio³, H. Fukushima⁴, H. Kobayashi⁵, I. Amano⁶, T. Nishikubo⁷, M. Yamasaki⁸, M. Kasahara⁹, M. Shima¹
Abstract Number: PB0735

A New Genetic Alteration in Fibrinogen Gene with a Direful Phenotype: A Tie-in in a Newborn

T. Nafees, Bleeding Disorder Working Group
Abstract Number: PB2229

A New Global Assay for Detection of Protein C Pathway-Associated Thrombophilia Using Thrombomodulin-Mediated Clot Waveform Analysis

N. Hashimoto, K. Ogiwara, K. Nogami, M. Shima
Abstract Number: PB0326

A New Test Set up to Dose Factor VIII Ability to Bind Exogenous VWF

F. Mori¹, C. Genuardo¹, A. Caricasole¹, M. Grimaux², O. Kerleau², O. Mathieu², S. Natelli², T. Hervé³, F. Depasse³, P. Fuligni⁴, A. Juif⁵
Abstract Number: PB2136

A Newly Developed Kit for High-Sensitivity Measurement of TF-Dependent Procoagulant Activity on Microvesicles Purified by High-Speed Centrifugation

T. Bouriche¹, C. Judicone¹, C. Franco¹, L. Vallier², V. Cucini³, O. Mathieu², F. Dignat-George⁴, R. Lacroix⁴, P. Poncelet¹
Abstract Number: PB1144

A Next Generation Recombinant Factor VIII for Subcutaneous Hemophilia A Prophylaxis

P. Herbener¹, J. Schüttrumpf², J. Daufenbach¹, S. Kistner¹
Abstract Number: PB2301

A Non-invasive Diagnostic Work-up Is Safe and Efficient to Exclude Pulmonary Embolism in Low Risk Pregnant Women with Suspected Pulmonary Embolism: A Systematic Review and Meta-analysis

M. Stals¹, T. Moumneh², D. Aujesky³, L. Bertoletti⁴, I. Bistervels⁵, F. Couturaud⁶, A. Elias⁷, G. Le Gal⁶, M.V. Huisman⁸, A.T.A. Mairuhu⁹, S. Middeldorp⁵, L.M. van der Pol⁸, M. Righini¹⁰, H. Robert-Ebadi¹⁰, P.-M. Roy², O. Sanchez¹¹, M. van Smeden⁸, J. Schmidt¹², C. Tromeur⁶, F.A. Klok⁸, on behalf of the CT-PE-Pregnancy Group and Artemis Investigators
Abstract Number: LB/CO01.1

A Novel Adeno Associated Virus (AAV) Gene Therapy (FLT180a) Achieves Normal FIX Activity Levels in Severe Hemophilia B (HB) Patients (B-AMAZE Study)

P. Chowdary^1,2, S. Shapiro³, M. Makris⁴, G. Evans⁵, S. Boyce⁶, K. Talks⁷, G. Dolan⁸, U. Reiss⁹, M. Phillips¹, A. Riddell¹, M.R. Peralta¹, M. Quaye², E. Tuddenham¹, J. Krop¹⁰, G. Short¹¹, S. Kar¹¹, A. Smith¹¹, A. Nathwani^1,2
Abstract Number: PB0223

A Novel Coagulation Factor VIII with Reduced Immunogenicity

K. Winterling¹, W. Martin², A.S. De Groot², J. Daufenbach¹, J. Schüttrumpf³, S. Kistner¹
Abstract Number: OC 05.2

A Novel Contact Pathway Inhibitor Improves Hemostasis and Maintains Circuit Patency in a Piglet Model of Pediatric ECMO

C. Reed¹, D. Bonadonna², G. McDaniel³, J. Otto¹, J. Frederiksen¹, C. Chabata^1,4, B. Sullenger¹, E. Tracy¹
Abstract Number: PB1147

A Novel FVIIIa-Mimetic Bispecific Antibody, Mim8, Enhances FIXa Proteolytic Activity While Allowing for Efficient, Lipid-Dependent Assembly with FX

J. Lund, H. Østergaard, P.J. Greisen, A.C. Bonde, P.S. Gandhi, N. Lorenzen, E. Johansson, L.M. Andersen, M.G. Rasch, S. Lund, R. Zhou, J.R. Bjelke, G. Røder, L.B. Johnsen, F. Stavenuiter, T. Egebjerg, A. Henriksen, B.G. Hansen, K. Thorn, I. Hilden
Abstract Number: PB1097

A Novel Human Factor VIII Variant Exhibits Increased Factor VIII Expression after AAV Gene Therapy in a Unique Hemophilia A Dog Model that is Tolerant to Human Factor VIII

G. Nguyen¹, E. Merricks², T. Long², K. Ponder³, T. Nichols², D. Sabatino^1,4
Abstract Number: PB1599

A Novel Image-Based Chemical-Genetics Screen Identifies Inducers of Platelet Release from Immortalized Megakaryocytic Cell Lines, Enabling Clinical-Scale Production of Functional Platelets

A. Bhan¹, N. Kareddy², E. Forde², G. Merrill-Skoloff³, B. Furie³, A. Frelinger², G. Daley¹, T. Schlaeger¹
Abstract Number: PB0410

A novel Interaction between Coagulation Factor XI and its Activated Form, FXIa, with the Complement Protein Properdin

S.L. Heal¹, L.J. Hardy¹, C. Wilson¹, M. Ali¹, R. Ariëns¹, R. Foster², H. Philippou¹
Abstract Number: PB1677

A Novel Methodology to Study αIIbβ3 Interactions with Polymerizing Cross-linked Fibrin

C. Buitrago, B. Coller
Abstract Number: PB1434

A Novel Missense Mutations of the WASp Gene Cause a Familial X-linked Thrombocytopenia

H. Liu¹, J. Ma¹, R. Wu²
Abstract Number: OC 14.1

A Novel Neutrophil Extracellular Traps (NETs) Assay Predicts DIC and Stratifies Patients with Sepsis for Anti-IL-8 Therapy

S. Abrams¹, B. Morton^2,3, Y. Alhamdi¹, M. Alsabani¹, Z. Cheng^1,4, S. Lane⁵, I. Welters^6,7, G. Wang¹, C.-H. Toh^1,8
Abstract Number: PB0641

A Novel Point-of-Care Whole Blood Coagulation Assay to Screen for Hemostatic Defects

S. Pourang¹, M. Suster¹, D. Maji¹, S. Butala², J. Nutt¹, L. Nayak^1,3, P. Mohseni¹, S. Ahuja^1,2
Abstract Number: PB0169

A Novel Prediction Platform to Enhance the Design of Therapeutic SERPINs

W. Sanrattana¹, S. Smits¹, D. Monroe², C. Maas¹, S. de Maat¹
Abstract Number: PB0660

A Novel Quantitative Chromogenic Fibrinogen Assay Adaptable to Centralized Laboratory Analyzers

S. Pun¹, N. Nienhold¹, A. Ritschl¹, M. Janssen¹, A. Casini²
Abstract Number: PB0158

A Novel Rare C. – 39C>T Mutation in the PROS1 5’UTR Causes Protein S Deficiency by Creating a New Upstream Translation Initiation Codon and an Overlapping Open Reading frame

B. Jaspard-Vinassa¹, C. Proust^2,3, O. Soukarieh^2,3, C. Mouton⁴, Y. Huguelin⁴, M. Roux⁵, J. Constans⁶, A. Boland⁷, R. Olaso⁷, J.-F. Deleuze⁷, P.-E. Morange⁸, S. Labrouche-Colomer^1,4, D.-A. Trégouët^2,3, GENMED Consortium
Abstract Number: PB1669

A Novel Reporter Mouse Line Enables in vivo Imaging of Intracellular Calcium Fluxes in Platelets

V. Klaus¹, C. Gross¹, S. Beck^1,2, D. Stegner^1,2
Abstract Number: PB0793

A Novel Therapeutic Approach for Acute Thrombo-hemorrhagic Disorders Evoked by Snake Venom: Potential of Rutin and Rutin Succinate

A.T.A. Sachetto¹, A.O. de Souza², M.L. Santoro¹
Abstract Number: PB1220

A Nurse Led Service Providing Safe and Effective Peri-Operative Anticoagulation

P. Priest, A. Kadam, L. Moghaddam, N. Kashani, A. Drebes, P. Morjaria, S. Bates
Abstract Number: PB0608

A Performance Evaluation of Chemiluminescent-Enzyme Immunoassays on a Routine Coagulation Analyser

C. Gardiner¹, P. Lane¹, H. Tailor², S.J. Machin¹, I.J. Mackie¹
Abstract Number: PB1806

A Potential Role for the FcγRIIa in Vinorelbine Induced Thrombocytopenia and Neutropenia

J.K. Au Yong¹, Y. Parpia², K. Golla³, J. Ni Gabhann⁴, L. Arkins⁵, D. Cox⁴, M. Brennan⁴
Abstract Number: PB2274

A Practical Comparison of a PE Diagnostic Approach: Is All Wells in the World?

