ISTH 2020 Congress Archives - ISTH Congress Abstracts

Abstract Number: PB2287

D-dimer Diagnostics: An International Assessment of the Quality of Laboratory Testing

C. Elbaz¹, P. Meijer², M. van Essen-Hollestelle², Z. Liederman¹, R. Selby^1,3
Abstract Number: PB2261

D-Dimer is Useful in the Assessment of Suspected Recurrent Venous Thromboembolism in Patients on Rivaroxaban or Apixaban

H.L.A. Yuen^1,2, E. Malan¹, J. Clifford¹, A. Bennett¹, A. So¹, P. Leung¹, S. Chunilal^1,2
Abstract Number: PB2277

D-Dimer Plasma Levels and the Anatomical Extension of Acute Symptomatic Deep Vein Thrombosis of the Lower Limbs

B. Cosmi¹, C. Legnani², M. Cini², G. Guazzaloca¹, G. Rodorigo¹, M. Sartori¹, G. Palareti²
Abstract Number: PB2516

D-Dimer Variability in the Postpartum Period

T. Malinova, D. Stambolieva, S. Ortakovska
Abstract Number: PB0993

Data Mining: An Innovative Approach to Optimise Post-Hoc Analyses of Large Trial Data Sets into Clinically Relevant Results

P. Chowdary¹, S. Benchikh El Fegoun², M.S. Geybels³, A. Tiede⁴
Abstract Number: OC 03.3

Deciphering the Ets-1/2-mediated Transcriptional Regulation of F8 Gene Identifies a Minimal F8 Promoter for Hemophilia A Gene Therapy

R. Famà¹, E. Borroni¹, S. Merlin¹, S. Pignani¹, C. Airoldi², A. Cucci¹, V. Bruscaggin¹, S. Scardellato¹, M. Pinotti³, G.E. Walker¹, A. Follenzi¹
Abstract Number: PB0487

Deciphering the Protein Secretome of Leukocyte-platelet Rich Fibrin

L. Hermida Nogueira¹, M.N. Barrachina¹, L.A. Morán¹, S. Bravo², P. Diz³, J. Blanco³, Á. García¹
Abstract Number: PB2199

Decreased Expression of Annexin A2 Is Associated with Reduced Cell Surface Fibrinolysis and Venous Thromboembolism

K. Hajjar, H. Fassel, H. Chen, M. Ruisi, N. Kumar, M. De Sancho
Abstract Number: PB0846

Decreased Platelet Surface Phosphatidylserine Predicts Increased Bleeding in Patients with Severe Factor VIII Deficiency

A.L. Frelinger III^1,2, S.E. Croteau^2,3, A.J. Gerrits^1,2, A.D. Michelson^1,2
Abstract Number: PB2147

Decreased Thrombin Generation Potential in Lymphoma Patients Is Associated with Increased D-dimer, CRP, vWF and TNF-α. Interrelationship between Thrombogenesis and Inflammation

F. Siddiqui¹, E. Bontekoe¹, D. Antic², D. Hoppensteadt¹, G. Gerotziafas³, J. Fareed¹
Abstract Number: PB0748

Deep Mutational Scanning and High-Throughput Kinetics to Quantitatively Assess Plasminogen Activator Inhibitor-1 Variants

L.M. Haynes¹, Z.M. Huttinger¹, D. Ginsburg^1,2
Abstract Number: PB0215

Deep Vein Thrombosis and Coagulation Factor Deficiency: A Paradoxical Association

Y. Cherif, M. Mrouki, R. Ghariani, S. Derbel, F. Ben Dahmen, M. Abdallah
Abstract Number: PB2238

Deep Vein Thrombosis Associated with Protein S Deficiency

P. Romadhon, M. Savitri, P. Niken, U. Bintoro, M. Sedana, A. Ashariati
Abstract Number: PB2144

Deep Venous Thrombosis and Intraductal Papillary and Mucinous Tumor of the Pancreas: about 3 Cases

Y. Cherif¹, R. Ghariani², M. Mrouki¹, S. Derbal¹, F. Ben Dahmen¹, M. Abdallah¹
Abstract Number: PB2304

Deep Venous Thrombosis with Atypical Location: About 22 Cases

S. Derbal, Y. Cherif, F. Ben Dahmen, M. Abdallah
Abstract Number: PB1488

Defective Endocytosis of Albumin, Fibrinogen and IgG in Platelets with RUNX1 Haplodeficiency

F. Del Carpio-Cano¹, G. Mao², L. Goldfinger³, J. Wurtzel³, A.K. Rao¹
Abstract Number: PB1502

Defective RAB31-mediated Endosomal Trafficking in RUNX1 Haplodeficiency

G. Jalagadugula¹, G. Mao¹, L. Goldfinger², J. Wurtzel², M. Lambert³, A.K. Rao¹
Abstract Number: PB1996

Defibrotide Prevents Sepsis Induced Endothelial Cell Activation

M. Palomo¹, S. Fernandez², P. Molina³, J. Aibar², J. Nicolas², P. Castro², M. Diaz-Ricart³
Abstract Number: PB0473

Defining Acetylsalicylic Acid Responsiveness: Understanding the Relation between Thromboxane B₂Inhibition and Aggregation Induced by Arachidonic Acid