L. Gerstein, M. Koolian, B. Schwartz
Abstract Number: PB2357

A Prospective Observational Multicentre Study to Assess the Incidence of and Risk Factors for (T) Thrombosis (I) in Patients with (L) Lower (L) Limb (I) Injuries (R) Requiring (I) Immobilisation in Ireland (TILLIRI)

D. O'Keeffe¹, F. Ni Ainle², T. Breslin², A. Burke³, N. Salter⁴, S. O'Rourke⁵, A. Kruis⁶, A. Wakai⁷, S. Ahmed⁸, E. Turcuman², E. Siobhan¹, M. Watts¹
Abstract Number: PB0896

A Randomized Controlled Trial: Pharmacokinetic-Guided Dosing of Factor VIII Concentrate Versus Standard Replacement Therapy in Perioperative Hemophilia A Patients (OPTI-CLOT Trial)

I. van Moort¹, T. Preijers², L. Bukkems², H. Hazendonk¹, B. Laros-van Gorkom³, E. Beckers⁴, L. Nieuwenhuizen⁵, F. van der Meer⁶, P. Ypma⁷, M. Coppens⁸, K. Fijnvandraat^9,10, R. Schutgens¹¹, K. Meijer¹², F. Leebeek¹³, R. Mathot², M. Cnossen¹, OPTI-CLOT Study Group
Abstract Number: PB0957

A Randomized, Multicenter, Open-label, Phase III Clinical Trial to Evaluate the Efficacy, Safety, and Pharmacokinetics of Prophylactic Emicizumab Versus No Prophylaxis in Persons with Hemophilia A in the Asia-Pacific region (HAVEN 5)

S. Wang¹, X. Zhao², X. Wang³, J. Sun⁴, A. Chuansumrit⁵, J. Zhou⁶, L. Li⁷, W. Hsu⁷, J. Xu⁷, P. Barrington⁸, R. Yang⁹
Abstract Number: PB0774

A Rare Case of Acquired Haemophilia A with Platelet Dysfunction Associated with Non Hodgkin Indolent Lymphoma

R. Rossio¹, R. Cassin², A. Lecchi¹, A. Noto², C. Novembrino¹, M.E. Mancuso¹, B. Ferrari¹, G. Reda², F. Peyvandi^1,3
Abstract Number: PB1302

A Rare Case of Phlephlebitis; An Unusual Underlying Reason for Portal Venous Thrombosis

S. Aytac¹, N. Korgal², H. Hizacioglu³, A. Yuce³, F. Gumruk¹
Abstract Number: PB0875

A Real-World Qualitative Analysis of the Burden of Hemophilia B and Patient Experiences with Prophylactic Nonacog Beta Pegol

C. Phua¹, M. Faurby², V. Macdonald³, J. Lambert⁴, J. Teitel⁵
Abstract Number: PB0093

A Recurrent Ischaemic Stroke Case with Type 1 von Willebrand Disease

H.H. Şahin, D.M. Akkurd, V. Okan
Abstract Number: PB2255

A Retrospective Cohort Study on Splanchnic Vein Thrombosis

E. Kawata (Iida)^1,2, D.-A. Siew^1,3, J. Payne³, A. Xenocostas^1,3, M. Louzada^1,3, M. Kovacs^1,3, A. Lazo-Langner^1,3,4
Abstract Number: PB2315

A Retrospective Study of Incidence of Venous Thromboembolism (VTE) and Prevalence of Risk Factors Associated with VTE in Patients Undergoing Allogeneic Hematopoietic Stem Cell Transplantation: A Single-Center Experience

B. Ram S, K.S. Nataraj, S. Prabhu, H. Dalal, A. Polisetty, S. Kumar, A. Shah, R.G. Karthick, M. Harimadhavan, S. Damodar
Abstract Number: PB1551

A Retrospective Study to Evaluate the Efficacy and Safety of a Plasma-Derived, von Willebrand Factor-Containing FVIII Concentrate, in Patients with Von Willebrand Disease (VWD) in Spain: Interim Analysis Results

V. Jiménez-Yuste¹, R. Mir²
Abstract Number: PB1311

A Rise in Plasma Coagulability During the First 3 Months Following Provoked Venous Thromboembolism is Associated with the Development of Post-Thrombotic Syndrome in Children and Young Adults: Analysis of the Kids-DOTT Multicenter Trial-Derived Biobank

M. Betensky¹, E. Amankwah¹, S. Brandal², A.D. Everett², N.A. Goldenberg¹
Abstract Number: PB0224

A Sensitive and Specific Assay to Measure TF Activity in Cell-derived Extracellular Vesicles Based on Thrombin Generation

B. Østerud, N. Latysheva, O. Snir, J.-B. Hansen
Abstract Number: PB1166

A Simple Algorithm to Identify Emicizumab Interference in Samples Received in the Clinical Coagulation Laboratory

B. Poirier, E. McEwan, M. Robinson, R. Gode, S. Tiefenbacher
Abstract Number: PB1053

A Simplified Health Education Program Improves Knowledge and Practices of Home Treatment in Hemophilia A Adolescents in a Developing Country

T. Hassan¹, M. Hesham¹, A. El Dakhakhny², M. Zakaria¹, M. Hanfy²
Abstract Number: PB2285

A Simplified Management Strategy for Suspected Pulmonary Embolism: External Validation of the YEARS Diagnostic Algorithm

M. Eddy¹, L. Richardson², T. Moumneh³, G. Meyer⁴, M. Righini⁵, G. Le Gal⁶, H. Robert-Ebadi⁵
Abstract Number: PB0953

A Single Center Data on Extended Half-Life Recombinant Factor VIII (FVIII:Fc) in Patients with Hemophilia A

S. Braham¹, R. Gualtierotti², E. Biguzzi¹, S.M. Siboni¹, E. Bregani³, M. Boscarino⁴, M.E. Mancuso¹, F. Peyvandi^1,2
Abstract Number: PB2481

A Single Centre Experience on the Use of Direct Oral Anticoagulants in People with Human Immunodeficiency Virus (HIV)

S. Patel¹, A. Godfrey²
Abstract Number: PB2321

A Single-Centre Case Series of Venous Thromboembolic Disease

J. Portillo Sánchez¹, V. Quero Palomino²
Abstract Number: PB0382

A Single-Domain Antibody that Exerts an Anticoagulant Effect Dependent on Protein S

J.-C. Sedzro¹, F. Adam¹, A. De Carvalho¹, I. Peyron¹, E. Bianchini¹, S. Gandrille², S. Thomassen³, T.M. Hackeng³, O.D. Christophe¹, P.J. Lenting¹, C.V. Denis¹, D. Borgel^1,4, F. Saller¹
Abstract Number: PB1062

A Snapshot of a Prospective, Non-interventional Study to Evaluate Routine Practice Prophylactic Treatment Schedules – NIS-Previq

S. Halimeh¹, W. Behnisch², C. Escuriola-Ettingshausen³, J. Feddern⁴, A. Huth-Kühne⁵, J. Oldenburg⁶, U. Scholz⁷, S. Seeger⁴, S. Wenning⁵, R. Klamroth⁸
Abstract Number: PB0595

A Strategy for the Prenatal Diagnosis for Fetus with Hemophilia A without Genetic Defects

Y. Li¹, W. Jin¹, Q. Li², L. Li¹
Abstract Number: PB0312

A Strategy of Continued Antiplatelet Agents, Vitamin K Antagonists, and Direct Oral Anticoagulants throughout the Perioperative Period of Diabetic Foot Surgery in Patients Receiving Chronic Antithrombotic Therapy

Y. Volkova¹, D. Dmytriiev²
Abstract Number: PB0052

A Study on Pressure Overload-Induced Cardiac Hypertrophy Model in Mice by Applying Transverse Aortic Constriction and O-Ring Ascending Aortic Banding Technique: A Comparative Analysis

A. Rashid^1,2
Abstract Number: PB1369

A Subpopulation of ITP Patients Resembling Glanzmann Thrombasthenia Phenotype Revealed by Flow Cytometry Analysis of Platelet Intracellular Signalling

A. Martyanov^1,2,3, D.S. Morozova⁴, S.S. Uzueva³, M.A. Sorokina³, D.V. Fedorova³, P.A. Zharkov³, M.A. Panteleev^2,3,5, A.N. Sveshnikova^2,3,5
Abstract Number: PB2269

A Systematic Review and Meta-Analysis on Diagnostic Delay in Pulmonary Embolism

E.M. Trinks-Roerdink, R. van Maanen, G.J. Geersing
Abstract Number: PB0623

A Universal Quality Control Plasma for Anti-Xa and Anti-IIa Drugs

L. Pozzi¹, E. Pattarini², P. Della Valle³, A. D'Angelo³
Abstract Number: PB1777

A Validated Model for the Diagnosis of Periprosthetic Joint Infection with Coagulation-related Markers: TGT and NETs

J. Oto¹, Á. Fernández-Pardo¹, M. Fuertes², M.J. Solmoirago¹, E. Plana¹, D. Hervás³, F. Cana¹, C. De la Calva², M. Angulo², I. Baixauli², F. Baixauli², F. España¹, S. Navarro¹, J.V. Amaya², P. Medina¹
Abstract Number: PB1485

A Whole Blood Flow Cytometric Method for Diagnosis of Platelet Function Disorders

R.G. Dave¹, T. Geevar¹, R. V.¹, S. Singh¹, A. Abraham², A. Srivastava², S.C. Nair¹
Abstract Number: PB0954

Abdominal Catastrophe in Hemophilic Patients: Towards Wise Decision Making

M. Abdelkader Morad, M. Elkholy, M. Mattar, M. Hasab Allah, A. Ayad, S. Habib, G. Nashed
Abstract Number: PB2558

ABO Blood Groups and Inherited Thrombophilia in Women with Abortion

A. Poretto, L. Spiezia, E. Borella, G. Turatti, M. Marobin, E. Campello, P. Simioni
Abstract Number: PB0041

Absence of Protein Tyrosine Phosphatase-1B in Smooth Muscle Cells Promotes Perivascular Fibrosis: Role of Receptor Tyrosine Kinase Signaling

S. Gachkar, D. Velmeden, T. Münzel, K. Schäfer
Abstract Number: PB1614

Accelerated Death of Wiskott-Aldrich Syndrome Megakaryocytes

S. Obydennyi^1,2, O. Fedyanina^1,2, S. Kuznetsova^1,2, A. Khoreva², F. Ataullakhanov^1,2,3, A. Shcherbina², M. Panteleev^1,2,3
Abstract Number: PB0586

Accuracy of Commercial Universal Calibrators for Measurement of Heparin and Low Molecular Weight Heparin

J. Hogwood, E. Gray
Abstract Number: OC 10.3

Accurate and Efficient Non-Invasive Strategy for Early Identification of Chronic Thromboembolic Pulmonary Hypertension after Acute Pulmonary Embolism (InShape II Study)

G.J.A.M. Boon¹, Y.M. Ende-Verhaar¹, R. Bavalia², L.H. El Bouazzaoui³, M. Delcroix⁴, O. Dzikowska-Diduch⁵, M.V. Huisman¹, K. Kurnicka⁵, A.T.A. Mairuhu⁶, S. Middeldorp⁷, P. Pruszczyk⁵, D. Ruigrok⁸, P. Verhamme⁹, H.W. Vliegen¹⁰, A. Vonk Noordegraaf⁸, J.W.J. Vriend¹¹, F.A. Klok¹
Abstract Number: PB1754

Acetyl-CoA Carboxylase Inhibition Alters Tubulin Acetylation and Aggregation in Thrombin-stimulated Platelets

M. Octave¹, A. Ginion¹, L. Pirotton¹, V. Robaux¹, S. Lepropre¹, S. Kautbally¹, V.M. Darley-Usmar², J. Ambroise³, B. Guigas^4,5, M. Giera⁶, M. Foretz⁷, L. Bertand¹, C. Beauloye¹, S. Horman¹
Abstract Number: PB1759

Acetylation of α-Tubulin by Aspirin and Histone Deacetylase 6 in Human Platelets

A.M. Latorre¹, S. Bonanad², A. Moscardo²
Abstract Number: PB1177

Achenbach Syndrome in a 19 Year-Old Girl: A Clinical Case

D.O.W. Rodrigues¹, N.N.S. Magalhaes², O.F. Santos³, L.O.W. Rodrigues⁴
Abstract Number: PB1335

Achieving Clinically Relevant Platelet Count Response Thresholds with Avatrombopag (AVA) in Immune Thrombocytopenia (ITP)

I. Altomare¹, M. Vredenburg², W. Tian², K. Aggarwal²
Abstract Number: PB0475

Acquired Antithrombin III Deficiency Is a Risk Factor for Venous Thromboembolism after Severe Injury

E. Rahbar¹, B. Cotton², C. Wade², J. Cardenas²
Abstract Number: PB0773

Acquired Deficiency of Dependent Coagulation Factors of Vitamin K, at the Teaching Center: Experience In 10 Years

J. Daza^1,2, C. Casas^1,2, M.H. Solano^1,2
Abstract Number: PB1701

Acquired GPVI Deficiency Is a Biomarker for Early Diagnosis and Prognostic Assessment of Patients with Sepsis

L.J. Weiss¹, G. Manukjan¹, N. Nagler², M. Kredel³, T.-T. Lâm⁴, B. Nieswandt^1,5, D. Weismann², H. Schulze¹
Abstract Number: PB0162

Acquired Haemophilia Spanish Registry, First Five Years of Activity

M.E. Mingot-Castellano^1,2, J.M. Bastida-Bermejo³, S. Haya⁴, J. Pardos-Gea⁵, M.D.C. Fernandez-Sanchez de Mora⁶, R. Lluch⁷, R. Nuñez⁸, M.T. Alvarez-Roman⁹, I. Soto-Ortega¹⁰, J.M. Martín-Antoran¹¹, J.A. Rodriguez-Garcia¹², M. Carrasco-Exposito¹³, J.A. Rodriguez-Alen¹⁴, C. Cervero-Santiago¹⁵, M. Perez-Sanchez¹⁶, R. Rodriguez-Gonzalez¹⁷, N. Fernandez-Mosteirin¹⁸, M.N. Alonso-Escobar¹⁹, A. Moreto-Quintana²⁰, P. Marco-Vera²¹, Registro Español de Hemofilia Adquirida
Abstract Number: PB0795

Acquired Hemophilia A in Young Nulliparous Woman: A Case Report

E. You
Abstract Number: PB0780

Acquired Hemophilia in Argentina: A Multicentric Study

F. Chuliber¹, A. Sanchez Luceros², M.L. Romero², C. Duboscq³, M. Martinuzzo⁴, L. Beligoy⁵, M. Clavijo⁶, A. Pintos Marquez⁷, S. Garbiero⁸, M. Arias⁹, M.D.C. Gallo¹⁰, M. Del Castillo¹¹, A. Bonacina¹², D. Villalba¹³, A. Juarez Avignone¹⁴, J. Jerez¹⁵, V. Castoldi¹⁶, A. Lo Turco¹⁷, A. Baques⁹, D. Penchasky⁴
Abstract Number: PB1882

Acquired Thrombotic Thrombocytopenic Purpura: Key Findings of Patients from Southern Italy

G.L. Tiscia¹, F. Cappucci¹, L. Fischetti¹, C. Battista², A. Ostuni², G. Giordano³, G. Tarantini⁴, T.M. Santeramo⁴, G. Giuffrida⁵, D. Nicolosi⁵, P.R. Scalzulli⁶, N. Cascavilla⁶, L. di Mauro⁷, E. Grandone¹
Abstract Number: PB2295

Acquired Type II (IIb) Protein S Deficiency, Case Report

T. Fenclova¹, V. Geierova², M. Zemanova¹, P. Salaj², I. Hrachovinova¹
Abstract Number: PB1583

Acquired von-Willebrand-Disease (aVWD) in ECMO Patients: a 3-Year Cohort Study

T. Bajorat¹, B. Panholzer², A. Haneya², D. Kowalski¹, D. Juhl³, A. Rocke¹, M. Shneyder¹, P.M. Kuta¹, H. Clausnizer¹, U. Nowak-Göttl¹
Abstract Number: PB1785

Activated Factor XI Promotes Complement Activation by Neutralizing Complement Factor H

C. Puy¹, R.S. Keshari², C. Lorentz¹, E. Tucker¹, J. Morrissey³, S. Smith³, D. Gailani⁴, A. Gruber¹, F. Lupu², O. McCarty¹
Abstract Number: OC 06.4

Activated Protein C Reverses the p21-Mediated Hyperglycemic Memory in Diabetic Nephropathy

A. Elwakiel¹, M.M. Al-Dabet¹, K. Shahzad¹, A. Sulaj², C. Dockendorff³, R. Geffers⁴, J. Griffin⁵, S. Kohli¹, B. Isermann¹
Abstract Number: PB0381

Activated Protein-C up Regulates Microparticles Release from Ovarian Cancer Cell Line

S. Besbes¹, R. Attal¹, S. Mirshahi^1,2, M. Pocard¹, J. Soria¹, M. Mirshahi¹
Abstract Number: PB1111

Activated Prothrombin Complex Concentrates for the Management of Direct Oral Anticoagulant-Associated Bleeding Events and Pre-Operative Administration for Urgent Surgery: Hemostatic and Thrombotic Outcomes

J. Shaw¹, M. Carrier¹, D. Dowlatshahi², S. Chakraborty³, M. Tokessy⁴, H. Buyukdere⁴, L. Castellucci¹
Abstract Number: PB0154

Activated recombinant Factor VII (rFVIIa) Inhibitor in Iran: Immunogenicity is a Major Challenge through Treated Bleeds Covered with rFVIIa

P. Eshghi¹, M. Ahmadinejad², M. Karimi³
Abstract Number: PB0249

Activation of Coagulation by 5.8S RNA

A. Alharbi, R. Raman, N. Iyer, A. Al Qaryoute, D. Burks, R. Azad, P. Jagadeeswaran
Abstract Number: PB2013

Activation of ERK Signaling Pathway by Plasma IgG in Venous Thromboembolism Patients without Antiphospholipid Antibodies

S. Bouvier^1,2,3, S. Bastide⁴, M. Fortier¹, J. Laurent⁵, E. Mercier^1,2,3, E. Nouvellon¹, A. Remy¹, G. Lavigne¹, I. Quéré⁶, A. Pérez-Martin^2,5, J.-C. Gris^1,2,3
Abstract Number: PB0462

Active Thrombin and its Value: New Approach to Diagnosis of Thrombosis?

J. Stikarova, J. Dyr
Abstract Number: PB1103

Activity Measurement of Factor IX Padua against the 4^th International Standard for FIX, Plasma

E. Gray¹, A. Riddell², J. Foley³, D. Verhoef³, R. Corbau³, A. Nathwani^2,3
Abstract Number: PB0394

Acute Deep Vein Thrombosis Is Associated with Increased Platelet Thrombin Generation and Increased Procoagulant Oxidised Phosphatidylethanolamine

S.G. Obaji¹, D.A. Slatter², V.J. Tyrrell², P.V. Jenkins¹, V.B. O'Donnell², P.W. Collins¹
Abstract Number: PB1820

Acute Exacerbations of COPD Induce a Prothrombotic State through Platelet-Monocyte Complexes, Endothelial Activation and Increased Thrombin Generation

L.N. van der Vorm^1,2,3, L. Li^2,3, D. Huskens^2,3, J. Hulstein¹, M. Roest^2,3, P.G. de Groot³, H. ten Cate³, B. de Laat^2,3, J. Remijn^1,3,4, S. Simons^5,6
Abstract Number: PB0113

Acute Leriche Syndrome in a 55-Year-Old Woman with Recurrent Central Pulmonary Embolism: A Case Report

V. Muster¹, P. Jud¹, K. Gütl¹, M. Tomka², A. Baumann², M. Anelli-Monti³, P. Srekl-Filzmaier³, R.H. Portugaller⁴, M. Brodmann¹, T. Gary¹
Abstract Number: PB0360

ADAMTS-13/VWF as Biomarker for Portal Vein Thrombosis Development in Cirrhotic Patients: A Prospective Study

M. Sacco¹, S. Lancellotti², A. De Magistris³, M. Tardugno⁴, M. Basso², M. Pompili^4,5, R. De Cristofaro^4,6
Abstract Number: OC 07.2

ADAMTS13 Conformation Is Closed in Acquired Thrombotic Thrombocytopenic Purpura in the Absence of Anti-ADAMTS13 Autoantibodies

E. Roose¹, B.S. Joly^2,3, A.-S. Schelpe¹, I. Pareyn¹, A. Vandenbulcke¹, C. Tersteeg¹, S.F. De Meyer¹, P. Coppo⁴, A. Veyradier^2,3, K. Vanhoorelbeke¹
Abstract Number: PB1429

Addition of Exogenous Platelet Factor 4 in the Heparin Induced Platelet Activation (HIPA) Assay for the Detection of Pathogenic Heparin-induced Thrombocytopenia Antibodies

D. Faille, M.-C. Bourrienne, N. Ajzenberg
Abstract Number: PB0227

Addition of Histone Deacetylase Inhibitors Increases Recombinant Factor V Expression in BHK Cells

T. Petrillo¹, J.C. Small¹, R.M. Camire^1,2
Abstract Number: PB1093

Adenovirus Mediates Expression of Human Coagulation Factor IX Gene in Adipose-Derived Mesenchymal Stem Cells

Z.Y. Yan¹, X. Wang², J. Li³, Y. Xie³, L. Wang³, Y. Zhu³, H. He³, Q. Sun³
Abstract Number: PB0368