K. Bliden¹, U. Tantry¹, G. Ens², W. Messbarger², R. Chaudhary³, P. Gurbel⁴
Abstract Number: PB1848

Defining the Effects of Storage Lesion on Platelet Autophagic Activity

S. Fauteux-Daniel^1,2, E. Audoux², J. Fagan^1,2, H. Hamzeh-Cognasse², M.-A. Eyraud^1,2, C.-A. Arthaud^1,2, O. Garraud^2,3, A. Bernard¹, P. Verhoeven^2,4, S. Laradi^1,2, F. Cognasse^1,2
Abstract Number: PB1582

Degradation of High Molecular Weight von Willebrand Factor Multimers during Extracorporeal Membrane Oxygenation-Treatment

M.-S. Kim¹, C.-J. Park¹, S. Jang¹, Y.-U. Cho¹, S.-B. Hong²
Abstract Number: PB0278

Delay in Time to Hip Fracture Repair Surgery among Elderly Patients Treated with Anti Platelet Therapy

A. Lubetsky^1,2, A. Seltser^2,3
Abstract Number: PB2402

Demographics and Clinical Outcomes of Older Adults Treated for Acute Venous Thromboembolism

R. Chaudhary¹, D.T. Vlazny², A.I. Casanegra², D.E. Houghton², D.A. Froehling², L.G. Peterson², D.O. Hodge³, R.D. McBane II², W.E. Wysokinski²
Abstract Number: PB2400

Demographics and Clinical Outcomes of Patients Younger than 40 Years Treated for Acute Venous Thromboembolism

D.T. Vlazny¹, W. Wysokinski¹, D.E. Houghton¹, D.O. Hodge², D.A. Froehling¹, L.G. Peterson¹, A.I. Casanegra¹
Abstract Number: PB1992

Design and Characterization of Novel Activated Protein C (APC) Variants for the Proteolysis of Cytotoxic Extracellular Histone H3

J. Huckriede, D. Beurskens, K. Wichapong, K. Wildhagen, T. Hackeng, C. Reutelingsperger, G. Nicoleas
Abstract Number: PB1157

Design of a Novel Factor IX Albumin Fusion Protein with Enhanced Coagulant Activity and Pharmacokinetic Profile

S. Lombardi¹, J. Nilsen^2,3, K. Hovden Aaen^2,3, M. Ferrarese¹, M. Pinotti¹, M. Bern^2,3, D.C. Roopenian⁴, I. Sandlie^2,5, J.T. Andersen^2,3, A. Branchini¹
Abstract Number: PB0259

Design of Polyphosphate Inhibitors that Reduce Thrombosis without Increased Bleeding

C.C. La^1,2, S.A. Smith³, M.D.G. Jaraquemada-Peláez^1,2, S. Abbina^1,4, L.A. Creagh⁵, C.A. Haynes⁵, J.H. Morrissey³, J.N. Kizhakkedathu^1,2,4
Abstract Number: PB1330

Desmopressin for Procedures or Radiological Interventions (DRIVE): Participant Characteristics in a Placebo-Controlled Double-Blind, Randomised Feasibility Trial of Desmopressin in Thrombocytopenic Critically Ill Patients Prior to Procedures

M. Desborough¹, E. Laing², A. Griffiths³, A. Mora², R. Hodge², S. Martin², A. Shah⁴, P. Hutton⁵, T. Parke⁶, M. Wise⁷, M. Morgan⁷, S. McKechnie⁵, S. Stanworth^4,8, DRIVE Trial Investigators
Abstract Number: PB1390

Desmopressin for Reversal of Antiplatelet Drugs in Stroke due to Haemorrhage (DASH): Interim Report on Recruitment from a Phase II Double Blind Randomised Controlled Trial

M. Desborough¹, R. Al-Shahi Salman², S. Stanworth^3,4, D. Havard⁵, P.M. Brennan², R. Dineen⁵, T. Coats⁶, P. Johnson⁷, T. Hepburn⁸, P. Bath⁵, N. Sprigg⁵, DASH Trial Investigators
Abstract Number: PB1579

Desmopressin in Patients with Type 2B von Willebrand Disease: Differential Impact on VWF and Platelet Function

A. Dupont^1,2, A. Rauch^1,2, C. Paris^1,2, F. Lassalle^1,2, A. Hochart^1,2, B. Wibaut^1,2, A. Bauters^1,2, J. Goudemand^1,2, C. Zawadzki^1,2, E. Jeanpierre^1,2, S. Susen^1,2
Abstract Number: PB1133

Desmopressin Response and Clinical Outcome in Bleeding Disorders: A 30 Year Retrospective Analysis

M.R. Peralta¹, B. Gration¹, A. Agapidou², C.D. Garcia¹, T.T. Yee¹, A. Riddell¹, K. Gomez¹, Z. Hanif¹, A. Drebes¹, C. Hamid¹, P. Morjaria¹, E. Aradom¹, D. Pollard¹, P. Chowdary¹
Abstract Number: PB0893

Detectability and Clinical Significance of Calcium Exchange and 25 (OH) D in the Development of Osteoporosis in Patients with Hemophilia

N. Akhrarova, A. Makhmudova, L. Ashurova, O. Madasheva
Abstract Number: PB0246

Detecting Oral Kallikrein-Targeting Therapy through Triggered Contact Activation: A Phase I Study

C. Clark¹, Z.L.M. Hofman^1,2, C.E. Hack², S. de Maat¹, C. Maas¹
Abstract Number: PB0344

Detection and Quantification of F8 Inv1 and Inv22 Inversions Using Digital Droplet PCR and Mile-post Assays