Adhesive Properties of Plasma-Circulating and Platelet-Derived Microvesicles

E. Artemenko^1,2, D. Nechipurenko^1,2,3, S. Obydennyi^1,2, M. Panteleev^1,2,3
Abstract Number: PB0479

Administration of Fibrinogen vs. Cryoprecipitate Stored out to 10 Days in Microfluidic Models of Coagulopathies in Hemorrhage

S.M. Shea, K.A. Thomas, P.C. Spinella
Abstract Number: PB1570

Adolescent Menorrhagia and Von Willebrand Disease

Y. Ouarhlent, M.R. Makhloufi
Abstract Number: PB0787

Advanced Principles of Prevention and Treatment of Preeclampsia in Women with Antiphospholipid Syndrome (APS) and MTHFR C677T Mutation

M. Jangidze¹, N. Kintraia², P. Zhorzholiani³, T. Saralidze⁴, N. Metskhvarishvili², M. Rizvadze²
Abstract Number: PB0687

Advancing the Understanding and Significance of Genetic Testing Results in Hemostasis/Thrombosis

K. Lee¹, D. DeMille², K. Gomez^3,4, W. Kahr⁵, M. Lambert⁶, D. Lillicrap⁷, D. McDougal¹, S. Mohan¹, P. Morange⁸, A. Mumford⁹, J. Ross¹, J. Zehnder¹⁰, J. Berg¹, N. Key¹¹, on Behalf of the ClinGen Hemostasis/Thrombosis Clinical Domain Working Group Executive Committee
Abstract Number: PB0962

Adverse Event Reporting in Haemophilia A Patients with and without Inhibitors Treated with Emicizumab: A Report from the Co-morbidity Working Party of the UK Haemophilia Centres Doctors´ Organisation (UKHCDO)

C. Wall¹, G. Hall², P. Collins³, M. Makris⁴, S. Shapiro⁵, R. Liesner⁶, C. Harrison⁴, R. Maclean⁴, S. Mangles⁷, G. Benson⁸, G. Evans⁹, P. Sartain¹⁰, C. Hay¹¹, UK National Haemophilia Database
Abstract Number: PB2189

Afibrinogenemia and Leiden FV Within the Same Family

S. Hadjali-Saichi¹, K. Guenounou-Guemmour¹, D. Helley-Russick², P. De Mazancourt³, I. Frigaa¹
Abstract Number: PB1199

Afibrinogenemia: Identification of a New Mutation in FGB

E. Chinni¹, G.L. Tiscia¹, G. Favuzzi¹, B. Bruschi², P. Coccia², I. D'Alba², S. Gobbi², V. Petroni², P. Pierani², F. Cappucci¹, L. Fischetti¹, P. Vergura¹, G. Vecchione¹, A. De Laurenzo¹, D. Colaizzo¹, E. Grandone¹
Abstract Number: PB0083

African American Women with Diabetes Undergoing Catheterization Represent Most Prothrombotic Subgroup: An Explanation for the Platinum Diversity Study Results?

U. Tantry¹, K. Bliden¹, R. Chaudhary², P. Gurbel³
Abstract Number: PB2015

Ageing Affects Neutrophils – Changes in Activation, DNA Release and Neutrophil Extracellular Formation of Neutrophil Subpopulations with Human Age

L.-M. Mauracher¹, M. Krall¹, J. Roiß¹, L. Hell¹, A.S. Ondracek², J. Gebhart¹, C. Brostjan³, C. Ay¹, I. Pabinger¹
Abstract Number: PB0703

Algorithm for Detection of Procoagulant Samples with Elevated Prothrombin and Reduced Antithrombin by their Ability to Deplete Fluorogenic Thrombin Substrate

W. Chang¹, K. Machlus², A. Wolberg², M. Ovanesov¹
Abstract Number: PB0241

Allosteric Modulation of Exosite 1 Attenuates the Enhancing Effect of Polyphosphate on FXI Activation by Thrombin

R. Yin^1,2, V. Patel^1,2, E. Ajewole¹, J. Fredenburgh^1,3, J. Weitz^1,3
Abstract Number: PB2012

Altered Coagulation Parameters and D-Dimer Measurements in Sepsis Are Useful in Scoring the Risk Stratification

D. Joshi¹, E. Bontekoe¹, M. Rondina², E. Middleton², A. Blair², F. Siddiqui¹, D. Hoppensteadt¹, J. Fareed¹
Abstract Number: PB0668

Altered FIBTEM/Fibrinogen Correlation in Liver Transplant Patients Relative to Cardiac Surgery Patients

E. Salazar¹, S. Lindberg², C. Leveque¹, B. Castillo¹, J. Chen¹
Abstract Number: PB2532

Alternative Complement Pathway Activation in the Severe Hypertensive Disorders of Pregnancy

R. Neki^1,2, T. Miyata³, K. Ohtani⁴, Y. Hidaka⁵, K. Ida¹, T. Yokouchi-Konishi², A. Nakanishi², J. Yoshimatsu², K. Kokame⁶, N. Wakamiya⁷, N. Inoue⁵
Abstract Number: PB0239

Always Ask Relevant Questions to Patients Might Be They Tell You the Diagnosis

A. Naz¹, T. Masood², N. Saqlain³, N. Samad⁴, T. Shamsi⁵
Abstract Number: PB2097

Amelioration of the Pathologic Changes in the Hepatocyte-Specific BRAFV600E Mutated Mice by Administration of Aspirin

H. Tanaka¹, K. Horioka², K. Yamazaki³, K. Ogawa⁴
Abstract Number: PB1700

An Activation-dependent Pathway Modulated by Dicer1 Neosynthesis and Down-regulating Platelet Reactivity Is Impaired in Diabetes

E. Piselli¹, L. Bury¹, G. Manni¹, S. Momi¹, C. Fanelli², G. Perriello², P. Gresele¹
Abstract Number: PB1729

An Artificial Lipid Membrane Platform as an Approach to Study CLEC-2 Receptor Clustering

M.A. Sowa^1,2, Y. Di³, S.P. Watson³, J.M. Gibbins¹, Á. García², A.Y. Pollitt¹
Abstract Number: PB2270

An Assessment of the Cost-Effectiveness of Whole-Leg Ultrasound Scans Compared to Proximal Leg Vein Ultrasound Scans in the Diagnosis of Acute Deep Vein Thrombosis

G. Bertone¹, Z. Lester², H. Rowswell², T. Nokes², W. Thomas²
Abstract Number: PB2379

An Audit Examining Information Provided to Patients Regarding Venous Thromboembolism (VTE) at Discharge

K. Karia, S. Parikh, G. Lowe
Abstract Number: PB0481

An Audit of Fresh Frozen Plasma Transfusions: Justified or Not?

A. Memon¹, F. Qaisar²
Abstract Number: PB1635

An Elevated Platelet Count Increases the Rate of Prothrombin Activation, but Not the Total Amount of Thrombin Formed

Q. Yan^1,2, M. Ninivaggi¹, B. de Laat¹, R. de Laat-Kremers¹
Abstract Number: PB0614

An Evaluation of the Assay Performance of the Antifactor Xa Assay for Rivaroxaban

V. Prasad, H.J. Yeo, S. Abdul Latiff, M.S. Wong
Abstract Number: PB2469

An Evaluation of the Basis for Anti-Xa Testing in Patients on Low Molecular Weight Heparin and its Impact on Subsequent Management

S.H. Yeang¹, W.M. Tan¹, E.Y. Kuo¹, Y.T. Shim¹, W.S.J. Loke², W.H. Wong², M.A. Cheong², C.W. Tan², H.J. Ng²
Abstract Number: PB0626

An Evaluation of Treatment Monitoring in Patients with VWD Using a Chemiluminescent (VWF:GP1bR) Assay Compared to a Lyophilised Platelet Assay with Ristocetin (VWF:RCo)

A. Riddell¹, L. Lanning¹, S. Vinayagam¹, T.T. Yee², P. Chowdary²
Abstract Number: PB0556

An Improved Algorithm for the Detection of Lipemia as Interfering Substances on a Fully Automated Coagulation Analyzer

K. Sass¹, J. Kramer², O. Bätz², S. Echternacht¹, S. Crombach³
Abstract Number: OC 09.3

An Insight into Clinical Outcomes in Mild, Moderate, and Severe Hemophilia A (HA): A Preliminary Analysis of the CHESS II Study

F. Nissen¹, T. Burke², S. Asghar², E. Ferri Grazzi², A. Shang¹, F. Castro¹, M. Aizenas¹, O. Meier¹, J. O'Hara^2,3
Abstract Number: OC 09.2

An International Multicenter Study of Bevacizumab for Bleeding in Hereditary Hemorrhagic Telangiectasia (The InHIBIT-Bleed Study)

H. Al-Samkari^1,2, R. Kasthuri³, J. Parambil⁴, H. Albitar⁵, Y. Almodallal⁶, C. Vazquez⁷, M. Serra⁷, S. Dupuis-Girod⁸, C. Wilsen⁹, J. McWilliams⁹, E. Fountain¹⁰, J. Gossage¹⁰, C. Weiss¹¹, M. Latif¹¹, A. Issachar¹², M. Mei-Zahav¹³, M. Meek¹⁴, M. Conrad¹⁵, D. Kuter^1,2, V. Iyer¹⁶
Abstract Number: PB0582

An International Study on the Interpretation of Test Results of the APTT Mixing Test

P. Meijer¹, J.M. Bauça², É. Ajzner³, A. Hillarp⁴, A.H. Kristoffersen^5,6, Working Group on the Postanalytical Phase (EFLM / EQALM)
Abstract Number: PB1206

An Italian Survey on the Real-world Use of rFXIII (Catridecacog) in Patients with Factor XIII Deficiency

E. Zanon¹, S. Pasca¹, G. Sottilotta², A.C. Molinari³, L. Banov³, A. Ferretti⁴, P. Di Gregorio⁵, B. Pollio⁶, S.M. Siboni⁷, R. Palla⁷, L. Spiezia⁸, M. Pizzuti⁹, L.D. Notarangelo¹⁰, P. Simioni¹¹
Abstract Number: PB2086

An observational Study of INR Control and Bleeding Events, According to European Society of Cardiology (ESC) Guidelines, in Non-valvular Atrial Fibrillation (NVAF) Stratified by Male and Female Sex