E. Manderstedt¹, C. Lind-Halldén¹, A. Lidén¹, R. Ljung², J. Astermark², C. Halldén¹
Abstract Number: PB1393

Detection of Clopidogrel Resistance: Comparison of Light Transmission Aggregometry and INNOVANCE® PFA P2Y Cartridge and Correlation with CYP2C19 Variants

L. Heireman, K. Devreese
Abstract Number: PB2292

Detection of MicroRNA-126 as a Plasma Biomarker for Diagnosis of DVT

X. Bai, J. Su, Y. Zhao, W. Zhang, C. Ruan
Abstract Number: PB1423

Detection of Pathogenic Anti-platelet Factor 4 Antibodies by Impedance Spectroscopy

N.Z. Khan¹, D. Frense², A. Lindenbauer¹, T.-H. Nguyen¹
Abstract Number: PB0829

Detection of Residual Factor VIII Levels Reveals the Occurrence of Readthrough Over the Majority of F8 Nonsense Mutations

M.F. Testa¹, S. Lombardi¹, M. Ferrarese¹, M. Pinotti¹, G. Castaman², P. Radossi³, D. Belvini⁴, F. Bernardi¹, A. Branchini¹
Abstract Number: PB2014

Determinants of Neutrophil Extracellular Trap Formation in the General Population: Based on the Rotterdam Study Cohort

S.J. Donkel¹, F.J. Wolters², M.A. Ikram², M.P.M. de Maat¹
Abstract Number: PB0676

Determination of Serotonin Concentration in Single Human Platelets by Single-entity Electrochemistry

J. Lee¹, Y. Kang¹, J. Chang², J. Song³, B.-K. Kim¹
Abstract Number: PB1445

Determination of the Genotype of von Willebrand Disease Type 3

D. Provazníková¹, F. Mareček¹, F. Oyen², V. Geierová³, J. Loužil³, A. Radovská¹, M. Šimoníková¹, R. Schneppenheim², P. Salaj³, I. Hrachovinová¹
Abstract Number: PB2290

Determining Predictive Factors of Venous Thromboembolism Using Design of Experiments

G.Y. Ottaiano¹, J.M. Annichino-Bizzacchi², R. Maciel-Filho³, T.D. Martins¹
Abstract Number: PB1149

Determining the Approximate Factor VIII Level Equivalency of Patients with Severe Hemophilia A on Emicizumab Using Global Hemostasis Assays

H. Kizilocak¹, E. Marquez-Casas¹, J. Malvar¹, R. Carmona¹, G. Young^1,2
Abstract Number: PB1152

Determining the Optimal Method for FVIII:C and Anti-FVIII Quantification in a Patient Treated with Adynovi^® who Developed Anti-FVIII during Treatment

L. Heireman, K. Devreese
Abstract Number: PB2169

Developing an ex vivo Method to Study Thrombosis in Cancer Patients: Cancer-associated Thrombosis-on-a-Chip

A.M.R. Rondon¹, E.H. Laghmani¹, W. Stam², V. van Duinen², K. Queiroz³, P. Vulto³, A.J. van Zonneveld², H. Versteeg¹
Abstract Number: PB2299

Developing Fluidic Models that Replicate Cephalic Arch Geometry and Flow Conditions of Dialysis Patients to Understand and Predict Access Thrombosis

A. Moya Rodriguez¹, C. Bernstein², B. Xie², M. Hammes³, A. Basu²
Abstract Number: PB0122

Developing of a New Animal Artery Model of Atherothrombotic Stenosis using Perivascular Monopolar High-Frequency Electrical Current-Mediated Endothelial Injury Followed by a Cholesterol-Rich Diet Injury and Finally Perivascular Severe Cold Injury using Liquid Nitrogen

H. Mehrad¹, M. Farhoudi²
Abstract Number: PB2496

Development and External Validation of a Risk Assessment Model for First Venous Thromboembolism in Women Starting Combined Oral Contraceptives

D.K. Khialani¹, S. Arcudi², S. Cannegieter¹, A. van Hylckama Vlieg¹
Abstract Number: PB0350

Development and Performance Characterization of an Automated Chromogenic Assay for Human Factor IX Activity

N. Ramamurthy, S. Duffin, C. Kucharski, Z. Vandertuin, S. Kaushik, M. Morris
Abstract Number: PB1871

Development and Validation of a Prediction Model (AHC) for Early Identification of Refractory Thrombotic Thrombocytopenic Purpura Using Nationally Representative Data

Q.-S. Huang^1,2,3, R.-Y. Gui^1,2,3, Y. Liu⁴, H. Liu⁵, M.-Y. Fang⁶, L.-H. Yang⁷, J.-Y. Zhang⁸, Y.-F. Cheng⁹, M. Jiang¹⁰, M. Mao¹¹, L.-R. Wang¹², Z. Wang¹³, H.-B. Zhou¹⁴, H. Lan¹⁵, Z.-X. Jiang¹⁶, X.-L. Shen¹⁷, L. Zhang¹⁸, S.-J. Fan¹⁹, X.-J. Huang^1,2,3, X.-H. Zhang^1,2,3
Abstract Number: PB0119

Development of a Clinical Cohort of HIV-infected Patients with Peripheral Vascular Disease

E. Mayne¹, A.T.O. Abdool-Carim², T.T. Monareng², N. Funderburg³, W.S. Stevens^4,5, M. Lederman⁶, S. Louw^5,7
Abstract Number: PB0678

Development of a Flow Cytometry-based Assay for the Detection of ITP Autoantibodies

M. Neves^1,2, A. Arad³, Y. Wang¹, G. Zhu¹, R. Galant¹, M. Thompson⁴, H. Ni^1,2
Abstract Number: PB0527

Development of a Logistic Regression Model for Prediction of Conversion Risk from Mild Cognitive Impairment (MCI) to Alzheimer´s Disease (AD)

G.S. Gonçalves¹, M.A. Bicalho², M.T. Cintra², C. Moreira³, R.C. Duarte¹, E. Reis³, D.R. Rios⁴, L.M. Dusse¹, K.B. Borges¹, M.D.G. Carvalho¹
Abstract Number: PB0468

Development of a Microfluidic Pillar Device to Study Hemostasis in vitro

H.H.S. Lakshmanan¹, A. Pore², J.J. Shatzel¹, P. Cristina¹, P. Jurney³, J. Maddala⁴, S.A. Vanapalli², O.J.T. McCarty¹
Abstract Number: PB1966

Development of a Novel Mouse Model of Abdominal Aortic Aneurysm with Intraluminal Thrombus

K. Yahiaoui¹, C. Herbet¹, R. Martos¹, H. Lebas¹, B. Ho Tin Noe¹, W. Bergemeier², P. Conley³, E. Camerer⁴, M.C. Bouton¹, Y. Boulaftali¹
Abstract Number: PB0497

Development of an Accessible Open Source Code in Python for High-Resolution Melting Data Analysis from Patients Diagnosed with Hemophilia A in Bogotá, Colombia

J. Lago¹, D.L. Navas¹, P.A. Lago², M.C. Gamboa³, D.C. Polanía¹, H. Groot¹
Abstract Number: PB2425

Development of Cyclic Peptide Inhibitors of Coagulation Factor XIa for Safer Anticoagulation

V. Carle¹, Y.T. Wu¹, R. Mukherjee¹, X.-D. Kong¹, J. Goto², B. Stegmayr², C. Heinis¹
Abstract Number: PB2100

Development of Predictive Score for Venous Thromboembolism in Hematologic Malignancies

A. López Sacerio¹, S. Rendón Peralta², E. Barreto Fiu³, N. Alvarez Basulto⁴, M. Acosta Alvarez¹
Abstract Number: PB2534

Deviations in Red Blood Cell Gas Transport Function in Pregnant State

E. Iastrebova^1,2, E. Kolegina¹, V. Maltsev^1,2
Abstract Number: PB0030

Diabetes Mellitus and Risk of Intracranial Atherosclerosis: A Meta-Analysis Using Real-World Evidence

S. Hussain¹, A.K. Najmi²
Abstract Number: PB2011

Diabetes Mellitus Increases Thrombin and Activated Protein C Effects on Mast Cell and Macrophages

L. Gorbacheva^1,2, E. Kiseleva³, I. Goliako¹
Abstract Number: PB0507

Diagnosing and Categorizing Acquired Fibrinolysis Activity with Global Hemostatic Assays

G. Mohan, S. Shastry, P.A. Prethika, D. Kandasamy
Abstract Number: PB2267

Diagnosing Deep Vein Thrombosis in Patients with Suspected Symptoms and a Concurrent Malignancy: An Individual Participant Data Meta-Analysis

T. Takada¹, S. van Doorn¹, S. Parpia², K. de Wit³, D. R. Anderson⁴, S. M. Stevens^5,6, S. C. Woller^5,6, A.J. ten Cate-Hoek⁷, J. L. Elf⁸, R. A. Kraaijenhagen⁹, R. E.G. Schutgens¹⁰, P. S. Wells¹¹, C. Kearon³, K. G. M. Moons¹, G.-J. Geersing¹
Abstract Number: PB0786

Diagnosis and Management of Acquired Von Willebrand Disease in Two Italian Centers

A. Ferretti¹, E. Baldacci¹, M. Basso², R. Abbruzzese¹, M.L. De Luca¹, F. Barone¹, R. Bochicchio¹, A. Chistolini¹, M.G. Mazzucconi¹, E. De Candia³, C. Santoro¹
Abstract Number: PB0824

Diagnosis and Management of Acute Hemarthrosis and Haemophilic Arthropathy in Spain Using Unified Clinical and Ultrasound Criteria: Preliminary Results

A. Chimeno Hernandez¹, S. Pérez-Alenda^2,3, J.J. Carrasco^2,4, M. Aguilar^3,5, S. Haya³, A.R. Cid³, J.E. Megías⁶, S. Bonanad³, F. Querol^2,3
Abstract Number: PB1590

Diagnosis and Management of von Willebrand Disease in a Portuguese Reference Center of Congenital Coagulopathies

C. Catarino Oliveira¹, F. Rodrigues¹, A. Pereira¹, S. Campaniço¹, M. Teodoro¹, C. Silva Pinto², P. Martinho², T. Fidalgo²
Abstract Number: PB0362

Diagnosis and Treatment of Obstetrics Disseminated Intravascular Coagulation in Resource Limited Settings

H. Okoye¹, T. Nwagha¹, E. Ugwu², I. Menuba², A. Duru¹, A. Ugwu¹, I. Ezebialu³, S. Eze⁴, A. Ugwu⁵
Abstract Number: PB1437

Diagnosis of Inherited Platelet Disorders on a Blood Smear: The One-Year Experience of a Reference Laboratory