D. Harris¹, F. Torabi¹, R. Alikan², A. Akbari¹, D. Mallory¹, D. Thayer¹, T. Wang¹, S. Grundy³, S. Lister⁴, M. Gravenor¹, J. Halcox¹
Abstract Number: PB0343

An Overview of Patients with Hemophilia A in China: Epidemiology, Disease Severity, and Treatment Strategies

X. Song¹, J. Zhong², F. Xue¹, L. Chen¹, H. Li¹, D. Yuan¹, J. Xie², J. Shi¹, L. Zhang¹, E.Q. Wu², R. Yang¹, Analysis Group, Inc., Beijing, China
Abstract Number: PB1947

An Unusual Case of Cerebral Cavernous Malformation Complicated with Consumptive Coagulopathy and Heightened Fibrinolysis

M.-C. Shen¹, C.-Y. Lin¹, W.-L. Chen², Y.-H. Shih¹, Y.-C. Huang³
Abstract Number: PB0457

Analysis of Biomarkers of Hemostatic Dysregulation and Inflammation in Lymphoma Patients

D. Antic¹, V. Otasevic¹, E. Bontekoe², F. Siddiqui², D. Hoppensteadt², N. Baig², J. Sinacore², V. Djurasinovic¹, V. Vukovic¹, K. Tomic¹, B. Mihaljevic¹, J. Fareed²
Abstract Number: PB2300

Analysis of Hemodynamic and Hemocoagulation Changes in Mortality Structure in Polytrauma Patients

Y. Volkova, N. Baranova
Abstract Number: PB0550

Analysis of Megathrombocytes as a New, Fast, and Low Cost Tool to Indicate Thrombosis and Predict Prognosis in Sickle Cell Disease

L.W. Serrao¹, E.F.N. Silva Lisboa², P.F. Rosa de Siqueira³, M.C. Canellas da Silva¹, J. Medeiros⁴, A. Soares⁵, M.K. Fleury¹
Abstract Number: PB2443

Analysis of Outcomes Following Inferior Vena Cava (IVC) Filter Placement in a Single Center Population

C. Enciso¹, N. Torres², J.M. Freue¹, J. Scapellato², R.M. Campestri¹
Abstract Number: PB0778

Analysis of Patients with Diagnosis of Adquired Haemophilia in a Third Level Hospital

A. Gómez Martínez¹, M. Villalba Montaner², E. Salvador Rupérez¹, A. García Ortego¹, S. Pinzón Mariño¹, S. Martín-Consuegra Ramos¹, C.F. Hernández Mata¹, M. Moreno Carbonell¹, E. González Gómez¹, J.M. Calvo Villas¹, N. Fernández Mosteirín¹, P. Delgado Beltrán¹
Abstract Number: PB0630

Analysis of Platelet Functional Activity by Flow Cytometry: Reference Intervals and Cut-off Value for Evaluating the Efficiency of Antiplatelet Therapy

A. Ermakov^1,2, L. Gaykovaya^1,2, O. Sirotkina^1,3, T. Vavilova¹
Abstract Number: PB2505

Analysis of Population Values in Pregnant Women

M.L. Iglesias Varela¹, M. Siracusa¹, M. Paz¹, D. Jacobsen¹, N. Salguero², L. Maggi¹
Abstract Number: PB0573

Analytical Performance Validation of the T-TAS 01 PL Assay

J. Dahlen¹, K. Dobashi², W. Yuan², S. Ishikawa², K. Hosokawa²
Abstract Number: PB0638

Analytical Validation of a Novel Whole Blood Coagulometer for NOAC Testing

S. Bakhru¹, X. Jiang¹, L. Chen¹, Y. Wang¹, D. Osmani¹, D. Mootoo¹, J. Ansell², S. Zappe¹
Abstract Number: PB0348

Analytical Variability (CV) of One Stage Factor VIII Assay: A Quality Control (QC) Experience. Argentinian Group of Biochemists in Hemophilia

M.D.V. Arias¹, E. Sueldo¹, G. Detarsio²
Abstract Number: PB0616

Analytical Verification of Automated Latex-Enhanced Particle Immunoturbidimetric D-Dimer Assays on Diferent Analytical Platforms and Comparability of Test Results

I. Lapić¹, S. Prpić², A. Prce³, D. Coen Herak¹, R. Zadro^1,4, D. Rogić^1,4
Abstract Number: PB1431

Anaphylactic Shock to Apixaban in a Patient Treated for Heparin-induced Thrombocytopenia (HIT)

M. Afonso¹, A.G. Lopes², R. Cardoso Araújo³, M. Vasconcelos³, A.P. Barbosa¹, A. Marques¹
Abstract Number: PB1119

Andexanet and Prothrombin Complex Concentrate Give Comparable Haemostatic Efficacy for Major Bleeding in Patients on Factor Xa Inhibitors

T.C.C. Jaspers¹, K.N. Shudofsky², M.V. Huisman³, K. Meijer⁴, N. Khorsand⁵
Abstract Number: PB0839

Animal Model Construction for Hemophilic Arthritis: Evaluation of Hemophilia Joint by Ultrasound Detection

H. Liu¹, C. Xu¹, Y. Li¹, J. Sun², F. Ma¹, Y. Zhang¹, Y. Gao¹, M. Yi¹, Z. Xu¹
Abstract Number: PB0124

Anti-Aggregant Effect of Butanolic Extract of Rubia Tinctorum on Platelets in vitro and ex vivo

F.Z. Marhoume¹, Y. Zaid², A. Alioua³, A. Chait⁴, A. Bagri¹
Abstract Number: PB1784

Anti-complement Effect of Heparin in Stimulated Whole Blood

J. Hogwood¹, Y. Qiao², S. Pitchford², C. Page², B. Mulloy², E. Gray^1,2
Abstract Number: PB0226

Anti-factor V Inhibitor after Liver Transplantation

A. Ciavarella¹, A. Artoni¹, M. Capecchi¹, S. Bhoori², V. Mazzaferro², C. Novembrino¹, A. Cairo¹, M. Clerici¹, C. Valsecchi³, F. Peyvandi¹, I. Martinelli¹
Abstract Number: PB1796

Anti-Platelet Drug Ticagrelor Has a Direct Anticancer Activity

O. Elaskalani¹, P. Metharom^1,2
Abstract Number: PB1919

Anti-β2-Glycoprotein I and Anti-Prothrombin Antibodies Cause Lupus Anticoagulant by Interfering with Factor Xa-Mediated Factor V Activation

T. Noordermeer¹, J.E. Molhoek², S.A.E. Sebastian², S. Drost-Verhoef², A.C.W. van Wesel², P.G. de Groot³, J.C.M. Meijers^4,5, R.T. Urbanus¹
Abstract Number: PB0104

Antiaggregation Evaluation of Aspirin and Clopidogrel in Endovascular Treatment of Intracranial Aneurysms with Flow Diverter Stents

A. Moscardo¹, F. Aparici², F. Ferrando¹, A. Blanquer¹, A.M. Latorre³, P. Bosch³, S. Bonanad¹
Abstract Number: PB1637

Antibodies Protect Platelets against Streptococcus Pneumoniae Toxin Pneumolysin

S. Handtke¹, K. Jahn², R. Palankar³, T.P. Kohler², S. Hammerschmidt², A. Greinacher¹
Abstract Number: PB0424

Anticoagulant Activity in Unclassified Bleeding Disorders

D. White¹, S. MacDonald¹, J. Langdown¹, K. Downes^2,3, W. Thomas¹
Abstract Number: PB0213

Anticoagulant Effect of Novel Nanoparticles Functionalized with Synthetic Piperazinone Derivatives as FXa Inhibitors

J. Salazar^1,2, C. Rojas², F. Santana-Romo², A. Romero Bohorquez³, C. Vilos⁴, F. Zacconi^2,5
Abstract Number: PB0182

Anticoagulant Effects of Parenteral Sulodexide as Measured by Activated Clotting Time. Relevance to Dosing in Various Indications

B. Daravath¹, J. Fareed¹, O. Iqbal¹, A. Kouta¹, D. Hoppensteadt¹, W. Jeske¹, F. Siddiqui¹, M. Lewis¹, B. Lewis²
Abstract Number: PB2074

Anticoagulant Management Strategies in Cancer Patients with Atrial Fibrillation in Daily Clinical Practice

G. Chu¹, M.V. Huisman¹, H. Gelderblom², M.E. Hemels^3,4, T. van der Hulle², S.A. Trines⁵, F.A. Klok¹
Abstract Number: PB2442

Anticoagulant Therapy for Splanchnic Vein Thrombosis in Patients with Liver Cirrhosis: A Systematic Review and Meta-Analysis

E. Valeriani¹, M. Di Nisio², N. Riva³, O. Cohen^4,5, E. Porreca¹, M. Senzolo⁶, A. De Gottardi⁷, M. Magaz⁸, J.-C. Garcia-Pagan⁸, W. Ageno⁹
Abstract Number: PB2254

Anticoagulant Therapy for Splanchnic Vein Thrombosis: A Systematic Review and Meta-Analysis

E. Valeriani¹, M. Di Nisio², N. Riva³, O. Cohen^4,5, J.-C. Garcia-Pagan⁶, M. Magaz⁶, E. Porreca¹, W. Ageno⁷
Abstract Number: PB2460

Anticoagulation Control with the Point-of-Care INR: A Retrospective Pre-/Post-analysis

N. Riva¹, S. Meli², C. Borg Xuereb³, W. Ageno⁴, M. Makris⁵, A. Gatt¹
Abstract Number: PB2517

Anticoagulation for Women with Mechanical Heart Valves during Pregnancy: A Survey

I. Malhame¹, M. Othman^2,3, P. Casais^4,5, R. D'Souza⁶, R. Wald^7,8, C.K. Silversides^7,8, M. Sermer⁶, N. Shehata^9,10
Abstract Number: PB2445

Anticoagulation in Cirrhosis: Thrombin Generation Assay vs Anti FXa Activity

S. Pons^1,2, M.D.L. Herrera^1,2, A. Grinspon¹, A. Scazziota^1,2
Abstract Number: PB2055

Anticoagulation in Non-Valvular Atrial Fibrillation: Old or New Friends?