C. Zaninetti^1,2, M. Baschin², C. Freyer², A. Greinacher²
Abstract Number: PB1522

Diagnosis of von Willebrand Disease in Algeria Laboratory and Clinical phenotype: Single Center Experience

D. Benlaldj^1,2, M.A. Mouedene¹
Abstract Number: PB1435

Diagnostic Approach to Inherited Thrombocytopenias in a Low-Income Setting

A.C. Glembotsky^1,2, N.P. Goette¹, C.P. Marin Oyarzún^1,2, C. Baroni Pietto^1,2, D. Ayala^1,2, D. Altuna³, M.E. Arrieta⁴, N. Basak⁵, S. Bonacorso⁶, A. Brodsky⁶, H. Donato⁷, J.D. Korin⁸, P. Lagrotta⁹, F. Negro¹⁰, C. Ponzinibbio¹¹, E. Veber¹², A. Savoia^13,14, A. Pecci¹⁵, R.F. Marta^1,2, P.G. Heller^1,2
Abstract Number: PB0671

Diagnostic Performances Evaluation of LIAPHEN Free Protein S on CS-2500

C. Dunois¹, P. Gueret², R. Parage², A. Pontis², F. Nedelec², I. Gouin², J. Amiral¹
Abstract Number: PB1589

Diagnostic Performances Evaluation of LIAPHEN vWF: Ag on CS-2500

C. Dunois¹, P. Gueret², R. Parage², A. Pontis², F. Nedelec², I. Gouin², J. Amiral¹
Abstract Number: PB1664

Dietary Intake of Zinc Modulates Platelet Intracellular Levels and Haemostatic Parameters

U. Sumya¹, C. Whyte¹, J. Beattie², F. Thies², N. Mutch¹
Abstract Number: PB0330

Difference Molecular Profiles of Type 1 and 2 Inhibitor Developed in Mild/Moderate Hemophilia A

S. Furukawa^1,2, K. Nogami¹, M. Shima^1,2
Abstract Number: PB/LB03

Differences in Outcomes between Real-World vs Clinical Trial in Atrial Fibrillation and Chronic Kidney Disease

W.Y. Ding¹, J.M.R. Caravaca^1,2, V. Roldán³, G.Y.H. Lip^1,4
Abstract Number: PB1003

Differences in Pharmacokinetic Evaluated by Clotting and Chromogenic Factor VIII Assays in Twelve Persons with Severe Hemophilia A on Prophylaxis with Recombinant Factor VIII Fc Fusion Protein (rFVIIIFc)

E. Cruz, M. Pereira, M. Coutinho, R. Matos, L. Moreira, S. Morais
Abstract Number: PB0845

Differences in the Prediction of the Time above Target in Hemophilia A Patients Using a Chromogenic Assay and a One-stage Assay in Model-informed Precision Dosing

D.W. Uster¹, C.D. Garcia², A. Riddell², E. Aradom², M. Musarara², C. Hamid², C. Tait³, S. Mangles⁴, N. Curry⁵, P. Chowdary², S.G. Wicha¹
Abstract Number: PB2051

Differences in Treatment and Outcomes in Recently Diagnosed Atrial Fibrillation between the Netherlands and Belgium: Results from the GARFIELD-AF Registry

J. Seelig^1,2, M.E.W. Hemels^1,3, O. Xhaët⁴, M.C.M. Bongaerts⁵, A. de Wolf⁶, B.E. Groenemeijer⁷, A. Heyse⁸, P. Hoogslag⁹, J. Voet¹⁰, J.P.R. Herrman¹¹, G. Vervoort¹², W. Hermans¹³, B. Wollaert¹⁴, L.V.A. Boersma^15,16, K. Hermans¹⁷, A. Lucassen¹⁸, K. Pieper¹⁹, F.W.A. Verheugt¹¹, F. Cools²⁰, H. ten Cate^2,21, on behalf of the GARFIELD-AF Investigators
Abstract Number: PB0753

Different Incorporation of Apha2-plasmin Inhibitor C-terminal Forms into the Fibrin Clot

B. Baráth, É. Katona
Abstract Number: PB2148

Differential Augmentation of Thrombin Generation by Andexanet Alfa in Lymphoma Patients

F. Siddiqui¹, D. Antic², E. Bontekoe¹, D. Hoppensteadt¹, N. Baig¹, G. Gerotziafas³, A. Tafur⁴, J. Fareed¹
Abstract Number: PB1857

Differential Diagnosis of Thrombotic Thrombocytopenic Purpura at Acute Phase by the Ratio of VWF Activity to VWF Antigen Based on Automatic Immunologic Assays

N. Tang
Abstract Number: PB2062

Differential Effect of Direct Oral Anticoagulants (DOACs) on Thrombin Generation and Clot Lysis in Patients with Non Valvular Atrial Fibrillation (AF) and Venous Thromboembolism (VTE)

L. Dirienzo¹, A. Vitulli¹, C.T. Ammollo¹, F. Mancazzo¹, C. Dellanoce², O. Paoletti², S. Testa², M. Colucci¹
Abstract Number: PB0009

Differential Effects of Clopidogrel with or without Aspirin on Platelet Reactivity and Coagulation Activation: A Randomized Placebo-Controlled Trial in Healthy Volunteers

L. Traby¹, M. Kollars¹, A. Kaider², J.M. Siller-Matula³, H.C. Puhr¹, O. Steinbrecher¹, L. Eischer¹, M. Wolzt⁴, P.A. Kyrle¹, S. Eichinger¹
Abstract Number: PB1939

Differential Expression of CD46 in Leukocytes by Flow Cytometry: Methodological Aspects

S. Rotondo¹, C. Dos Santos², M.F. Alberto¹, A. Sánchez-Luceros^1,2
Abstract Number: PB1970

Differential Expression of Inflammatory Mediators in Venous Tissue and Serum Suggest Natural Killer (NK) Cell-mediated Responses in Chronic Venous Insufficiency

U. Sachdev, L. Vodovotz, D. Barclay, J. Yin, R. Zamora, Y. Vodovotz
Abstract Number: PB2167

Differential Expression of Neutrophil Activation Markers in Venous Thromboembolism Patients with and without Association to Cancer

J. Oto¹, V. Sánchez-López², E. Arellano², T. Elias³, L. Jara², M.I. Asensio³, R. Otero³, P. Medina¹
Abstract Number: PB1735

Differential Regulation of the Platelet GPIb-IX Complex by Anti-GPIbβ Antibodies

M.E. Quach¹, W. Chen¹, Y. Wang¹, H. Deckmyn², F. Lanza³, B. Nieswandt⁴, R. Li¹
Abstract Number: PB0857

Differential Systemic Transcriptional Responses to Induced Joint Bleeding in Wild-type and Factor VIII-deficient Mice

E. Cooke, C. Nasamran, K. Fisch, A. von Drygalski
Abstract Number: PB2376

Dilemma in Initiating Thromboprophylaxis in Critically Ill Patients

P. Lasut, V. Irawan, R. Adiwinata, C. Kawengian, C. Hendratta, L. Rotty, H. Haroen
Abstract Number: PB0738

Dipicolinic Acid Produced by Fermentation (Bacillus subtilis natto)

H. Sumi¹, T. Mitsuo², H. Inoue³
Abstract Number: PB/CO01

Dipyridamole Added to Anticoagulant Prophylaxis: Decline in Poor Outcome of Clinically Severe Ill COVID-2019 Patients

S. Kalayoglu Besisik, M. Ozbalak, Y.B. Tor, A. Alibeyoglu, M. Kose, N. Şenkal, A. Cagatay, M. Erelel, A. Gul, F. Esen, S. Umman, U. Isoglu Alkoclar, T. Tukek
Abstract Number: PB2398

Direct Oral anti-Xa Inhibitors for Treatment of Venous Thromboembolism after Gastrectomy: Report on 3 Cases

L. Eischer¹, S. Eichinger¹, P. Quehenberger², P.A. Kylre¹
Abstract Number: PB2492

Direct Oral Anticoagulants and Antiepileptic Drugs: Is There Room for Concurrent Treatment?

S. Barbar¹, M. Simonetto², E. De Bon³, L. Scarano³, G. Caneve², N. Simioni³
Abstract Number: PB2414

Direct Oral Anticoagulants and Vitamin K Antagonists for Treatment of Cerebral Vein Thrombosis

M. Capecchi^1,2, M. Abbattista¹, F. Gianniello¹, A. Artoni¹, P. Bucciarelli¹, F. Peyvandi^1,3,4, I. Martinelli¹
Abstract Number: PB1128

Direct Oral Anticoagulants Bleeding Events in Patients with Atrial Fibrillation Vs Venous Thromboembolism Admitted to an Emergency Department: Real-Life Study

F. Moustafa^1,2, T. Fleuchot¹, D. Teissandier¹, J. Schmidt^1,2
Abstract Number: PB2465

Direct Oral Anticoagulants in Comparison with Vitamin K Antagonists and Antiplatelet Agents on Timing and Outcomes in Hip Fracture Surgery Patients Older than 75: The ORTHO-GER-DOAC Study

B. Cosmi¹, E. Martini², S. Sandri³, M.L. Lunardelli², F.L. Gorgoglione⁴, A. De Laurenzo⁵, E. Grandone⁵
Abstract Number: PB2161

Direct Oral Anticoagulants in Patients with Hematological Malignancies

A. Serrao¹, L. Fiori², C. Santoro³, M. Breccia², E. Baldacci³, M.L. De Luca², G. De Luca², F. Barone², A. Chistolini³
Abstract Number: PB2467

Direct Oral Anticoagulants in Patients with Severe Familial Thrombophilia

D. Tormene, C. Simion, M. Marobin, G. Turatti, A. Pontarin, E. Campello, P. Simioni
Abstract Number: PB1926

Direct Oral Anticoagulants versus Vitamin K Antagonists in Antiphospholipid Syndrome: A Meta-analysis

A. Iriarte Fuster¹, P. Cerdà Serra¹, J.M. Mora Luján¹, J. Cortés Hernandez², M. Llaberia Torrelles¹, K. Lopez Aldabe¹, X. Corbella Virós^1,3, C. Becattini⁴, A. Riera Mestre^1,5
Abstract Number: PB2484

Direct Oral Anticoagulants vs. Warfarin for the Treatment of Venous Thromboembolism in Patients with Thrombophilia. A Single Center Experience

S. Basaria, M. Elsebaie, J. Li, M. Gaddh
Abstract Number: PB1666

Direct Temporal Labelling of Platelets in vivo Allows Monitoring and Examination of Newly Formed and Aged Platelets to Reveal Changes in Receptor Expression Levels and Loss of Functional Ability

P. Armstrong¹, A. Joshi², M. Crescente¹, M. Mayr², T. Warner¹
Abstract Number: PB/CO06

Disantangling the Mechanisms behind the Thrombotic Complications of COVID-19 Patients: Insights into Platelet and Endothelial Activation