M.-A. Gaman¹, E.-C. Dobrica², M.-A. Cozma², C.C. Diaconu³
Abstract Number: PB2069

Anticoagulation Resumption After Intracerebral Hemorrhage in Two Cohorts of Patients Treated with Vitamin K Antagonists and Direct Oral Anticoagulants

D. Poli¹, E. Antonucci², E. Vignini¹, L. Martinese¹, S. Testa³, G. Guazzaloca⁴, P. Simioni⁵, V. Pengo⁵, P. Pignatelli⁶, A. Falanga⁷, L. Masciocco⁸, D. Barcellona⁹, A. Ciampa¹⁰, P. Chiarugi¹¹, C. Paparo¹², E. Bucherini¹³, M. Marzolo¹⁴, W. Ageno¹⁵, G. Palareti²
Abstract Number: PB2154

Anticoagulation Therapy as Prevention of Cancer Relapce

A. Vorobev, A. Makatsariya, V. Bitsadze, J. Khizroeva, A. Solopova, V. Sannikova, S. Petrova
Abstract Number: PB2159

Anticoagulation Therapy Management in Oncological Patients: Experience in a Center

A. Pimentel Feliciano, A. Ortiz López, M. Dobón Rebollo, L. Palomera Bernal, O. Gavín Sebastián
Abstract Number: PB0166

Anticoagulation with the Novel, Small-molecule Factor XIa (fXIa) Antagonist, EP-7041, Prevents Oxygenator Clotting but Conserves Hemostasis in a Canine Extracorporeal Circulation (ECMO) Model

M.A. Kurz¹, C.V. Pollack, Jr.¹, J.M. Connors², J.H. Levy³, C. Drummond⁴, D. Klein⁵, H.D. Josuns⁵, R. Pielemeier⁴, J. Buchino⁴, P. Osborne⁴, N.J. Hayward¹
Abstract Number: PB0571

Antifactor Xa Levels vs. Activated Partial Thromboplastin Time for Monitoring Unfractionated Heparin

V.M. Silva¹, C. Cavalheiro², C.C. Strunz³
Abstract Number: PB2168

Antimetastatic Profile of Bovine Intestinal Heparin and its Low Anticoagulant Activity Derivative

M. Sá Pereira^1,2, K.V. Micheli¹, C.R. Fernades¹, A.C.E.S. Vilela-Silva^2,3, A.G.F. Lima⁴, A.L. Guedes¹, F.F. Ferreira⁵, A.M.F. Tovar^1,2, M.S.G. Pavão^1,2, P.A.S. Mourão^1,2
Abstract Number: PB1377

Antimicrobial Prophylaxis in Patients with Immune Thrombocytopenia Treated with Rituximab: A Retrospective Multicenter Analysis

S. Raso¹, M. Napolitano², G. Arrigo¹, F. Reale¹, P. Silimbiani³, A. Lucchesi⁴, A. Maggio⁵, G. Calvaruso⁵, U. Consoli⁶, M.F. Mansueto¹, S. Siragusa²
Abstract Number: PB0029

Antioxidant Defense Gene Polymorphism in the Nenets Population

N. Vorobyeva¹, N. Belova², A. Vorobyeva², S. Nemanova¹
Abstract Number: PB1911

Antiphospholipid Antibodies “Multi-Positivity” in Women with Thromboembolism

J. Khizroeva, V. Bitsadze, N. Makatsariya, M. Arslanbekova, K. Sultangadzhieva, A. Vorobev, I. Khamani, N. Babaeva, A. Antonova
Abstract Number: PB0011

Antiphospholipid Antibodies in Acute Myocardial Infarction

Y. Zhang, X. Wang, Z. Yu, Z. Zhou
Abstract Number: PB2022

Antisense Oligonucleotide Targeting of Thrombopoietin Represents A Novel Platelet Depletion Method to Assess the Role of Platelets During Inflammation Resolution

T. Barrett¹, B. Wu¹, A. Revenko², A.R. Macleod², L. Segal¹, J. Berger¹
Abstract Number: PB1312

Antithrombin Activity Level below 60% in Children Has Implications for Heparin (LMWH) Dosing

I. Regan¹, C. Pillion², M. Riordan³, B. Nolan¹
Abstract Number: PB2450

Antithrombin III Levels Immediately Following Acute Venous Thromboembolism

C. Kabrhel^1,2, R. Rosovsky^3,4, N. Giordano¹, H. Zheng⁵
Abstract Number: PB0179

Antithrombotic Effects of a Novel Small Molecular Fxia Inhibitor BMS-986177/JNJ-70033093 in a Rabbit AV-Shunt Model of Thrombosis

X. Wang, Q. Li, F. Du, N. Shukla, A. Nawrocki, M. Chintala
Abstract Number: PB2367

Antithrombotic Offices of the Arkhangelsk Region Russia

N. Vorobyeva¹, A. Vorobyeva²
Abstract Number: PB0144

Antithrombotic Properties of Carvedilol Shown in Two Independent Intravital Real Time Models of Thrombosis

P. Czajkowski¹, D. Jarmoc², T. Rusak², K. Kramkowski²
Abstract Number: PB2452

Antithrombotic Stewardship: A Novel Approach to Appropriate Anticoagulant Prescription

M. Koolian^1,2, R. Kerzner³, N. Kampouris³, H. Mantzanis³, S.R. Kahn^1,2,4
Abstract Number: PB2543

Antithrombotic Therapy (Nadroparin Calcium) in the Prevention of Pregnancy Loss in aPL-Positive Women

V. Bitsadze¹, J. Khizroeva¹, E. Orudzhova², A. Shkoda², E. Bayanduryan³, M. Novosartyan³, A. Makatsariya¹
Abstract Number: PB1469

Antithrombotic Therapy by Charged Nanoparticles

M. Griffin¹, K. Ashworth², J. Di Paola², D. Ku¹
Abstract Number: PB2535

Antithrombotic Therapy for Pregnant Woman with Bland-White-Garland Syndrome and Prosthetic Mitral Valves

M. Arslanbekova, A. Makatsariya, J. Khizroeva, V. Bitsadze, K. Sultangadzhieva, N. Babaeva
Abstract Number: PB1327

Antithyroid Treatment Improves Thrombocytopenia in a Young Patient with Graves´ Disease: A Case Report

V.V. Palmieri, G. Lassandro, A. Amoruso, V. Palladino, C. Pastore, P. Giordano
Abstract Number: PB1965

Aortic Ring Angiogenesis Proceeds Normally Despite Minimal Tissue Factor Expression

J. Xu¹, L. Sommerville¹, N. Mackman², M. Hoffman^1,3
Abstract Number: PB0853

APC: A New Suspect in the Hunt for a Mechanism of Bone Disease in Hemophilia

G. Goldscheitter^1,2, J.A. Taylor^1,2, R.F. Klein^1,2
Abstract Number: PB2140

Apixaban Levels In Cancer-Associated Thrombosis In Low-Weight Individuals

V. Bravo-Villa¹, J. Romero², E. Rojas-Saldivar², R. Villa², M. Cervantes-Alarcón², P. Baz², G. Cesarman Maus²
Abstract Number: PB0606

Apixaban Plasma Concentration Estimation by Anti Xa Activity Assay Calibrated with Heparin Calibrators with 2 Different Reagent/Systems

M.M. Martinuzzo^1,2, E. Sueldo³, M.S. López^2,4, C. Duboscq⁵, E.S. Viñuales^6,7, D. Mezzarobba⁸, J. Ceresetto⁵, L.H. Barrera^9,10, M. Arias³, M. Gurfinkiel¹¹, J. Oyhamburu^7,9
Abstract Number: PB2399

Apixaban versus Heparin/Warfarin Treatment in Pulmonary Embolism: Results from the UK Apixaban Length-of-Stay Pulmonary Embolism – Hospital Admissions Study (ALPHA-PE)

R. Alikhan¹, C. Church², S. Shapiro³, S. Lister⁴, S. Chattree⁵, N. Smith⁶, C. Bomken⁷, S. Grundy⁴, J. Gordon⁸, D. Sugrue⁸, N. Hill⁴, L. Howard⁹
Abstract Number: PB0361

APML: 2 Cases of Discordant Coagulation Results and ROTEM Testing

A. Chee, K. Lewis, B. Conway, R. Howman, C. Grove
Abstract Number: PB2346

Apo(a) Polymorphisms rs3798220 and rs10455872 in a Brazilian Population of Deep Venous Thrombosis Pacients

I. Macedo Toni¹, M. Carmen Goncalves Lopes Fernandes¹, A. Lamônica¹, S.A. de Lima Montalvão¹, J.M. Annichino Bizzacchi^1,2
Abstract Number: PB0072

Apolipoprotein A-IV Is an Endogenous Inhibitor of Thrombosis: The Roles of Polymorphisms in the Risk of Cardiovascular Disease

S.-Y. *Yu^1,2, D. *MacKeigan^1,3, M. Neves^1,3,4, P. Chen^1,4, H. Ni^1,3,4
Abstract Number: PB0483

Apoptosis Inhibition during Cold Storage of Apheresis Platelet Concentrates Improves Cell Vitality without Affecting the Functionality

I. Marini¹, Y. Tamamushi¹, L. Pelzl¹, K. Althaus^1,2, S. Nowak-Harnau², T. Bakchoul^1,2
Abstract Number: PB1328

Apoptotic Markers May Help in Predicting the Disease Course of Pediatric Immune Thrombocytopenic Patients

S. Levy Mendelovich¹, S. Aviner², N. Sharon³, H. Miskin⁴, J. Yacobovich⁵, G. Kenet¹, H. Hauschner⁶, N. Rosenberg¹
Abstract Number: PB0585

Application of EP15A3 and EP15A2 Protocols to Verify the Performance of a Coagulometer in the Coagulation Laboratory of the National Institute of Respiratory Diseases in Mexico City

B.S. Zuñiga Ascencio¹, F. Vidal Martinez², M. J. Castillejos López, B. A. Lira Mendoza, M. E. Jaime Capetillo, E. Juárez Silva, Ma. A. Rodríguez Ventura, R. Guevara Gutiérrez
Abstract Number: PB1257

Application of the First Russian Biosimilar of Recombinant Clotting Factor VII in an Infant with Antenatal Cryptogenic Hepatitis and Bleeding Developed After Laparosopic Liver Biopsy

K. Papayan¹, L. Zhukova¹, I. Myznikova¹, A. Syrtsova¹, E. Kuchina¹, A. Taukov¹, E. Trizna¹, A. Yakovlev¹, A. Podkamenev¹, D. Kudlay², N. Nemstsveridze¹
Abstract Number: PB2524

Approach to Venous Thromboembolism Risk in Women with Physical Disability in Pregnancy – Multidisciplinary Survey

S. Kazi¹, A. McLeod², A. Berndl³
Abstract Number: PB2485

Appropriateness of Direct Oral Anticoagulant Prescriptions in Emergency Department Outpatients with Acute Deep Vein Thrombosis

J. Tabah¹, C. Simard², V. Tagalakis³, M. Koolian³
Abstract Number: PB0535

APTT Clot Waveform Analysis: A Tool in Prediction of Pre-Analytical Errors in Short APTT- Retrospective Analysis

R. Phatale¹, S. Kannan², S. Apte²
Abstract Number: PB0702

APTT Mixing Studies in the Preoperative Setting

M. Nomdedeu¹, E. Cañamero², E. Sarrate³, M. Sorigue¹, J. Grau¹, A. Mesa¹, L. Ruiz⁴, F. Exposito⁵, M. Comes², A. Espasa², E. Orna¹, I. Hernandez¹, C. Morales⁵, T. Navarro¹
Abstract Number: PB0339

aPTT Reaction Curves Provide Important Additional Information in Hemophilia Patients

J. Pavic¹, M. Milos², D. Coen Herak², R. Zadro^2,3
Abstract Number: PB2112

Are Patients with an Active Cancer and those with a History of Cancer Carrying the Same Risks of Recurrent VTE and Bleeding while on Anticoagulants?

C. Frere^1,2, M. Lejeune¹, N. Janus³
Abstract Number: PB0219

Are the Plasma Levels Thresholds of DOAC Rationale and Appropriate for Clinical Decision-making? A Reappraisal Using Thrombin Generation Testing

J. Evrard¹, J.-M. Dogné^1,2, M. Hardy^3,4, S. Lessire³, V. Maloteau¹, L. Morimont^1,5, F. Mullier⁴, R. Siriez¹, J. Douxfils^1,5
Abstract Number: PB0244

Are Therapeutic Immunoglobulins Free from Factor XIa?

H. Wilmot, E. Gray
Abstract Number: PB2220

Are We Choosing Wisely? Heritable Thrombophilia (HT) Testing in a District General Hospital in the UK

L. Khalil
Abstract Number: PB1296

Arterial Ischemic Stroke in Greek Infants, Children and Adolescents: a Single-Centre Experience

A. Dettoraki¹, A. Michalopoulou¹, L. Ioannidou², A. Komitopoulou¹, M. Gavra³, P. Xafaki¹, Z. Kapsimali¹, H. Pergantou¹
Abstract Number: PB0642

Artificial Intelligence to Identify Neutrophil Extracellular Traps in Peripehral Blood Smears

K. Ikemura¹, M. Barouqa¹, K. Fedorov², M. Kushnir², H. Billett², M. Reyes-Gil¹
Abstract Number: PB1366

Artificial Neural Network for Prediction of Hemorrhagic Severity in Patients with Immune Thrombocytopenia Purpura

L.P. de Carvalho¹, M.P. Colella², J.M. Annichino-Bizzacchi³, T.D. Martins⁴
Abstract Number: PB1055

ASCVD Risk Score among Haemophilia Patients: Time to Formally Evaluate Cardiovascular Risk in People with Haemophilia

R. Camelo^1,2,3, B.P. Duarte², M.C.B. Moura², N.C.M. Costa², I.M. Costa², C.G.P. Roncal², A.M. Vanderlei², T.M.R. Guimaraes², C. Caram Deelder^3,4, S.C. Gouw³, S.M. Rezende¹, J.G. van der Bom^3,4
Abstract Number: PB2145

Aspects of Cancer-Related Venous Thrombosis in a cohort of 207 Tunisian Patients

M. Mama¹, F. Said¹, I. Naceur¹, H. Baccouche², I. Ben Ghorbel¹, M. Lamloum¹, M.H. Houman¹, N. Ben Romdhane²
Abstract Number: PB0060

Aspirin Antiplatelet Effects Are Associated with Body Weight

P. Mourikis¹, S. Zako¹, L. Dannenberg¹, C. Helten¹, D. Naguib¹, T. Hohlfeld², T. Petzold³, B. Levkau⁴, T. Zeus¹, M. Kelm¹, A. Polzin¹
Abstract Number: PB1150

Assay of Emicizumab Using the Modified One-Stage Clotting Assay

H. Wilmot, E. Gray
Abstract Number: PB1260

Assessing Anticipatory Guidance Needs in Adolescents with Bleeding Disorders

D. Cortes, J. Shao, M. Reyes
Abstract Number: PB1688

Assessing Platelet Function in Large Cohorts, a Means to Donor Stratification

J. Dunster¹, A. Bye², N. Kriek², T. Sage², C. Kempster², H. McKinney³, J. Batista³, P. Thomas³, W. Ouwehand³, K. Downes³, A. Unsworth⁴, J. Gibbins²
Abstract Number: PB0897

Assessing the Bleeding Phenotype in Non-Severe hemophilia by use of the ISTH Bleeding Assessment Tool (BAT)

F.R. Kloosterman¹, A. Zwagemaker¹, C.N. Bagot², E.A.M. Beckers³, J.G. van der Bom⁴, P. Collins⁵, M.H. Cnossen⁶, M. Coppens⁷, S.C. Gouw^1,4, B.A.P. Laros-van Gorkum⁸, S. Mangles⁹, F.J.M. van der Meer¹⁰, K. Meijer¹¹, L. Nieuwenhuizen¹², R. Schutgens¹³, K. Fijnvandraat¹
Abstract Number: PB0605

Assessing the Effect of Freezing and Thawing of Samples for Anti-Factor Xa Testing for the Determination of Enoxaparin Activity

S. Louw^1,2, R. Gounden^1,2, E.S. Mayne^2,3, J. Vaughan^1,2
Abstract Number: PB0050

Assessing the Impact of Switching to the Tobacco Heating System on Cardiovascular Disease: Translating Basic Science into Clinical Benefit

C. Pater, G. Baker, G. de la Bourdonnaye, A. Elamin, C. Goujon, C. Haziza, A. Heremans, J. Hoeng, N. Ivanov, F. Luedicke, S. Maeder, B. Philips, P. Picavet, S. Pouly, C. Poussin, P. Pratte, C.T. Tran, P. Vanscheeuwijck, M. Peitsch
Abstract Number: PB0534

Assessing the Quality of Interpretative Comments for Prolonged Activated Partial Thromboplastin Time and Mixing Tests

J.M. Bauça, É. Ajzner, J. Cadamuro, A. Hillarp, A.H. Kristoffersen, P. Meijer
Abstract Number: PB1904

Assessment and Comparison of Acquired Activated Protein C Resistance with Two Thrombin Generation Methods, CAT and ST-Genesia, in APS and SLE Patients

P.J. Lane¹, I. Mackie¹, D. Isenberg^2,3, H. Cohen^1,4, M. Efthymiou¹
Abstract Number: PB2057

Assessment and Predictors of Inappropriate Dose of Direct Oral Anticoagulants

M. Almegren¹, M. Alotaibi², M. Alghafis², M. Al-Alwan², S. Alshehri², M. Almulla², L. Zaid²
Abstract Number: PB0279

Assessment of Coagulation Factor Levels in LVAD Patients Following Temporary Warfarin Reversal with 4F-PCC (KVAD Study)

J. Rimsans¹, K.W. Sylvester¹, L. Coakley², E. Matiello-Lyons², K. Frankel², M. Hickey², F. Melanson², M.M. Givertz², J.M. Connors³
Abstract Number: PB2545

Assessment of Endocan as a Marker for Preeclampsia and Its Clinical Forms

A. Lopes¹, L. Dusse², S. Martins¹, M. Carvalho³, P. Alpoim¹
Abstract Number: PB0599

Assessment of ExpertCor, a New Set of Frozen Plasmas for Assay Comparability Studies

D. Yirga¹, J.-B. Baudier², A. Carlo³, P. Bourgeat²
Abstract Number: PB2188

Assessment of Fibrinolysis Markers in Patients with Lower Limb Deep Venous Thrombosis: A Prospective Case-control Study

S. Sharma¹, V. Uppal², N. Kumar², H. Renee², J. Ahluwalia², R. Das², N. Varma², P. Malhotra²
Abstract Number: PB0236

Assessment of Four Factor Prothrombin Complex Concentrate (4F-PCC) Usage in Emergency Department Patients: A Single Center Experience

H. McRae, F. Kara, R. Baum, N. Acquisto, M. Refaai
Abstract Number: PB0712

Assessment of in vitro Effects of Direct Thrombin Inhibitors on Activation of Coagulation Factor XIII through Enzyme Kinetics in the Synthetic Substrate-Based Assay

Y. Fujimori¹, M. Wakui², S. Nakamura³, Y. Kondo³, Y. Ozaki³, S. Oka³, T. Nakagawa³, H. Katagiri³, M. Murata²
Abstract Number: PB1481

Assessment of Platelet Function after Shear Stress Simulation Using an ex vivo Model for Extracorporeal Circulation

O. Hidiatov¹, I. Marini¹, L. Pelzl¹, F. Rigoni¹, M. Wagner¹, A. Straub², T. Bakchoul^1,3
Abstract Number: PB2561

Assessment of Post-partum Haemorrhage Risk among Women with Thrombocytopenia: A Cohort Study

S. Arcudi¹, A. Ronchi², M.W. Ossola², E. Iurlaro², M. Capecchi^3,4, A. Artoni³, F. Peyvandi^1,3
Abstract Number: PB2214

Assessment of Radiological Signs of Chronic Thromboembolic Pulmonary Hypertension on CTPAs Performed for Acute Pulmonary Embolism Leads to Earlier Diagnosis of CTEPH

G.J.A.M. Boon¹, P.M. Jairam², G.M.C. Groot³, C.J. van Rooden⁴, Y.M. Ende-Verhaar¹, L.F. Beenen⁵, L.J.M. Kroft⁶, H.J. Bogaard⁷, M.V. Huisman¹, P. Symersky⁸, A. Vonk Noordegraaf⁷, L.J. Meijboom⁵, F.A. Klok¹
Abstract Number: PB0609