P. Canzano¹, M. Brambilla¹, E. Tortorici², N. Cosentino¹, B. Porro¹, M. Pengo², A. Bonomi¹, F. Veglia¹, G. Parati², V. Cavalca¹, E. Omodeosalè¹, E. Tremoli¹, M. Camera^1,3
Abstract Number: PB1402

Discontinuation of Chronic Low Dose Acetylsalicylic Acid Therapy Upon Intensive Care Medicine Department Admission Appears to Increase Mortality

F. Martins Pereira¹, S. Abreu², P. Mergulhão^3,4, J.A. Paiva^4,5,6
Abstract Number: PB0208

Discordance Between the Neutralization Profile of Apixaban, Betrixaban, Edoxaban and Rivaroxaban in the Clotting Assays and Anti-Xa Measurements

F. Siddiqui¹, A. Tafur², D. Hoppensteadt¹, E. Bontekoe¹, W. Jeske¹, B. Lewis¹, J. Fareed¹
Abstract Number: PB0835

Discrepancies between FVIII Assays in Routine Diagnosis and Treatment Monitoring of Haemophilia A

C. Fauconnier, M.-A. van Dievoet, C. Lambert, J.-P. Defour, S. Eeckhoudt, C. Hermans
Abstract Number: PB0570

Discrepant Interpretation of HIT Screening Results on the Same Sample – Data from a UK NEQAS for Blood Coagulation Exercise

I. Jennings, S. Kitchen, D. Kitchen, S. Munroe-Peart, A. Lowe, L. Brown, I. Walker
Abstract Number: PB0526

Discrimination between Acquired Hemophilia A and Lupus Anticoagulant Using Rotational Thromboelastometry (ROTEM)

Y. Chikasawa¹, K. Amano^1,2, R. Miyashita¹, T. Yamaguchi¹, Y. Kamikubo¹, A. Ichiki¹, M. Bingo¹, R. Sekiya¹, T. Muramatsu¹, M. Yotsumoto¹, M. Kaneko¹, K. Shinozawa², T. Hagiwara¹, H. Inaba¹, E. Kinai¹
Abstract Number: PB2547

Disorders in the Fibrinolytic System as a Possible Factor in the Failure of Assisted Reproductive Technologies

S. Safiullina^1,2, T. Vuimo³, Y. Kotova³, N. Ilizarova⁴
Abstract Number: PB1002

Dissecting the Paradox of “Severe” Hemophilia A (Clotting Factor VIII < 1%) with a Mild Clinical Phenotype in the Era of Prophylaxis

O.S. Bentur, B.S. Coller
Abstract Number: PB0644

Distinguishing Patients Presenting Prolonged Activated Partial Thromboplastin Time with and without Bleeding Diathesis by Comparison of Immediate and post Incubation Mixing Test

Y. Liu¹, W. Wu², X. Wang²
Abstract Number: PB1028

Distribution of Hemophilia A and B within the INSIGHT Consortium

A.-F. Zwagemaker¹, F.R. Kloosterman¹, J. Astermark², M. Carcao³, N. O'Connell⁴, G. Castaman⁵, S. Haya⁶, D.P. Hart⁷, C. Hermans⁸, S. Jackson⁹, R. Klamroth¹⁰, R. Lassila¹¹, R. Liesner¹², C. Male¹³, S. McRae¹⁴, K. Peerlinck¹⁵, H. Platokouki¹⁶, E. Santagostino¹⁷, C. Santoro¹⁸, K. Fijnvandraat^1,19
Abstract Number: PB0619

DOAC Intra-individual Variability in Patients with Non Valvular Atrial Fibrillation

O. Paoletti¹, C. Dellanoce¹, C. Legnani², V. Cancelli¹, R. Morandini¹, M. Tala¹, E. Cancellieri¹, S. Zambelli¹, M.C. Beati¹, M. Stramezzi¹, E. Spotti¹, V. Castellani¹, S. Lambiase¹, S. Testa¹
Abstract Number: PB1719

DOAC Pharmacogenomics: Personalized Therapeutics to Avoid Bleeding and Thrombotic Complications

C. Schekel¹, F. Shamoun², M. Abdelmalek², J. Wang², M. Girardo², Y. Kusne²
Abstract Number: PB0632

Doac-Remove Can Neutralize the Effect of Direct Oral Anticoagulants on Lupus Anticoagulant Assay: A Single-centre Experience

D. Velasco-Rodríguez, R. Vidal Laso, M. López Pérez, S. Martín Herrero, E. Jíménez Barral, A. García-Raso, R. de la Plaza, L.F. López Romero, D. Mínguez, M.Á. Bueno, P. Llamas Sillero
Abstract Number: PB2479

DOACs in Real Clinical Practice

M. Hulikova^1,2, J. Hulikova²
Abstract Number: PB2181

Does blood Group Predicts Thrombosis Risk? A Pilot Study Assessing Thrombin Generation

M. Marcos Jubilar¹, D. Terrasa², M.L. Palacios¹, V. Riego¹, L.E. Tamariz¹, R. Lecumberri¹, J.A. Páramo^1,3,4
Abstract Number: PB0551

Does Normal Diluted Russell Viper Venom Time Test Result Can Exclude Concentrations of Direct Oral Anticoagulants below 30 ng/mL?

S. Margetić¹, I. Ćelap², R. Mihić², S. Supraha Goreta³
Abstract Number: PB1910

Does the von Willebrand Factor: ADAMTS-13 Axis Differ between Antiphospholipid Syndrome and Systemic Lupus Erythematosus?

M.N. Dang¹, R. Thiagarajan¹, I. Mackie², H. Cohen^2,3, D. Isenberg^4,5, T. McKinnon¹, M. Efthymiou²
Abstract Number: PB0938

Does Variation between Label and Actual Potency of Factor VIII Concentrate Vials Affect Results of Pharmacokinetic (PK)-Guided Dosing of Replacement Therapy in Hemophilia A?

M.H.J. Goedhart¹, L.H. Bukkems², I. van Moort¹, C.C. Spence¹, S.C. Gouw³, R.A.A. Mathôt², M.H. Cnossen¹, for the OPTI-CLOT Study Group
Abstract Number: PB0751

Down-regulation of Plasminogen Activator Inhibitor-1 (PAI-1) by in vivo Thrombin Generation and Subsequent Formation of Activated Protein C (APC) in Carriers of the Factor V Leiden (FVL) and Prothrombin 20210G>A Mutation (PTM)

S. Reda, F.I. Winterhagen, C. Berens, J. Müller, J. Oldenburg, B. Pötzsch, H. Rühl
Abstract Number: PB0745

Downregulation of the Procarboxypeptidase U (proCPU, TAFI, proCPB2) System in ApoE^-/-Fbn1^C1039G+/- Mice Is a Non-Lipid Related Pleiotropic Effect of Statin Therapy

K. Claesen¹, K. Hermans¹, L. Roth², J.C. Mertens¹, I. De Meester¹, G.R.Y. De Meyer², D. Hendriks¹
Abstract Number: PB0651

DP-Filter, a Medical Device to Remove Edoxaban and Edoxaban-M4 from Plasma of Patients Taking Edoxaban

J. Favresse¹, C. Bouvy², R. Sirriez¹, P. Hainaut³, H. Yildiz³, A.-S. Delvigne², M. Hardy⁴, F. Mullier⁵, J.-M. Dogné¹, J. Douxfils^1,2
Abstract Number: PB0164

Drug Interactions in Edoxaban Treated Patients: A Pilot Study Revealing the Changes of the Metabolite to Parent Ratio and its Potential Clinical Importance

R. Siriez¹, J.-M. Dogné^1,2, J. Douxfils^1,3, M. Hardy^4,5, J. Laloy^2,6, F. Mullier⁴, H. Yildiz⁷, P. Hainaut⁷
Abstract Number: PB2459

Drug-Drug Interactions between Direct Oral Anticoagulants and Hepatitis C Direct-Acting Antiviral Agents: A Systematic Review

M. Bellesini^1,2, M. Bianchin³, C. Corradi⁴, M.P. Donadini^1,2, E. Raschi⁵, A. Squizzato^4,6
Abstract Number: PB1478

Dual Antiplatelet Therapy in One Patient with a Immune GPVI Deficiency

M. Jandrot-Perrus¹, S. Loyau¹, D. Faille^1,2, P. Gautier³, E. Gardiner⁴, P. Nurden⁵, N. Ajzenberg^1,2
Abstract Number: PB0933

Dynamic Changes in Peripheral Blood Transcriptome Profiles May Predict Inhibitor Formation in Previously Untreated Patients with Severe Hemophilia A

P. Batty^1,2, D. Watson¹, E. Wozniak¹, E. Savage¹, C.A. Mein¹, M.R. Barnes¹, D.P. Hart^1,2
Abstract Number: PB2260

Dynamic Upper Limb Ultrasound in Idiopathic Upper Extremity Deep Vein Thrombosis

H.L.A. Yuen^1,2, S. Chunilal^1,2
Abstract Number: PB2155

Dynamics of ADAMTS13 and vWF Activity Change in Ovarian Cancer Patients

A. Vorobev¹, V. Bitsadze¹, J. Khizroeva², A. Makatsariya², A. Solopova², M. Meng²
Abstract Number: PB1753

Dysfunctional CLEC-2- and GPVI-mediated Signaling in Syk Y342F Knock-in Mouse Platelets

J. Kostyak, B. Mauri, C. Dangelmaier, A. Patel, H. Reddy, S. Kunapuli
Abstract Number: PB1602

Dysfunctional RBM8A/Y14 Does Not Impair Megakaryopoiesis but Terminal Thrombopoiesis in Thrombocytopenia Absent Radii (TAR) Syndrome

G. Manukjan¹, C. Brähler¹, M. Becker¹, H. Bösing¹, C.K. Kwok², F. Edenhofer², C. Ghevaert³, D. French⁴, H. Schulze¹
Abstract Number: PB0461

Dyslipidaemia Associated with Increase of Thrombin Generation in Renal Transplant Recipients

S. Martins, L. Alves, M.D.G. Carvalho, L. Dusse, P. Alpoim, A.P. Mota
Abstract Number: PB1480

Dysregulation of Platelet Serotonin and Platelet 14-3-3-Related Biomarkers in Sudden Infant Death Syndrome

A.L. Frelinger III^1,2, R.L. Haynes^2,3, R.D. Goldstein^2,4, M.A. Berny-Lang¹, A.J. Gerrits¹, M. Riehs³, E.A. Haas⁵, B. Paunovic⁶, G.L. Milne⁷, L.A. Sleeper^2,8, H.C. Kinney^2,3, A.D. Michelson^1,2