Assessment of the CN-6000; a Novel, High-Speed Coagulation Analyser, Utilising Coagulation, Chromogenic, Immuno-Turdibimetric and Light Transmission Aggregation Technologies

A. Woolley¹, S. Kitchen¹, I. Patel², R. Wardle¹
Abstract Number: PB0303

Assessment of the Difference Between EXTEM and FIBTEM Amplitudes (PLTEM) and Their Correlation with Platelet Count (PLT), and the Effect of Fibrinogen and Hematocrit (HTC) in Cardiovascular Surgery (CVS)

M.S. López^1,2, F.G. Mileo³, L.H. Barrera^1,4, J. Oyhamburu^2,5, M.E. Martinuzzo^2,5
Abstract Number: PB1408

Assessment of the Hemostatic System by Total Thrombus-formation Analysis System (T-TAS) in Patients with Chronic Coronary Syndromes

O. Sirotkina^1,2, I. Nazarova¹, O. Melnichnikova¹, A. Panov¹, T. Vavilova¹
Abstract Number: PB2121

Assessment of the Ottawa Score in the Prediction of Recurrent Venous Thromboembolism in Patients Treated for Lymphoma

J. Rupa-Matysek¹, A. Hoppe¹, M.M. Joks², M. Joks¹, L. Gil¹
Abstract Number: PB1653

Assessment of Thrombus Formation under Flow-Conditions in Essential Thrombocythemia/ Polycythemia Vera

Y. Ikeda¹, T. Hato¹, A. Watanabe², J. Yamanouchi¹, K. Takenaka¹
Abstract Number: PB1109

Assessment of Vector Integration of AAV5-hFIX in Mice and Non-human Primates Indicates No Association with Tumorigenic Risk

L. Spronck, M. de Haan, L. Heijink, J. Twisk, V. Ferreira, S. van Deventer
Abstract Number: PB1256

Assessment of Vitamin K Level in Newborn Presenting with Bleeding in Population of Rural Sindh, Pakistan

N. Hafeez¹, I. Ujjan¹, S. Tabassum¹, K. Aamir¹, A. Naz²
Abstract Number: PB1012

Association Between Aging and Health Status in Persons Leaving with Hemophilia and Controls Without a Bleeding Disorder – Insights from the PROBE Study

F. Germini^1,2, S. O'Callaghan³, C. Chai-Adisaksopha^2,4, R. Curtis⁵, N. Frick⁶, M. Nichol⁷, D. Noone^8,9, B. O'Mahony¹⁰, D. Page¹¹, J. Stonebraker¹², M. Skinner^1,13, A. Iorio^1,14, PROBE investigators
Abstract Number: PB2461

Association Between Index VTE Event and 12-Months Outcomes for Patients in Routine Clinical Practice Enrolled in the ETNA-VTE-Europe Registry

M. Coppens¹, A.T. Cohen², C. Ay³, P. Hainaut⁴, U. Hoffmann⁵, S. Gaine⁶, D. Jiménez⁷, M. Schindewolf⁸, B. Brüggenjürgen⁹, P. Levy¹⁰, J. López Bastida¹¹, E. Vicaut¹², P. Bramlage¹³, G. Agnelli¹⁴, ETNA-VTE-Europe Investigators
Abstract Number: OC 10.1

Association between Initial and Residual Pulmonary Vascular Obstruction and Venous Thromboembolism Recurrence, a Pooled Analysis

R. Chaux¹, O. Sanchez^2,3, F. Couturaud^2,4, N. Meneveau⁵, E. Presles^1,6,7, R. Chopard⁵, L. Bertoletti^6,7,8, P. Mismetti^2,6,8, S. Laporte^1,7,9, E. Ollier^1,7
Abstract Number: PB1056

Association between Platelet Glycoprotein Common SNVs and Bleeding Severity in Haemophilia Patients

L. Bury¹, G. Piroli¹, H. Kuchi Bhotla¹, M. Borghi¹, E. Cesari¹, E. Falcinelli¹, R. De Cristofaro^2,3, B. Zieger⁴, P. Gresele¹
Abstract Number: PB0825

Association of Adherence and Bleeding Frequency among Severe Hemophilia A Patients on Prophylactic Factor VIII

F. Mohd Mokhtar^1,2, J. Sathar³, P.C. Bee⁴, H. Zaman Huri⁵
Abstract Number: PB2080

Association of Body Mass Index (BMI) with Bleeding Events in Patients Taking Oral Anticoagulation for Atrial Fibrillation (AF) or Venous Thromboembolism (VTE)

T. Feldeisen¹, X. Kong¹, E. Kline-Rogers¹, C. Alexandris-Souphis¹, B. Haymart¹, D. DeCamillo¹, S. Kaatz², M. Ali³, J. Kozlowski⁴, V. Shah⁵, G.D. Barnes¹, J.B. Froehlich¹
Abstract Number: PB2060

Association of Clinical Risk Factors and Biomarkers with Thromboembolism, Major Bleeding, and All-Cause Death in Patients with Atrial Fibrillation in a Tertiary Care Setting

D. Kraemmer, O. Königsbrügge, S. Nopp, I. Pabinger, C. Ay
Abstract Number: PB1515

Association of Genetic Variability in Selected Genes in Patients with Deep Vein Thrombosis and Platelet Hyperaggregability

L. Lisá, J. Sokol, J. Ivanková, J. Zolkova, L. Vadelova, I. Plamenova, J. Stasko
Abstract Number: PB0028

Association of MMP-12 and SDF1 with Symptomatic and Asymptomatic Atherosclerosis

M. Marcos Jubilar¹, J.C. Pastrana², J. Orbe^3,4,5, C. Roncal^3,4,5, J.A. Rodriguez^3,4,5, A. Fernández-Montero⁶, R. Rodil⁷, I. Colina⁸, J.A. Páramo^1,4,5
Abstract Number: PB1885

Association of Plasmic Score with Neurological Symptoms in Patients with Thrombotic Thrombocytopenic Purpura (TTP)

J.T.d.S. Castro¹, B.D.M. Mazetto², A.P. Rosa², G. Yamagutti³, M. Colella³, E.V. Paulo³, J.A. Bizachi³, F. Reis¹, F.A. Orsi³
Abstract Number: PB1621

Association of Platelet Derived – Microparticles and Endothelia Dysfunction in NVAF Patients Undertaking PCI

B. Ding¹, L. He², Y. Zhou¹
Abstract Number: PB2251

Association of Portal Vein Thrombosis and Clinical Outcomes in Cirrhotic Patients: A Nested Case-Control Study

P. Tavornshevin, A. Leerapun, E. Rattarittamrong, L. Norrasethada, P. Piriyakhuntorn, S. Hantrakool, A. Tantiworawit, T. Rattanathammethee, C. Chai-Adisaksopha
Abstract Number: PB2333

Association of Surgical and Medical Hospitalizations with Venous Thromboembolism (VTE) in a Primary Care Population

X. Jordan Bruno¹, I. Koh², T.B. Plante³, C.E. Holmes⁴, R. Walker⁵, P. Lutsey⁶, A.B. Repp⁷, M. Cushman⁸, N.A. Zakai⁹
Abstract Number: PB0943

Associations between Physical Activity Levels and Bleeding Frequency in People with Mild, Moderate, and Severe Hemophilia A (HA): A Preliminary Analysis of the CHESS II Study

F. Nissen¹, T. Burke², S. Asghar², A. Shang¹, M. Aizenas¹, O. Meier¹, J. O'Hara^2,3
Abstract Number: PB1984

Astrocytes Are Central Contributors in Restoration of the Blood Brain Barrier via Transcriptional Upregulation of Key Gap Junction Proteins between Endothelial Cells

P. Stafford¹, S. Mitra¹, A. Stem¹, P. Lutz¹, J. Hadley¹, A. D'Alessandro², K. Jones³, C. Silliman⁴, E. Moore¹, M. Cohen¹
Abstract Number: PB1266

Asymptomatic Catheter Related Thrombosis in Neonates: The Role of Thrombophilia Testing

B. Allahyani^1,2, A. Lesleigh¹, R. Ljung²
Abstract Number: PB1018

ATHN 7: A Natural History Cohort Study of the Safety, Effectiveness, and Practice of Treatment for People with Hemophilia-Demographics and Preliminary Results

T. Buckner¹, N. Daoud², S.E. Croteau³, C.L. Kempton⁴, L. Malec⁵, J. Staber⁶, M. Wang¹, C. Watson², M. Recht²
Abstract Number: PB1331

Atorvastatin Restores the Imbalance of CD4⁺ T cells in Immune Thrombocytopenia via Ras/MEK/ERK and mTOR/PI3K/AKT Pathways

P. Xu¹, M. Xu², M. Hou²
Abstract Number: PB2088

Atrial Fibrillation Treated with Warfarin at an Academic Medical Center: The Potential Impact of Direct Oral Anticoagulants on Future Management

P. Collins¹, A. Lewin¹, N. Vincze Irving¹, K. Sylvester¹, J. Fanikos¹, S.Z. Goldhaber², J.M. Connors³
Abstract Number: PB1605

Autoantibody Mediated Changes in Megakaryocytes Glycan Pattern: Potential Impact on Thrombopoiesis in Immune Thrombocytopenia

I. Marini¹, J. Zlamal¹, L. Pelzl¹, K. Althaus^1,2, T. Bakchoul^1,2
Abstract Number: PB0782

Autoimmune Acquired Factor XIII Deficiency: A Case Report

A. Marco^1,2, A. Garzo^1,2, E. Campos^1,2, L. Tomas^1,2, P. Marco^1,2,3
Abstract Number: PB1414

Autoimmune Heparin-Induced Thrombocytopenia Successfully Treated using Direct Oral Anticoagulant and Intra-Venous Immunoglobulin

E.-M. Walle¹, O. Chassin², N. Legris², N. Chanson³, V. Proulle¹
Abstract Number: PB1862

Automated Chemiluminescent ADAMTS13 Activity Immunoassay for Thrombotic Thrombocytopenic Purpura Diagnosis and Follow-up

N. Beranger^1,2, S. Benghezal^1,2, B. Joly^1,2, S. Capdenat^1,2, A. Delton^1,2, A. Stepanian^1,2, P. Coppo³, A. Veyradier^1,2